Gene: ENSG00000204217 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000204217
Transcript Identifier
ENST00000374580
Gene Type
Coding gene
Location
2 : 202377475-202559946 : positive

Family Information

Homologous gene family
HOM03P000002
(4173 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P073925
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
bone morphogenetic protein receptor, type II (serine/threonine kinase)

Identifiers

Type Value
pidENSP00000363708
HGNC1078
UniprotQ13873

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001707
ISS
IEA
Genome Projectmesoderm formation
GO:0001893
IEA
Genome Projectmaternal placenta development
GO:0001935
IMP
Genome Projectendothelial cell proliferation
GO:0001938
IMP
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001946
ISS
IEA
Genome Projectlymphangiogenesis
GO:0001974
ISS
IEA
Genome Projectblood vessel remodeling
GO:0002063
IMP
Genome Projectchondrocyte development
GO:0003085
IMP
Genome Projectnegative regulation of systemic arterial blood pressure
GO:0006366
IMP
Genome Projecttranscription from RNA polymerase II promoter
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007178
IDA
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420
IEA
Genome Projectbrain development
GO:0009267
IEP
Genome Projectcellular response to starvation
GO:0009952
ISS
IEA
Genome Projectanterior/posterior pattern specification
GO:0010595
IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0010634
IDA
Genome Projectpositive regulation of epithelial cell migration
GO:0010862
IMP
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916
IMP
ISS
Genome Projectregulation of lung blood pressure
GO:0016310
IEA
Genome Projectphosphorylation
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030166
ISS
Genome Projectproteoglycan biosynthetic process
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0030501
IMP
Genome Projectpositive regulation of bone mineralization
GO:0030509
IDA, IMP
ISS
TAS
Genome ProjectBMP signaling pathway
GO:0030513
IMP
Genome Projectpositive regulation of BMP signaling pathway
GO:0032924
TAS
Genome Projectactivin receptor signaling pathway
GO:0042127
IMP
Genome Projectregulation of cell proliferation
GO:0045669
IMP
Genome Projectpositive regulation of osteoblast differentiation
GO:0045906
ISS
IEA
Genome Projectnegative regulation of vasoconstriction
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048010
ISS
IEA
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048286
ISS
IEA
Genome Projectlung alveolus development
GO:0048842
IEA
Genome Projectpositive regulation of axon extension involved in axon guidance
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060173
IEA
Genome Projectlimb development
GO:0060350
ISS
Genome Projectendochondral bone morphogenesis
GO:0060836
ISS
IEA
Genome Projectlymphatic endothelial cell differentiation
GO:0060840
ISS
IEA
Genome Projectartery development
GO:0060841
ISS
IEA
Genome Projectvenous blood vessel development
GO:0061036
ISS
Genome Projectpositive regulation of cartilage development
GO:0061298
ISS
IEA
Genome Projectretina vasculature development in camera-type eye
GO:0071773
IMP
Genome Projectcellular response to BMP stimulus
GO:0072577
IMP
Genome Projectendothelial cell apoptotic process
GO:1902731
IMP
Genome Projectnegative regulation of chondrocyte proliferation
GO:2000279
IMP
Genome Projectnegative regulation of DNA biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004675
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase activity
GO:0004702
IEA
Genome Projectreceptor signaling protein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016362
TAS
Genome Projectactivin receptor activity, type II
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019838
IEA
Genome Projectgrowth factor binding
GO:0036122
IPI
Genome ProjectBMP binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
IDA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0005901
IMP
IEA
Genome Projectcaveola
GO:0009925
IEA
Genome Projectbasal plasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0030425
IEA
Genome Projectdendrite
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0044214
TAS
Genome Projectspanning component of plasma membrane
GO:0097481
IEA
Genome Projectneuronal postsynaptic density

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000333Ser/Thr protein kinase, TGFB receptor
IPR000472Activin types I and II receptor domain
IPR000719Protein kinase domain
IPR011009Protein kinase-like domain
IPR015770Bone morphogenetic protein receptor type-2
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.