Gene: ENSG00000186575 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000186575
Transcript Identifier
ENST00000338641
Gene Type
Coding gene
Location
22 : 29603999-29694802 : positive

Family Information

Homologous gene family
HOM03P007566
(11 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P066018
(2 genes in 2 species)
specific family

Descriptions

gene_descr
neurofibromin 2 (merlin)

Identifiers

Type Value
pidENSP00000344666
HGNC7773
UniprotP35240
UniprotA0A024R1J8

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001707
IEA
Genome Projectmesoderm formation
GO:0006469
IEA
Genome Projectnegative regulation of protein kinase activity
GO:0007398
IEA
Genome Projectectoderm development
GO:0007420
IEA
Genome Projectbrain development
GO:0021766
IEA
Genome Projecthippocampus development
GO:0030308
IEA
Genome Projectnegative regulation of cell growth
GO:0031647
IEA
Genome Projectregulation of protein stability
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0043409
IEA
Genome Projectnegative regulation of MAPK cascade
GO:0045216
IEA
Genome Projectcell-cell junction organization
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0070306
IEA
Genome Projectlens fiber cell differentiation
GO:1900180
IEA
Genome Projectregulation of protein localization to nucleus
GO:2000177
IEA
Genome Projectregulation of neural precursor cell proliferation
GO:0001953
TAS
Genome Projectnegative regulation of cell-matrix adhesion
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0008156
IMP
Genome Projectnegative regulation of DNA replication
GO:0008285
IDA, IMP
Genome Projectnegative regulation of cell proliferation
GO:0014010
IMP
Genome ProjectSchwann cell proliferation
GO:0022408
IDA
Genome Projectnegative regulation of cell-cell adhesion
GO:0030036
IMP
Genome Projectactin cytoskeleton organization
GO:0030336
TAS
Genome Projectnegative regulation of cell migration
GO:0035330
IMP
Genome Projectregulation of hippo signaling
GO:0042518
IDA
Genome Projectnegative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524
IDA
Genome Projectnegative regulation of tyrosine phosphorylation of Stat5 protein
GO:0046426
IDA
Genome Projectnegative regulation of JAK-STAT cascade
GO:0051496
IMP
Genome Projectpositive regulation of stress fiber assembly

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003779
IEA
Genome Projectactin binding
GO:0005178
IEA
Genome Projectintegrin binding
GO:0008013
IEA
Genome Projectbeta-catenin binding
GO:0008092
IEA
Genome Projectcytoskeletal protein binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001726
IEA
Genome Projectruffle
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005856
TAS, IEA
Genome Projectcytoskeleton
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005912
IEA
Genome Projectadherens junction
GO:0019898
IEA
Genome Projectextrinsic component of membrane
GO:0030027
IEA
Genome Projectlamellipodium
GO:0030175
IEA
Genome Projectfilopodium
GO:0030864
IEA
Genome Projectcortical actin cytoskeleton
GO:0032154
IEA
Genome Projectcleavage furrow
GO:0043234
IEA
Genome Projectprotein complex
GO:0045121
IEA
Genome Projectmembrane raft
GO:0045177
IEA
Genome Projectapical part of cell
GO:0045202
IEA
Genome Projectsynapse
GO:0048471
IDA
IEA
Genome Projectperinuclear region of cytoplasm
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005730
IDA
Genome Projectnucleolus
GO:0005769
IDA
Genome Projectearly endosome
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0031527
IEA
Genome Projectfilopodium membrane
GO:0032587
IEA
Genome Projectruffle membrane
GO:0042995
IEA
Genome Projectcell projection

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000299FERM domain
IPR000798Ezrin/radixin/moesin-like
IPR008954Moesin tail domain
IPR011174Ezrin/radixin/moesin
IPR011259Ezrin/radixin/moesin, C-terminal
IPR011993PH domain-like
IPR014352FERM/acyl-CoA-binding protein, 3-helical bundle
IPR018979FERM, N-terminal
IPR018980FERM, C-terminal PH-like domain
IPR019747FERM conserved site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.