Gene: ENSG00000183072 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000183072
Transcript Identifier
ENST00000329198
Gene Type
Coding gene
Location
5 : 173232569-173235083 : negative

Family Information

Homologous gene family
HOM03P000104
(258 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P068407
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
NK2 homeobox 5

Identifiers

Type Value
pidENSP00000327758
HGNC2488
UniprotP52952

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001570
ISS
IEA
Genome Projectvasculogenesis
GO:0001947
ISS
IEA
Genome Projectheart looping
GO:0003007
ISS
IEA
Genome Projectheart morphogenesis
GO:0003148
IMP
Genome Projectoutflow tract septum morphogenesis
GO:0003151
IEA
Genome Projectoutflow tract morphogenesis
GO:0003161
IMP
Genome Projectcardiac conduction system development
GO:0003162
IEA
Genome Projectatrioventricular node development
GO:0003166
IEA
Genome Projectbundle of His development
GO:0003168
IEA
Genome ProjectPurkinje myocyte differentiation
GO:0003208
IEA
Genome Projectcardiac ventricle morphogenesis
GO:0003211
IEA
Genome Projectcardiac ventricle formation
GO:0003221
IMP
Genome Projectright ventricular cardiac muscle tissue morphogenesis
GO:0003222
IEA
Genome Projectventricular trabecula myocardium morphogenesis
GO:0003278
IEA
Genome Projectapoptotic process involved in heart morphogenesis
GO:0003285
IMP
Genome Projectseptum secundum development
GO:0003342
IEA
Genome Projectproepicardium development
GO:0003350
IEA
Genome Projectpulmonary myocardium development
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007507
IEA
Genome Projectheart development
GO:0007512
IMP
Genome Projectadult heart development
GO:0008284
ISS
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010667
IMP
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0010735
ISS
IEA
Genome Projectpositive regulation of transcription via serum response element binding
GO:0010765
ISS
IEA
Genome Projectpositive regulation of sodium ion transport
GO:0010832
IMP
Genome Projectnegative regulation of myotube differentiation
GO:0030097
ISS
IEA
Genome Projecthemopoiesis
GO:0030154
ISS
IEA
Genome Projectcell differentiation
GO:0030509
IEA
Genome ProjectBMP signaling pathway
GO:0030878
IMP
Genome Projectthyroid gland development
GO:0035050
ISS
IEA
Genome Projectembryonic heart tube development
GO:0043066
ISS
IEA
Genome Projectnegative regulation of apoptotic process
GO:0045214
IEA
Genome Projectsarcomere organization
GO:0045666
IMP
Genome Projectpositive regulation of neuron differentiation
GO:0045823
ISS
IEA
Genome Projectpositive regulation of heart contraction
GO:0045892
ISS
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
ISS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP, IGI
ISS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048536
IMP
ISS
Genome Projectspleen development
GO:0048738
IEA
Genome Projectcardiac muscle tissue development
GO:0051891
ISS
IEA
Genome Projectpositive regulation of cardioblast differentiation
GO:0055005
IEA
Genome Projectventricular cardiac myofibril assembly
GO:0055007
ISS
IEA
Genome Projectcardiac muscle cell differentiation
GO:0055008
IMP
Genome Projectcardiac muscle tissue morphogenesis
GO:0055014
ISS
Genome Projectatrial cardiac muscle cell development
GO:0055015
ISS
Genome Projectventricular cardiac muscle cell development
GO:0055117
ISS
IEA
Genome Projectregulation of cardiac muscle contraction
GO:0060037
ISS
IEA
Genome Projectpharyngeal system development
GO:0060038
IEA
Genome Projectcardiac muscle cell proliferation
GO:0060043
IEA
Genome Projectregulation of cardiac muscle cell proliferation
GO:0060047
IEA
Genome Projectheart contraction
GO:0060048
IEA
Genome Projectcardiac muscle contraction
GO:0060070
IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060261
ISS
IEA
Genome Projectpositive regulation of transcription initiation from RNA polymerase II promoter
GO:0060347
IEA
Genome Projectheart trabecula formation
GO:0060412
IMP
Genome Projectventricular septum morphogenesis
GO:0060413
IMP
Genome Projectatrial septum morphogenesis
GO:0060928
IEA
Genome Projectatrioventricular node cell development
GO:0060929
IEA
Genome Projectatrioventricular node cell fate commitment
GO:0060971
IEA
Genome Projectembryonic heart tube left/right pattern formation
GO:0072358
IEA
Genome Projectcardiovascular system development
GO:0090090
ISS
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:1901387
IEA
Genome Projectpositive regulation of voltage-gated calcium channel activity
GO:1903779
ISS
Genome Projectregulation of cardiac conduction

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
IMP
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077
IMP
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001104
IEA
Genome ProjectRNA polymerase II transcription cofactor activity
GO:0001190
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription factor binding
GO:0001228
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003700
IDA, IMP
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003705
IEA
Genome Projecttranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0010736
ISS
IEA
Genome Projectserum response element binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0043565
IDA
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0046982
ISS
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005667
IC, IEA
Genome Projecttranscription factor complex
GO:0005737
IEA
Genome Projectcytoplasm
GO:0090575
IDA
Genome ProjectRNA polymerase II transcription factor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001356Homeobox domain
IPR009057Homeodomain-like
IPR017970Homeobox, conserved site
IPR020479Homeodomain, metazoa

No MapMan annotations defined for this gene.