Gene: ENSG00000196961 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000196961
Transcript Identifier
ENST00000359032
Gene Type
Coding gene
Location
19 : 49767134-49806758 : positive

Family Information

Homologous gene family
HOM03P000218
(163 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000829
(43 genes in 34 species)
specific family

Descriptions

gene_descr
adaptor-related protein complex 2, alpha 1 subunit

Identifiers

Type Value
pidENSP00000351926
HGNC561
UniprotO95782

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006810
IEA
Genome Projecttransport
GO:0006886
NAS, IEA
Genome Projectintracellular protein transport
GO:0006895
NAS
Genome ProjectGolgi to endosome transport
GO:0006897
NAS, IEA
Genome Projectendocytosis
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007268
TAS
Genome Projectsynaptic transmission
GO:0007411
TAS
Genome Projectaxon guidance
GO:0015031
IEA
Genome Projectprotein transport
GO:0016032
TAS
Genome Projectviral process
GO:0016192
IEA
Genome Projectvesicle-mediated transport
GO:0019886
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059
TAS
Genome Projectnegative regulation of epidermal growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0050690
TAS
Genome Projectregulation of defense response to virus by virus
GO:0072583
TAS
Genome Projectclathrin-mediated endocytosis
GO:1900126
IDA, IMP
Genome Projectnegative regulation of hyaluronan biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0008022
IEA
Genome Projectprotein C-terminus binding
GO:0008565
IEA
Genome Projectprotein transporter activity
GO:0019901
ISS
IEA
Genome Projectprotein kinase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0035615
TAS
Genome Projectclathrin adaptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005905
IEA
Genome Projectcoated pit
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016323
IEA
Genome Projectbasolateral plasma membrane
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0030117
IEA
Genome Projectmembrane coat
GO:0030122
TAS, NAS
Genome ProjectAP-2 adaptor complex
GO:0030130
NAS
Genome Projectclathrin coat of trans-Golgi network vesicle
GO:0030131
IEA
Genome Projectclathrin adaptor complex
GO:0030666
TAS
Genome Projectendocytic vesicle membrane
GO:0030669
TAS
Genome Projectclathrin-coated endocytic vesicle membrane
GO:0032433
IEA
Genome Projectfilopodium tip
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002553Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR003164Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
IPR008152Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR009028Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR011989Armadillo-like helical
IPR013038Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain
IPR013041Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR015873Clathrin alpha-adaptin/coatomer adaptor, appendage, C-terminal subdomain
IPR016024Armadillo-type fold
IPR017104Adaptor protein complex AP-2, alpha subunit

No MapMan annotations defined for this gene.