Gene: ENSG00000188906 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000188906
Transcript Identifier
ENST00000298910
Gene Type
Coding gene
Location
12 : 40225132-40367765 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P064884
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
leucine-rich repeat kinase 2

Identifiers

Type Value
pidENSP00000298910
HGNC18618
UniprotQ5S007

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IDA
Genome ProjectMAPK cascade
GO:0000186
IDA
Genome Projectactivation of MAPKK activity
GO:0000187
IMP
Genome Projectactivation of MAPK activity
GO:0001933
ISS
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0006468
IMP
IEA
Genome Projectprotein phosphorylation
GO:0006897
IMP, IGI
Genome Projectendocytosis
GO:0006914
IEA
Genome Projectautophagy
GO:0006979
IMP
Genome Projectresponse to oxidative stress
GO:0007005
IMP
Genome Projectmitochondrion organization
GO:0007030
IEA
Genome ProjectGolgi organization
GO:0007040
IMP
Genome Projectlysosome organization
GO:0007264
IEA
Genome Projectsmall GTPase mediated signal transduction
GO:0007528
IMP
Genome Projectneuromuscular junction development
GO:0008340
IMP
Genome Projectdetermination of adult lifespan
GO:0010508
IMP
ISS
Genome Projectpositive regulation of autophagy
GO:0010738
ISS
IEA
Genome Projectregulation of protein kinase A signaling
GO:0010955
IDA
Genome Projectnegative regulation of protein processing
GO:0014041
IMP
Genome Projectregulation of neuron maturation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
IDA, IMP
Genome Projectpeptidyl-threonine phosphorylation
GO:0019722
IMP
Genome Projectcalcium-mediated signaling
GO:0021772
IMP
Genome Projectolfactory bulb development
GO:0022028
IMP
Genome Projecttangential migration from the subventricular zone to the olfactory bulb
GO:0030154
IEA
Genome Projectcell differentiation
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0032091
IMP
Genome Projectnegative regulation of protein binding
GO:0032092
IDA
Genome Projectpositive regulation of protein binding
GO:0032436
ISS
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034260
IDA
Genome Projectnegative regulation of GTPase activity
GO:0034599
IMP
Genome Projectcellular response to oxidative stress
GO:0034613
ISS
IEA
Genome Projectcellular protein localization
GO:0035556
ISS
IEA
Genome Projectintracellular signal transduction
GO:0035564
ISS
IEA
Genome Projectregulation of kidney size
GO:0035640
IMP
Genome Projectexploration behavior
GO:0035641
IEA
Genome Projectlocomotory exploration behavior
GO:0040012
IMP
Genome Projectregulation of locomotion
GO:0042391
IMP
Genome Projectregulation of membrane potential
GO:0043068
IDA
Genome Projectpositive regulation of programmed cell death
GO:0043406
IC
Genome Projectpositive regulation of MAP kinase activity
GO:0043547
IDA
IEA
Genome Projectpositive regulation of GTPase activity
GO:0046039
IDA
Genome ProjectGTP metabolic process
GO:0046777
IDA, IMP
Genome Projectprotein autophosphorylation
GO:0048312
IMP
Genome Projectintracellular distribution of mitochondria
GO:0048812
IMP
Genome Projectneuron projection morphogenesis
GO:0051646
IMP
Genome Projectmitochondrion localization
GO:0051900
IMP
Genome Projectregulation of mitochondrial depolarization
GO:0051966
ISS
IEA
Genome Projectregulation of synaptic transmission, glutamatergic
GO:0060079
ISS
IEA
Genome Projectexcitatory postsynaptic potential
GO:0060159
ISS
IEA
Genome Projectregulation of dopamine receptor signaling pathway
GO:0060161
IMP
Genome Projectpositive regulation of dopamine receptor signaling pathway
GO:0061001
IMP
ISS
Genome Projectregulation of dendritic spine morphogenesis
GO:0070585
TAS
Genome Projectprotein localization to mitochondrion
GO:0070997
IMP
Genome Projectneuron death
GO:0071287
IMP
Genome Projectcellular response to manganese ion
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0072593
IMP
Genome Projectreactive oxygen species metabolic process
GO:0090140
TAS
Genome Projectregulation of mitochondrial fission
GO:0090394
ISS
Genome Projectnegative regulation of excitatory postsynaptic potential
GO:1901214
IMP
Genome Projectregulation of neuron death
GO:1901215
IGI
Genome Projectnegative regulation of neuron death
GO:1902236
IMP
Genome Projectnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902499
