Gene: ENSG00000185652 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000185652
Transcript Identifier
ENST00000423158
Gene Type
Coding gene
Location
12 : 5432325-5494988 : positive

Family Information

Homologous gene family
HOM03P010566
(8 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P064839
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
neurotrophin 3

Identifiers

Type Value
pidENSP00000397297
HGNC8023
UniprotP20783

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0002092
IDA
Genome Projectpositive regulation of receptor internalization
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007169
IDA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007274
IEA
Genome Projectneuromuscular synaptic transmission
GO:0007399
TAS
Genome Projectnervous system development
GO:0007403
IEA
Genome Projectglial cell fate determination
GO:0007411
IEA
Genome Projectaxon guidance
GO:0007420
IEA
Genome Projectbrain development
GO:0007422
IEA
Genome Projectperipheral nervous system development
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008544
IEA
Genome Projectepidermis development
GO:0021675
IEA
Genome Projectnerve development
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0032148
IDA
Genome Projectactivation of protein kinase B activity
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0042490
IEA
Genome Projectmechanoreceptor differentiation
GO:0042981
IGI
Genome Projectregulation of apoptotic process
GO:0043523
IEA
Genome Projectregulation of neuron apoptotic process
GO:0043524
IBA
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045664
IBA
Genome Projectregulation of neuron differentiation
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048484
IEA
Genome Projectenteric nervous system development
GO:0048666
IEA
Genome Projectneuron development
GO:0048699
IEA
Genome Projectgeneration of neurons
GO:0048812
IBA
Genome Projectneuron projection morphogenesis
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050732
IDA
Genome Projectnegative regulation of peptidyl-tyrosine phosphorylation
GO:0050918
IDA
Genome Projectpositive chemotaxis
GO:0050930
IDA
Genome Projectinduction of positive chemotaxis
GO:0051145
IEA
Genome Projectsmooth muscle cell differentiation
GO:0090630
IDA
Genome Projectactivation of GTPase activity
GO:2000251
IDA
Genome Projectpositive regulation of actin cytoskeleton reorganization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
TAS, IEA
Genome Projectreceptor binding
GO:0005165
IEA
Genome Projectneurotrophin receptor binding
GO:0005166
IBA
Genome Projectneurotrophin p75 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IDA
IEA
Genome Projectgrowth factor activity
GO:0042056
IDA
Genome Projectchemoattractant activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0016023
IBA
IEA
Genome Projectcytoplasmic membrane-bounded vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002072Nerve growth factor-related
IPR015578Neurotrophin-3
IPR019846Nerve growth factor conserved site
IPR020408Nerve growth factor-like
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.