Gene: ENSG00000188157 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000188157
Transcript Identifier
ENST00000379370
Gene Type
Coding gene
Location
1 : 1020173-1054981 : positive

Family Information

Homologous gene family
HOM03P006322
(14 genes in 4 species)
specific family

Descriptions

gene_descr
agrin

Identifiers

Type Value
pidENSP00000368678
HGNC329
UniprotO00468

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001523
TAS
Genome Projectretinoid metabolic process
GO:0005975
TAS
Genome Projectcarbohydrate metabolic process
GO:0006024
TAS
Genome Projectglycosaminoglycan biosynthetic process
GO:0006027
TAS
Genome Projectglycosaminoglycan catabolic process
GO:0007009
IEA
Genome Projectplasma membrane organization
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007213
TAS, IEA
Genome ProjectG-protein coupled acetylcholine receptor signaling pathway
GO:0007268
IEA
Genome Projectsynaptic transmission
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007528
IEA
Genome Projectneuromuscular junction development
GO:0007603
TAS
Genome Projectphototransduction, visible light
GO:0008582
IEA
Genome Projectregulation of synaptic growth at neuromuscular junction
GO:0010469
IEA
Genome Projectregulation of receptor activity
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030203
TAS
Genome Projectglycosaminoglycan metabolic process
GO:0030204
TAS
Genome Projectchondroitin sulfate metabolic process
GO:0043113
IDA, IMP
IEA
Genome Projectreceptor clustering
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0043547
ISS
Genome Projectpositive regulation of GTPase activity
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045162
TAS
Genome Projectclustering of voltage-gated sodium channels
GO:0045213
IEA
Genome Projectneurotransmitter receptor metabolic process
GO:0045887
ISS
Genome Projectpositive regulation of synaptic growth at neuromuscular junction
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050808
TAS
Genome Projectsynapse organization
GO:0051491
ISS
Genome Projectpositive regulation of filopodium assembly

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002162
ISS
Genome Projectdystroglycan binding
GO:0005200
TAS
Genome Projectstructural constituent of cytoskeleton
GO:0005509
ISS
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0030548
IEA
Genome Projectacetylcholine receptor regulator activity
GO:0033691
ISS
Genome Projectsialic acid binding
GO:0035374
ISS
Genome Projectchondroitin sulfate binding
GO:0043236
TAS, IEA
Genome Projectlaminin binding
GO:0043395
ISS
Genome Projectheparan sulfate proteoglycan binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005604
IEA
Genome Projectbasement membrane
GO:0005605
IDA
Genome Projectbasal lamina
GO:0005615
IEA
Genome Projectextracellular space
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005796
TAS
Genome ProjectGolgi lumen
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030054
IEA
Genome Projectcell junction
GO:0031012
IDA
TAS
Genome Projectextracellular matrix
GO:0043202
TAS
Genome Projectlysosomal lumen
GO:0045202
ISS
IEA
Genome Projectsynapse
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000082SEA domain
IPR000742EGF-like domain
IPR001791Laminin G domain
IPR002049Laminin EGF domain
IPR002350Kazal domain
IPR003645Follistatin-like, N-terminal
IPR004850NtA (N-terminal agrin) domain
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR013032EGF-like, conserved site
IPR013320Concanavalin A-like lectin/glucanase domain

No MapMan annotations defined for this gene.