IDA
Genome Projectpositive regulation of protein autoubiquitination
GO:1902692
IMP
Genome Projectregulation of neuroblast proliferation
GO:1902803
ISS
TAS, IEA
Genome Projectregulation of synaptic vesicle transport
GO:1902823
TAS
Genome Projectnegative regulation of late endosome to lysosome transport
GO:1903125
IDA
Genome Projectnegative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903206
IMP
Genome Projectnegative regulation of hydrogen peroxide-induced cell death
GO:1903215
IDA
Genome Projectnegative regulation of protein targeting to mitochondrion
GO:1903217
IC
Genome Projectnegative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903351
IMP
Genome Projectcellular response to dopamine
GO:2000172
IMP
Genome Projectregulation of branching morphogenesis of a nerve
GO:2000300
IMP
Genome Projectregulation of synaptic vesicle exocytosis
GO:2000469
IDA
Genome Projectnegative regulation of peroxidase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000149
IPI
Genome ProjectSNARE binding
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001948
IPI
Genome Projectglycoprotein binding
GO:0003779
IPI
Genome Projectactin binding
GO:0003924
IDA
Genome ProjectGTPase activity
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004708
IDA
Genome ProjectMAP kinase kinase activity
GO:0005096
IDA
IEA
Genome ProjectGTPase activator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0005525
IDA
IEA
Genome ProjectGTP binding
GO:0015631
IDA
Genome Projecttubulin binding
GO:0016301
IDA
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0017048
IPI
Genome ProjectRho GTPase binding
GO:0017075
IPI
Genome Projectsyntaxin-1 binding
GO:0030276
IPI
Genome Projectclathrin binding
GO:0034211
IDA, IMP
Genome ProjectGTP-dependent protein kinase activity
GO:0036479
IDA
Genome Projectperoxidase inhibitor activity
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0044325
IPI
Genome Projection channel binding
GO:0051018
IPI
Genome Projectprotein kinase A binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
IDA
Genome Projectextracellular space
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005741
ISS
IEA
Genome Projectmitochondrial outer membrane
GO:0005743
ISS
IEA
Genome Projectmitochondrial inner membrane
GO:0005759
ISS
IEA
Genome Projectmitochondrial matrix
GO:0005764
ISS
IEA
Genome Projectlysosome
GO:0005768
ISS
IEA
Genome Projectendosome
GO:0005783
ISS
IEA
Genome Projectendoplasmic reticulum
GO:0005794
ISS
IEA
Genome ProjectGolgi apparatus
GO:0005802
IEA
Genome Projecttrans-Golgi network
GO:0005829
IDA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0008021
IEA
Genome Projectsynaptic vesicle
GO:0016020
IEA
Genome Projectmembrane
GO:0016234
IMP
Genome Projectinclusion body
GO:0030054
IEA
Genome Projectcell junction
GO:0030424
IDA
ISS
IEA
Genome Projectaxon
GO:0030425
IDA
ISS
IEA
Genome Projectdendrite
GO:0030529
IEA
Genome Projectintracellular ribonucleoprotein complex
GO:0030672
IEA
Genome Projectsynaptic vesicle membrane
GO:0031410
ISS
IEA
Genome Projectcytoplasmic vesicle
GO:0031966
IDA
Genome Projectmitochondrial membrane
GO:0032473
IDA
Genome Projectcytoplasmic side of mitochondrial outer membrane
GO:0032839
IDA
Genome Projectdendrite cytoplasm
GO:0042995
IEA
Genome Projectcell projection
GO:0043005
IDA
IEA
Genome Projectneuron projection
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043195
TAS
Genome Projectterminal bouton
GO:0043204
IDA
ISS
IEA
Genome Projectperikaryon
GO:0043231
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0045121
IEA
Genome Projectmembrane raft
GO:0045202
IEA
Genome Projectsynapse
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001611Leucine-rich repeat
IPR001680WD40 repeat
IPR003591Leucine-rich repeat, typical subtype
IPR005225Small GTP-binding protein domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011989Armadillo-like helical
IPR013684Mitochondrial Rho-like
IPR015943WD40/YVTN repeat-like-containing domain
IPR016024Armadillo-type fold
IPR017441Protein kinase, ATP binding site
IPR017986WD40-repeat-containing domain
IPR020683Ankyrin repeat-containing domain
IPR020859Roc domain
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR032171C-terminal of Roc (COR) domain

No MapMan annotations defined for this gene.