Gene: ENSG00000197122 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000197122
Transcript Identifier
ENST00000373558
Gene Type
Coding gene
Location
20 : 37384154-37403379 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P005517
(15 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
SRC proto-oncogene, non-receptor tyrosine kinase

Identifiers

Type Value
pidENSP00000362659
HGNC11283
UniprotP12931

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002376
IEA
Genome Projectimmune system process
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007049
IEA
Genome Projectcell cycle
GO:0007155
IBA
IEA
Genome Projectcell adhesion
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007172
TAS
Genome Projectsignal complex assembly
GO:0007173
IBA
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007179
IMP
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007229
IMP
Genome Projectintegrin-mediated signaling pathway
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007265
TAS
Genome ProjectRas protein signal transduction
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010632
IMP
Genome Projectregulation of epithelial cell migration
GO:0010634
IMP
Genome Projectpositive regulation of epithelial cell migration
GO:0016032
IEA
Genome Projectviral process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IEA
Genome Projectcell migration
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0022407
IMP
Genome Projectregulation of cell-cell adhesion
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030900
IEA
Genome Projectforebrain development
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0031648
IEA
Genome Projectprotein destabilization
GO:0032463
IMP
Genome Projectnegative regulation of protein homooligomerization
GO:0033146
IEA
Genome Projectregulation of intracellular estrogen receptor signaling pathway
GO:0033625
TAS
Genome Projectpositive regulation of integrin activation
GO:0034446
IEA
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0034614
IEA
Genome Projectcellular response to reactive oxygen species
GO:0035556
IDA
TAS
Genome Projectintracellular signal transduction
GO:0036035
IBA
IEA
Genome Projectosteoclast development
GO:0036120
IEA
Genome Projectcellular response to platelet-derived growth factor stimulus
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043114
TAS
Genome Projectregulation of vascular permeability
GO:0043149
IMP
Genome Projectstress fiber assembly
GO:0043154
IMP
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393
IEA
Genome Projectregulation of protein binding
GO:0045087
IBA
TAS
Genome Projectinnate immune response
GO:0045124
TAS
Genome Projectregulation of bone resorption
GO:0045453
ISS, IBA
IEA
Genome Projectbone resorption
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0048477
IEA
Genome Projectoogenesis
GO:0050731
IC
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050847
ISS, IBA
Genome Projectprogesterone receptor signaling pathway
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0051726
IBA
Genome Projectregulation of cell cycle
GO:0051895
ISS
Genome Projectnegative regulation of focal adhesion assembly
GO:0051897
IMP
Genome Projectpositive regulation of protein kinase B signaling
GO:0051902
IMP
Genome Projectnegative regulation of mitochondrial depolarization
GO:0060065
IEA
Genome Projectuterus development
GO:0060444
IEA
Genome Projectbranching involved in mammary gland duct morphogenesis
GO:0060491
IEA
Genome Projectregulation of cell projection assembly
GO:0061024
TAS
Genome Projectmembrane organization
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070555
IMP
Genome Projectresponse to interleukin-1
GO:0071375
ISS, IBA
Genome Projectcellular response to peptide hormone stimulus
GO:0071393
ISS
Genome Projectcellular response to progesterone stimulus
GO:0071498
IEA
Genome Projectcellular response to fluid shear stress
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0071801
IBA
Genome Projectregulation of podosome assembly
GO:0071803
IEA
Genome Projectpositive regulation of podosome assembly
GO:0086098
ISS
IEA
Genome Projectangiotensin-activated signaling pathway involved in heart process
GO:0090263
IEA
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:2000394
IMP
Genome Projectpositive regulation of lamellipodium morphogenesis
GO:2000641
IMP
Genome Projectregulation of early endosome to late endosome transport
GO:2000811
IMP
Genome Projectnegative regulation of anoikis
GO:2001237
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001243
IMP
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway
GO:2001286
IMP
Genome Projectregulation of caveolin-mediated endocytosis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
TAS, IEA
Genome Projectprotein kinase activity
GO:0004713
EXP, IDA
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
TAS, IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005070
TAS
Genome ProjectSH3/SH2 adaptor activity
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005178
TAS
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
TAS, IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0020037
IDA
Genome Projectheme binding
GO:0042169
IPI
Genome ProjectSH2 domain binding
GO:0044325
IPI
Genome Projection channel binding
GO:0046875
IPI
Genome Projectephrin receptor binding
GO:0051219
IPI
Genome Projectphosphoprotein binding
GO:0051427
IBA
Genome Projecthormone receptor binding
GO:0070851
IPI
Genome Projectgrowth factor receptor binding
GO:0097110
IPI
Genome Projectscaffold protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005743
IDA
IEA
Genome Projectmitochondrial inner membrane
GO:0005764
IDA
Genome Projectlysosome
GO:0005770
IDA
Genome Projectlate endosome
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005884
IEA
Genome Projectactin filament
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005901
IDA
Genome Projectcaveola
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0032587
IEA
Genome Projectruffle membrane
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.