Gene: ENSG00000185345 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000185345
Transcript Identifier
ENST00000366898
Gene Type
Coding gene
Location
6 : 161350099-162727668 : negative

Family Information

Homologous gene family
HOM03P000189
(175 genes in 36 species)
specific family
Orthologous gene family
ORTHO03P029189
(4 genes in 4 species)
specific family

Descriptions

gene_descr
parkin RBR E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000355865
HGNC8607
UniprotO60260
UniprotX5DR79

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0000266
ISS
Genome Projectmitochondrial fission
GO:0000422
IDA, IMP
ISS
Genome Projectmitophagy
GO:0001933
IDA
Genome Projectnegative regulation of protein phosphorylation
GO:0001963
IEA
Genome Projectsynaptic transmission, dopaminergic
GO:0001964
IEA
Genome Projectstartle response
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006513
IDA
Genome Projectprotein monoubiquitination
GO:0006914
IEA
Genome Projectautophagy
GO:0006979
ISS
Genome Projectresponse to oxidative stress
GO:0007005
ISS
Genome Projectmitochondrion organization
GO:0007417
TAS
Genome Projectcentral nervous system development
GO:0007612
IEA
Genome Projectlearning
GO:0007626
IEA
Genome Projectlocomotory behavior
GO:0008344
ISS
IEA
Genome Projectadult locomotory behavior
GO:0010498
IMP
Genome Projectproteasomal protein catabolic process
GO:0010506
IDA
Genome Projectregulation of autophagy
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0010636
IMP
Genome Projectpositive regulation of mitochondrial fusion
GO:0010637
ISS
Genome Projectnegative regulation of mitochondrial fusion
GO:0010821
IDA, IGI
NAS
Genome Projectregulation of mitochondrion organization
GO:0010906
TAS
Genome Projectregulation of glucose metabolic process
GO:0014059
TAS
Genome Projectregulation of dopamine secretion
GO:0016567
IDA, IMP
IEA
Genome Projectprotein ubiquitination
GO:0019538
IEA
Genome Projectprotein metabolic process
GO:0031396
IMP, IGI
Genome Projectregulation of protein ubiquitination
GO:0032232
IDA
Genome Projectnegative regulation of actin filament bundle assembly
GO:0032368
TAS
Genome Projectregulation of lipid transport
GO:0032436
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033132
IDA
Genome Projectnegative regulation of glucokinase activity
GO:0034620
TAS
Genome Projectcellular response to unfolded protein
GO:0034976
IMP
Genome Projectresponse to endoplasmic reticulum stress
GO:0035249
IEA
Genome Projectsynaptic transmission, glutamatergic
GO:0035519
TAS
Genome Projectprotein K29-linked ubiquitination
GO:0036503
NAS
Genome ProjectERAD pathway
GO:0042053
IMP
Genome Projectregulation of dopamine metabolic process
GO:0042415
IEA
Genome Projectnorepinephrine metabolic process
GO:0042417
TAS, IEA
Genome Projectdopamine metabolic process
GO:0042787
IDA
TAS, NAS, IC
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123
IDA, IMP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043388
IDA
Genome Projectpositive regulation of DNA binding
GO:0043524
IDA
Genome Projectnegative regulation of neuron apoptotic process
GO:0044257
IMP
Genome Projectcellular protein catabolic process
GO:0044314
TAS
Genome Projectprotein K27-linked ubiquitination
GO:0044828
IDA
Genome Projectnegative regulation by host of viral genome replication
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046329
ISS
Genome Projectnegative regulation of JNK cascade
GO:0046676
IDA
Genome Projectnegative regulation of insulin secretion
GO:0046928
IEA
Genome Projectregulation of neurotransmitter secretion
GO:0050804
IEA
Genome Projectmodulation of synaptic transmission
GO:0050821
IMP
Genome Projectprotein stabilization
GO:0051582
IMP
Genome Projectpositive regulation of neurotransmitter uptake
GO:0051583
IEA
Genome Projectdopamine uptake involved in synaptic transmission
GO:0051865
IDA
Genome Projectprotein autoubiquitination
GO:0051881
IEA
Genome Projectregulation of mitochondrial membrane potential
GO:0055069
ISS
Genome Projectzinc ion homeostasis
GO:0060548
IDA
Genome Projectnegative regulation of cell death
GO:0070050
ISS
Genome Projectneuron cellular homeostasis
GO:0070534
IDA
TAS, NAS
Genome Projectprotein K63-linked ubiquitination
GO:0070585
IEA
Genome Projectprotein localization to mitochondrion
GO:0070842
IMP
Genome Projectaggresome assembly
GO:0070936
IDA
