Gene: ENSG00000186297 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000186297
Transcript Identifier
ENST00000400081
Gene Type
Coding gene
Location
15 : 26869249-26948233 : positive

Family Information

Homologous gene family
HOM03P000436
(104 genes in 8 species)
specific family
Orthologous gene family
ORTHO03P011584
(7 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
gamma-aminobutyric acid (GABA) A receptor, alpha 5

Identifiers

Type Value
pidENSP00000382953
HGNC4079
UniprotP31644

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001662
IEA
Genome Projectbehavioral fear response
GO:0002230
IMP
Genome Projectpositive regulation of defense response to virus by host
GO:0006810
TAS, IEA
Genome Projecttransport
GO:0006811
IEA
Genome Projection transport
GO:0006821
IEA
Genome Projectchloride transport
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007214
IBA
IEA
Genome Projectgamma-aminobutyric acid signaling pathway
GO:0007268
IBA
TAS, IEA
Genome Projectsynaptic transmission
GO:0007420
IEA
Genome Projectbrain development
GO:0007605
IEA
Genome Projectsensory perception of sound
GO:0008306
IEA
Genome Projectassociative learning
GO:0034220
TAS
Genome Projection transmembrane transport
GO:0042391
IBA
Genome Projectregulation of membrane potential
GO:0042493
IBA
Genome Projectresponse to drug
GO:0043523
IEA
Genome Projectregulation of neuron apoptotic process
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0048666
IEA
Genome Projectneuron development
GO:0050877
IBA
Genome Projectneurological system process
GO:0055085
TAS
Genome Projecttransmembrane transport
GO:0060119
IEA
Genome Projectinner ear receptor cell development
GO:0060384
IEA
Genome Projectinnervation
GO:0090102
IEA
Genome Projectcochlea development
GO:0098779
IGI
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1902476
IBA
Genome Projectchloride transmembrane transport

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004872
TAS
Genome Projectreceptor activity
GO:0004890
IBA
IEA
Genome ProjectGABA-A receptor activity
GO:0005215
TAS
Genome Projecttransporter activity
GO:0005216
IEA
Genome Projection channel activity
GO:0005230
IEA
Genome Projectextracellular ligand-gated ion channel activity
GO:0005237
IBA
Genome Projectinhibitory extracellular ligand-gated ion channel activity
GO:0005254
IBA
IEA
Genome Projectchloride channel activity
GO:0050811
IEA
Genome ProjectGABA receptor binding
GO:0008503
IBA
Genome Projectbenzodiazepine receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030054
IEA
Genome Projectcell junction
GO:0030425
IEA
Genome Projectdendrite
GO:0032809
IEA
Genome Projectneuronal cell body membrane
GO:0034707
IEA
Genome Projectchloride channel complex
GO:0043005
IBA
Genome Projectneuron projection
GO:0043235
IEA
Genome Projectreceptor complex
GO:0044297
IEA
Genome Projectcell body
GO:0045202
IBA
IEA
Genome Projectsynapse
GO:0045211
IEA
Genome Projectpostsynaptic membrane
GO:1902711
IBA
Genome ProjectGABA-A receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001390Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005435Gamma-aminobutyric-acid A receptor, alpha 5 subunit
IPR006028Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029Neurotransmitter-gated ion-channel transmembrane domain
IPR006201Neurotransmitter-gated ion-channel
IPR006202Neurotransmitter-gated ion-channel ligand-binding domain
IPR018000Neurotransmitter-gated ion-channel, conserved site

No MapMan annotations defined for this gene.