Gene: ENSG00000198626 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000198626
Transcript Identifier
ENST00000366574
Gene Type
Coding gene
Location
1 : 237042522-237832647 : positive

Family Information

Homologous gene family
HOM03P001263
(54 genes in 8 species)
specific family
Orthologous gene family
ORTHO03P012152
(7 genes in 4 species)
specific family

Descriptions

gene_descr
ryanodine receptor 2 (cardiac)

Identifiers

Type Value
pidENSP00000355533
HGNC10484
UniprotQ92736

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
ISS
IEA
Genome Projectresponse to hypoxia
GO:0002027
IMP
Genome Projectregulation of heart rate
GO:0003143
ISS
IEA
Genome Projectembryonic heart tube morphogenesis
GO:0003220
ISS
IEA
Genome Projectleft ventricular cardiac muscle tissue morphogenesis
GO:0003300
ISS
IEA
Genome Projectcardiac muscle hypertrophy
GO:0005513
IDA
Genome Projectdetection of calcium ion
GO:0006810
IEA
Genome Projecttransport
GO:0006811
IEA
Genome Projection transport
GO:0006816
IDA
IEA
Genome Projectcalcium ion transport
GO:0006874
ISS
IEA
Genome Projectcellular calcium ion homeostasis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0010460
ISS
IEA
Genome Projectpositive regulation of heart rate
GO:0010881
ISS
IC, IEA
Genome Projectregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882
IMP
Genome Projectregulation of cardiac muscle contraction by calcium ion signaling
GO:0014808
IMP
ISS
Genome Projectrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014850
IMP
Genome Projectresponse to muscle activity
GO:0019722
ISS
IEA
Genome Projectcalcium-mediated signaling
GO:0030509
IEA
Genome ProjectBMP signaling pathway
GO:0031000
IDA
Genome Projectresponse to caffeine
GO:0034220
TAS
Genome Projection transmembrane transport
GO:0035584
IDA
Genome Projectcalcium-mediated signaling using intracellular calcium source
GO:0035994
IMP
Genome Projectresponse to muscle stretch
GO:0051209
IDA
ISS
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051284
IDA
Genome Projectpositive regulation of sequestering of calcium ion
GO:0051480
ISS
Genome Projectcytosolic calcium ion homeostasis
GO:0051775
IDA
Genome Projectresponse to redox state
GO:0055085
TAS, IEA
Genome Projecttransmembrane transport
GO:0055117
IMP
Genome Projectregulation of cardiac muscle contraction
GO:0060048
IMP
Genome Projectcardiac muscle contraction
GO:0060070
IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060401
IEA
Genome Projectcytosolic calcium ion transport
GO:0060402
IDA
Genome Projectcalcium ion transport into cytosol
GO:0070296
TAS
Genome Projectsarcoplasmic reticulum calcium ion transport
GO:0070588
IEA
Genome Projectcalcium ion transmembrane transport
GO:0071313
IDA
ISS
Genome Projectcellular response to caffeine
GO:0071872
ISS
TAS, IEA
Genome Projectcellular response to epinephrine stimulus
GO:0072599
IDA
Genome Projectestablishment of protein localization to endoplasmic reticulum
GO:0086005
ISS
IEA
Genome Projectventricular cardiac muscle cell action potential
GO:0086029
ISS
IEA
Genome ProjectPurkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086064
IC
Genome Projectcell communication by electrical coupling involved in cardiac conduction
GO:0097050
IMP
Genome Projecttype B pancreatic cell apoptotic process
GO:0098735
IMP
Genome Projectpositive regulation of the force of heart contraction
GO:0098904
IMP
Genome Projectregulation of AV node cell action potential
GO:0098907
IMP
Genome Projectregulation of SA node cell action potential
GO:0098910
IMP
Genome Projectregulation of atrial cardiac muscle cell action potential
GO:0098911
IMP
Genome Projectregulation of ventricular cardiac muscle cell action potential
GO:1901896
IDA
Genome Projectpositive regulation of calcium-transporting ATPase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005216
IEA
Genome Projection channel activity
GO:0005218
ISS
IEA
Genome Projectintracellular ligand-gated calcium channel activity
GO:0005219
IDA
IEA
Genome Projectryanodine-sensitive calcium-release channel activity
GO:0005262
ISS
IEA
Genome Projectcalcium channel activity
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005516
IPI, IMP
ISS
IEA
Genome Projectcalmodulin binding
GO:0015278
IDA
Genome Projectcalcium-release channel activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0034236
IDA
Genome Projectprotein kinase A catalytic subunit binding
GO:0034237
IDA
Genome Projectprotein kinase A regulatory subunit binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0043621
IEA
Genome Projectprotein self-association
GO:0043924
IMP
Genome Projectsuramin binding
GO:0044325
ISS
Genome Projection channel binding
GO:0048763
IDA
Genome Projectcalcium-induced calcium release activity
GO:0097159
IEA
Genome Projectorganic cyclic compound binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005790
IEA
Genome Projectsmooth endoplasmic reticulum
GO:0005829
ISS
Genome Projectcytosol
GO:0005886
ISS
Genome Projectplasma membrane
GO:0014701
TAS
Genome Projectjunctional sarcoplasmic reticulum membrane
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016529
IDA
IEA
Genome Projectsarcoplasmic reticulum
GO:0030017
IEA
Genome Projectsarcomere
GO:0030018
ISS
IEA
Genome ProjectZ disc
GO:0033017
ISS
TAS, IEA
Genome Projectsarcoplasmic reticulum membrane
GO:0034704
IDA
Genome Projectcalcium channel complex
GO:0043234
IDA
Genome Projectprotein complex
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000699RIH (RyR and IP3R Homology) domain
IPR001870B30.2/SPRY domain
IPR002048EF-hand domain
IPR003032Ryanodine receptor Ryr
IPR003877SPRY domain
IPR005821Ion transport domain
IPR009460Ryanodine Receptor TM 4-6
IPR011992EF-hand domain pair
IPR013320Concanavalin A-like lectin/glucanase domain
IPR013333Ryanodine receptor
IPR013662RyR/IP3R Homology associated domain
IPR014821Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR015925Ryanodine receptor-related
IPR016093MIR motif

No MapMan annotations defined for this gene.