Gene: ENSG00000184216 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000184216
Transcript Identifier
ENST00000369980
Gene Type
Coding gene
Location
X : 154011859-154019812 : negative

Family Information

Homologous gene family
HOM03P000002
(4173 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P067363
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin-1 receptor-associated kinase 1

Identifiers

Type Value
pidENSP00000358997
HGNC6112
UniprotP51617

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0001959
IMP
Genome Projectregulation of cytokine-mediated signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002376
IEA
Genome Projectimmune system process
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0007165
TAS, NAS, IEA
Genome Projectsignal transduction
GO:0007178
NAS
Genome Projecttransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007250
IDA
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0007254
TAS, IEA
Genome ProjectJNK cascade
GO:0007568
IEA
Genome Projectaging
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016567
TAS
Genome Projectprotein ubiquitination
GO:0019221
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0031663
IMP
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032088
IMP
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032494
IEA
Genome Projectresponse to peptidoglycan
GO:0032496
IMP
Genome Projectresponse to lipopolysaccharide
GO:0034134
IMP
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
IBA
TAS, IEA
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0034605
IEA
Genome Projectcellular response to heat
GO:0035556
IBA
Genome Projectintracellular signal transduction
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043123
IMP
TAS
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406
IBA
Genome Projectpositive regulation of MAP kinase activity
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0045893
NAS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0046777
IDA
NAS
Genome Projectprotein autophosphorylation
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0051092
IDA
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051259
IMP
Genome Projectprotein oligomerization
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070498
IMP
Genome Projectinterleukin-1-mediated signaling pathway
GO:0070555
IMP
Genome Projectresponse to interleukin-1
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071456
IEA
Genome Projectcellular response to hypoxia

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
TAS, IEA
Genome Projectprotein kinase activity
GO:0004674
EXP
NAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004704
TAS
Genome ProjectNF-kappaB-inducing kinase activity
GO:0004842
TAS
Genome Projectubiquitin-protein transferase activity
GO:0005149
IEA
Genome Projectinterleukin-1 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IDA
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0042803
IPI
NAS
Genome Projectprotein homodimerization activity
GO:0046982
IPI
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005811
ISS
IEA
Genome Projectlipid particle
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IBA
TAS
Genome Projectplasma membrane
GO:0010008
TAS
Genome Projectendosome membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0045323
NAS
Genome Projectinterleukin-1 receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011029Death-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.