Gene: ENSG00000186716 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000186716
Transcript Identifier
ENST00000305877
Gene Type
Coding gene
Location
22 : 23180961-23315522 : positive

Family Information

Homologous gene family
HOM03P000257
(144 genes in 11 species)
specific family
Orthologous gene family
ORTHO03P012124
(7 genes in 3 species)
specific family

Descriptions

gene_descr
breakpoint cluster region

Identifiers

Type Value
pidENSP00000303507
HGNC1014
UniprotP11274

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002692
IEA
Genome Projectnegative regulation of cellular extravasation
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007420
IEA
Genome Projectbrain development
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
TAS
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030036
IEA
Genome Projectactin cytoskeleton organization
GO:0030336
IEA
Genome Projectnegative regulation of cell migration
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0035023
IEA
Genome Projectregulation of Rho protein signal transduction
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0042472
IEA
Genome Projectinner ear morphogenesis
GO:0043114
IEA
Genome Projectregulation of vascular permeability
GO:0043314
IEA
Genome Projectnegative regulation of neutrophil degranulation
GO:0043547
TAS, IEA
Genome Projectpositive regulation of GTPase activity
GO:0046777
IEA
Genome Projectprotein autophosphorylation
GO:0048008
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0050728
IEA
Genome Projectnegative regulation of inflammatory response
GO:0050766
IEA
Genome Projectpositive regulation of phagocytosis
GO:0050885
IEA
Genome Projectneuromuscular process controlling balance
GO:0051056
TAS
Genome Projectregulation of small GTPase mediated signal transduction
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0060313
IEA
Genome Projectnegative regulation of blood vessel remodeling

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004674
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004713
TAS
Genome Projectprotein tyrosine kinase activity
GO:0005085
IEA
Genome Projectguanyl-nucleotide exchange factor activity
GO:0005089
IEA
Genome ProjectRho guanyl-nucleotide exchange factor activity
GO:0005096
TAS, IEA
Genome ProjectGTPase activator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
TAS, IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019899
IEA
Genome Projectenzyme binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0014069
ISS
IEA
Genome Projectpostsynaptic density
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0030054
IEA
Genome Projectcell junction
GO:0043234
IDA
Genome Projectprotein complex
GO:0045202
IEA
Genome Projectsynapse
GO:0045211
IEA
Genome Projectpostsynaptic membrane
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000008C2 domain
IPR000198Rho GTPase-activating protein domain
IPR000219Dbl homology (DH) domain
IPR001331Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001849Pleckstrin homology domain
IPR008936Rho GTPase activation protein
IPR011993PH domain-like
IPR015123Bcr-Abl oncoprotein oligomerisation

No MapMan annotations defined for this gene.