Gene: ENSG00000213341 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000213341
Transcript Identifier
ENST00000370397
Gene Type
Coding gene
Location
10 : 100189598-100229532 : negative

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P074337
(2 genes in 2 species)
specific family

Descriptions

gene_descr
conserved helix-loop-helix ubiquitous kinase

Identifiers

Type Value
pidENSP00000359424
HGNC1974
UniprotO15111

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002011
IEA
Genome Projectmorphogenesis of an epithelial sheet
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0003009
IEA
Genome Projectskeletal muscle contraction
GO:0006468
IDA
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006954
TAS
Genome Projectinflammatory response
GO:0006955
TAS
Genome Projectimmune response
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007249
TAS
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007252
TAS
Genome ProjectI-kappaB phosphorylation
GO:0007266
IEA
Genome ProjectRho protein signal transduction
GO:0007595
IEA
Genome Projectlactation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0009615
TAS
Genome Projectresponse to virus
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0009653
TAS
Genome Projectanatomical structure morphogenesis
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010034
IEA
Genome Projectresponse to acetate
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030316
IEA
Genome Projectosteoclast differentiation
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0033194
IEA
Genome Projectresponse to hydroperoxide
GO:0033598
IEA
Genome Projectmammary gland epithelial cell proliferation
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0035994
IEA
Genome Projectresponse to muscle stretch
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043123
TAS, IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051146
IEA
Genome Projectstriated muscle cell differentiation
GO:0060749
IEA
Genome Projectmammary gland alveolus development
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008384
TAS, IEA
Genome ProjectIkappaB kinase activity
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0046982
IDA
IEA
Genome Projectprotein heterodimerization activity
GO:0097110
IDA
Genome Projectscaffold protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
TAS, IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0008385
TAS, IEA
Genome ProjectIkappaB kinase complex
GO:0009898
ISS
Genome Projectcytoplasmic side of plasma membrane
GO:0035631
ISS
Genome ProjectCD40 receptor complex
GO:0043231
IDA
IEA
Genome Projectintracellular membrane-bounded organelle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR022007I-kappa-kinase-beta NEMO binding domain

No MapMan annotations defined for this gene.