Gene: ENSG00000198793 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000198793
Transcript Identifier
ENST00000361445
Gene Type
Coding gene
Location
1 : 11107485-11259409 : negative

Family Information

Homologous gene family
HOM03P000164
(189 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000559
(47 genes in 37 species)
specific family

Descriptions

gene_descr
mechanistic target of rapamycin (serine/threonine kinase)

Identifiers

Type Value
pidENSP00000354558
HGNC3942
UniprotP42345

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000724
IBA
Genome Projectdouble-strand break repair via homologous recombination
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0005979
IEA
Genome Projectregulation of glycogen biosynthetic process
GO:0006109
IEA
Genome Projectregulation of carbohydrate metabolic process
GO:0006207
IEA
Genome Project'de novo' pyrimidine nucleobase biosynthetic process
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006468
IDA, IMP
IEA
Genome Projectprotein phosphorylation
GO:0006950
IMP
Genome Projectresponse to stress
GO:0007050
TAS
Genome Projectcell cycle arrest
GO:0007165
NAS
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007281
IEA
Genome Projectgerm cell development
GO:0007584
NAS
Genome Projectresponse to nutrient
GO:0008286
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010467
TAS
Genome Projectgene expression
GO:0010507
ISS
IEA
Genome Projectnegative regulation of autophagy
GO:0010592
IEA
Genome Projectpositive regulation of lamellipodium assembly
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010831
IEA
Genome Projectpositive regulation of myotube differentiation
GO:0016049
IDA
TAS
Genome Projectcell growth
GO:0016242
IEA
Genome Projectnegative regulation of macroautophagy
GO:0016310
IDA
IEA
Genome Projectphosphorylation
GO:0018105
IMP
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
IEA
Genome Projectpeptidyl-threonine phosphorylation
GO:0030030
IEA
Genome Projectcell projection organization
GO:0030163
TAS
Genome Projectprotein catabolic process
GO:0030838
IEA
Genome Projectpositive regulation of actin filament polymerization
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0031529
IEA
Genome Projectruffle organization
GO:0031641
IEA
Genome Projectregulation of myelination
GO:0031669
ISS
IEA
Genome Projectcellular response to nutrient levels
GO:0031929
IMP
Genome ProjectTOR signaling
GO:0031998
IEA
Genome Projectregulation of fatty acid beta-oxidation
GO:0032095
IEA
Genome Projectregulation of response to food
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0032956
IMP
Genome Projectregulation of actin cytoskeleton organization
GO:0034605
TAS
Genome Projectcellular response to heat
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0040007
NAS
Genome Projectgrowth
GO:0043087
IEA
Genome Projectregulation of GTPase activity
GO:0043200
IDA
Genome Projectresponse to amino acid
GO:0043610
IEA
Genome Projectregulation of carbohydrate utilization
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045670
ISS
IEA
Genome Projectregulation of osteoclast differentiation
GO:0045727
IDA
IEA
Genome Projectpositive regulation of translation
GO:0045792
IEA
Genome Projectnegative regulation of cell size
GO:0045859
IEA
Genome Projectregulation of protein kinase activity
GO:0045945
IMP
Genome Projectpositive regulation of transcription from RNA polymerase III promoter
GO:0046777
IDA
IEA
Genome Projectprotein autophosphorylation
GO:0046889
IMP
Genome Projectpositive regulation of lipid biosynthetic process
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0050731
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051496
IEA
Genome Projectpositive regulation of stress fiber assembly
GO:0051534
IEA
Genome Projectnegative regulation of NFAT protein import into nucleus
GO:0051897
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0055006
IEA
Genome Projectcardiac cell development
GO:0071456
ISS
IEA
Genome Projectcellular response to hypoxia
GO:1900034
TAS
Genome Projectregulation of cellular response to heat
GO:1903147
NAS
Genome Projectnegative regulation of mitophagy

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001030
IDA
Genome ProjectRNA polymerase III type 1 promoter DNA binding
GO:0001031
IDA
Genome ProjectRNA polymerase III type 2 promoter DNA binding
GO:0001032
IDA
Genome ProjectRNA polymerase III type 3 promoter DNA binding
GO:0001156
IDA
Genome ProjectTFIIIC-class transcription factor binding
GO:0004674
EXP, IDA
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008144
IEA
Genome Projectdrug binding
GO:0016301
IDA
TAS, IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0016773
IEA
Genome Projectphosphotransferase activity, alcohol group as acceptor
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0043022
IEA
Genome Projectribosome binding
GO:0046983
IBA
Genome Projectprotein dimerization activity
GO:0051219
IPI
Genome Projectphosphoprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IEA
Genome ProjectGolgi membrane
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005741
IEA
Genome Projectmitochondrial outer membrane
GO:0005764
IDA
IEA
Genome Projectlysosome
GO:0005765
IDA
Genome Projectlysosomal membrane
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005942
NAS
Genome Projectphosphatidylinositol 3-kinase complex
GO:0012505
IDA
Genome Projectendomembrane system
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016605
ISS
IEA
Genome ProjectPML body
GO:0030425
IEA
Genome Projectdendrite
GO:0031931
IDA, IMP
IEA
Genome ProjectTORC1 complex
GO:0031932
IDA
Genome ProjectTORC2 complex
GO:0032991
IEA
Genome Projectmacromolecular complex
GO:0043025
IEA
Genome Projectneuronal cell body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151PIK-related kinase, FAT
IPR003152FATC domain
IPR009076Rapamycin-binding domain
IPR011009Protein kinase-like domain
IPR011989Armadillo-like helical
IPR011990Tetratricopeptide-like helical domain
IPR014009PIK-related kinase
IPR016024Armadillo-type fold
IPR018936Phosphatidylinositol 3/4-kinase, conserved site
IPR024585Domain of unknown function DUF3385, target of rapamycin protein
IPR026683Serine/threonine-protein kinase TOR

No MapMan annotations defined for this gene.