Gene: ENSG00000186951 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000186951
Transcript Identifier
ENST00000402126
Gene Type
Coding gene
Location
22 : 46198384-46235380 : positive

Family Information

Homologous gene family
HOM03P000128
(228 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P017214
(5 genes in 3 species)
specific family

Descriptions

gene_descr
peroxisome proliferator-activated receptor alpha

Identifiers

Type Value
pidENSP00000385246
HGNC9232
UniprotQ07869
UniprotF1D8S4

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006631
TAS, IEA
Genome Projectfatty acid metabolic process
GO:0007507
IEA
Genome Projectheart development
GO:0008544
IEA
Genome Projectepidermis development
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0019217
IEA
Genome Projectregulation of fatty acid metabolic process
GO:0030522
IDA
IEA
Genome Projectintracellular receptor signaling pathway
GO:0032091
IEA
Genome Projectnegative regulation of protein binding
GO:0032099
ISS
IEA
Genome Projectnegative regulation of appetite
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0032922
ISS
IEA
Genome Projectcircadian regulation of gene expression
GO:0035095
IEA
Genome Projectbehavioral response to nicotine
GO:0042060
IEA
Genome Projectwound healing
GO:0042157
IEA
Genome Projectlipoprotein metabolic process
GO:0042752
ISS
IEA
Genome Projectregulation of circadian rhythm
GO:0043401
IEA
Genome Projectsteroid hormone mediated signaling pathway
GO:0045722
IEA
Genome Projectpositive regulation of gluconeogenesis
GO:0045776
IEA
Genome Projectnegative regulation of blood pressure
GO:0045944
IDA
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046321
ISS
IEA
Genome Projectpositive regulation of fatty acid oxidation
GO:0070166
IEA
Genome Projectenamel mineralization
GO:1901215
IEA
Genome Projectnegative regulation of neuron death
GO:2000678
IEA
Genome Projectnegative regulation of transcription regulatory region DNA binding
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006629
TAS
Genome Projectlipid metabolic process
GO:0007623
TAS
Genome Projectcircadian rhythm
GO:0010467
TAS
Genome Projectgene expression
GO:0010745
IDA
IC
Genome Projectnegative regulation of macrophage derived foam cell differentiation
GO:0010871
IDA
Genome Projectnegative regulation of receptor biosynthetic process
GO:0010887
IDA
Genome Projectnegative regulation of cholesterol storage
GO:0010891
IDA
Genome Projectnegative regulation of sequestering of triglyceride
GO:0015908
TAS
Genome Projectfatty acid transport
GO:0032000
TAS
Genome Projectpositive regulation of fatty acid beta-oxidation
GO:0044255
TAS
Genome Projectcellular lipid metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045820
IC
Genome Projectnegative regulation of glycolytic process
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048511
IEA
Genome Projectrhythmic process
GO:0072363
IDA
Genome Projectregulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072366
IDA
Genome Projectregulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369
IDA
Genome Projectregulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001190
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677
TAS, IEA
Genome ProjectDNA binding
GO:0003700
IDA
ISS
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003707
IDA
IEA
Genome Projectsteroid hormone receptor activity
GO:0004872
IEA
Genome Projectreceptor activity
GO:0004879
IDA
IEA
Genome ProjectRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0019902
IEA
Genome Projectphosphatase binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0043565
ISS
IEA
Genome Projectsequence-specific DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051525
IEA
Genome ProjectNFAT protein binding
GO:0097371
IEA
Genome ProjectMDM2/MDM4 family protein binding
GO:0000978
IDA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078
IDA
Genome Projecttranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001103
IPI
Genome ProjectRNA polymerase II repressing transcription factor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008144
IDA
Genome Projectdrug binding
GO:0008289
IDA
IEA
Genome Projectlipid binding
GO:0031624
IPI
Genome Projectubiquitin conjugating enzyme binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
TAS, IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000536Nuclear hormone receptor, ligand-binding domain
IPR001628Zinc finger, nuclear hormone receptor-type
IPR001723Nuclear hormone receptor
IPR003074Peroxisome proliferator-activated receptor
IPR003076Peroxisome proliferator-activated receptor, alpha
IPR013088Zinc finger, NHR/GATA-type

No MapMan annotations defined for this gene.