Genome Projectprotein K48-linked ubiquitination
GO:0070979
IDA
Genome Projectprotein K11-linked ubiquitination
GO:0071287
TAS
Genome Projectcellular response to manganese ion
GO:0085020
IDA
TAS
Genome Projectprotein K6-linked ubiquitination
GO:0090141
ISS
Genome Projectpositive regulation of mitochondrial fission
GO:0090201
IDA
Genome Projectnegative regulation of release of cytochrome c from mitochondria
GO:0097237
IMP
Genome Projectcellular response to toxic substance
GO:0098779
IDA, IMP
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1900407
IMP
ISS
Genome Projectregulation of cellular response to oxidative stress
GO:1901215
IGI
Genome Projectnegative regulation of neuron death
GO:1901800
IGI
Genome Projectpositive regulation of proteasomal protein catabolic process
GO:1902236
IDA, IMP
Genome Projectnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902283
IMP
Genome Projectnegative regulation of primary amine oxidase activity
GO:1902530
IGI
Genome Projectpositive regulation of protein linear polyubiquitination
GO:1902803
NAS
Genome Projectregulation of synaptic vesicle transport
GO:1903146
TAS
Genome Projectregulation of mitophagy
GO:1903202
TAS, NAS
Genome Projectnegative regulation of oxidative stress-induced cell death
GO:1903214
NAS
Genome Projectregulation of protein targeting to mitochondrion
GO:1903265
IDA
Genome Projectpositive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903351
TAS
Genome Projectcellular response to dopamine
GO:1903377
IDA
Genome Projectnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378
IEA
Genome Projectpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382
IEA
Genome Projectnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903861
IEA
Genome Projectpositive regulation of dendrite extension
GO:1904049
IMP
Genome Projectnegative regulation of spontaneous neurotransmitter secretion
GO:2000377
IMP
Genome Projectregulation of reactive oxygen species metabolic process
GO:2000378
IGI
Genome Projectnegative regulation of reactive oxygen species metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001664
IPI
Genome ProjectG-protein coupled receptor binding
GO:0003779
IPI
Genome Projectactin binding
GO:0004842
IDA
IEA
Genome Projectubiquitin-protein transferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
TAS, IEA
Genome Projectzinc ion binding
GO:0015631
IPI
Genome Projecttubulin binding
GO:0016874
IEA
Genome Projectligase activity
GO:0017124
TAS
Genome ProjectSH3 domain binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019900
IPI
Genome Projectkinase binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0030165
IPI
Genome ProjectPDZ domain binding
GO:0030544
IPI
Genome ProjectHsp70 protein binding
GO:0031072
IPI
Genome Projectheat shock protein binding
GO:0031624
IDA, IPI
Genome Projectubiquitin conjugating enzyme binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0043130
IDA
Genome Projectubiquitin binding
GO:0043274
IPI
Genome Projectphospholipase binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051087
IPI
Genome Projectchaperone binding
GO:0061630
IDA
NAS
Genome Projectubiquitin protein ligase activity
GO:0097602
IDA
Genome Projectcullin family protein binding
GO:1904264
NAS
Genome Projectubiquitin protein ligase activity involved in ERAD pathway
GO:1990381
IPI
Genome Projectubiquitin-specific protease binding
GO:1990444
IPI
Genome ProjectF-box domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000151
IDA
Genome Projectubiquitin ligase complex
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA, IMP
IEA
Genome Projectmitochondrion
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005829
IDA, IMP
IEA
Genome Projectcytosol
GO:0016235
IDA
Genome Projectaggresome
GO:0043005
IEA
Genome Projectneuron projection
GO:0043234
IEA
Genome Projectprotein complex
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0097413
TAS
Genome ProjectLewy body
GO:1990452
IPI
Genome ProjectParkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005
IDA
Genome ProjectSCF ubiquitin ligase complex
GO:0071797
IPI
Genome ProjectLUBAC complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000626Ubiquitin domain
IPR002867IBR domain
IPR003977E3 ubiquitin-protein ligase parkin
IPR029071Ubiquitin-related domain
IPR031127E3 ubiquitin ligase RBR family

No MapMan annotations defined for this gene.