Gene: ENSG00000185920 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000185920
Transcript Identifier
ENST00000331920
Gene Type
Coding gene
Location
9 : 95446912-95508361 : negative

Family Information

Homologous gene family
HOM03P000381
(116 genes in 33 species)
specific family
Orthologous gene family
ORTHO03P010307
(8 genes in 4 species)
specific family

Descriptions

gene_descr
patched 1

Identifiers

Type Value
pidENSP00000332353
HGNC9585
UniprotQ13635

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001658
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001709
IEA
Genome Projectcell fate determination
GO:0001841
IEA
Genome Projectneural tube formation
GO:0001843
IEA
Genome Projectneural tube closure
GO:0003007
IEA
Genome Projectheart morphogenesis
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007224
IEP
ISS
IEA
Genome Projectsmoothened signaling pathway
GO:0007346
IEA
Genome Projectregulation of mitotic cell cycle
GO:0007389
IEA
Genome Projectpattern specification process
GO:0007420
ISS
IEA
Genome Projectbrain development
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008544
IEA
Genome Projectepidermis development
GO:0008589
ISS
IEA
Genome Projectregulation of smoothened signaling pathway
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009887
ISS
IEA
Genome Projectorgan morphogenesis
GO:0009953
ISS
IEA
Genome Projectdorsal/ventral pattern formation
GO:0009957
IEA
Genome Projectepidermal cell fate specification
GO:0010157
IEA
Genome Projectresponse to chlorate
GO:0010875
IDA
Genome Projectpositive regulation of cholesterol efflux
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016485
ISS
IEA
Genome Projectprotein processing
GO:0021522
IEA
Genome Projectspinal cord motor neuron differentiation
GO:0021532
IMP
Genome Projectneural tube patterning
GO:0021904
IEA
Genome Projectdorsal/ventral neural tube patterning
GO:0021997
ISS
IEA
Genome Projectneural plate axis specification
GO:0030326
ISS
IEA
Genome Projectembryonic limb morphogenesis
GO:0030879
IEA
Genome Projectmammary gland development
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032526
IEA
Genome Projectresponse to retinoic acid
GO:0032880
IEA
Genome Projectregulation of protein localization
GO:0035108
IMP
Genome Projectlimb morphogenesis
GO:0035137
IEA
Genome Projecthindlimb morphogenesis
GO:0040008
IEA
Genome Projectregulation of growth
GO:0040015
ISS
IEA
Genome Projectnegative regulation of multicellular organism growth
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042593
IEA
Genome Projectglucose homeostasis
GO:0043433
IMP
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616
IEA
Genome Projectkeratinocyte proliferation
GO:0045606
IEA
Genome Projectpositive regulation of epidermal cell differentiation
GO:0045668
IMP
Genome Projectnegative regulation of osteoblast differentiation
GO:0045879
ISS
TAS
Genome Projectnegative regulation of smoothened signaling pathway
GO:0045892
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048568
IEA
Genome Projectembryonic organ development
GO:0050680
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051782
IEA
Genome Projectnegative regulation of cell division
GO:0060037
IMP
Genome Projectpharyngeal system development
GO:0060603
IEA
Genome Projectmammary gland duct morphogenesis
GO:0060644
IEA
Genome Projectmammary gland epithelial cell differentiation
GO:0060831
IEA
Genome Projectsmoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005
IEA
Genome Projectcell differentiation involved in kidney development
GO:0061053
IMP
Genome Projectsomite development
GO:0071397
IMP
ISS
Genome Projectcellular response to cholesterol
GO:0072001
IEP
Genome Projectrenal system development
GO:0072203
IEA
Genome Projectcell proliferation involved in metanephros development
GO:0072661
IDA
Genome Projectprotein targeting to plasma membrane

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005113
IEA
Genome Projectpatched binding
GO:0005119
IPI
Genome Projectsmoothened binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008158
IEA
Genome Projecthedgehog receptor activity
GO:0008201
IEA
Genome Projectheparin binding
GO:0015485
IDA
Genome Projectcholesterol binding
GO:0030332
IPI
Genome Projectcyclin binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0097108
IPI
Genome Projecthedgehog family protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005901
IDA
Genome Projectcaveola
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030496
IEA
Genome Projectmidbody
GO:0030666
TAS
Genome Projectendocytic vesicle membrane
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0044294
IEA
Genome Projectdendritic growth cone
GO:0044295
IEA
Genome Projectaxonal growth cone
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0060170
TAS
Genome Projectciliary membrane
GO:0072372
IEA
Genome Projectprimary cilium
GO:0005794
IDA
Genome ProjectGolgi apparatus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000731Sterol-sensing domain
IPR003392Patched
IPR004766Transmembrane receptor, patched

No MapMan annotations defined for this gene.