Gene: ENSG00000180353 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000180353
Transcript Identifier
ENST00000314583
Gene Type
Coding gene
Location
3 : 121631846-121658347 : negative

Family Information

Homologous gene family
HOM03P018265
(4 genes in 4 species)
specific family

Descriptions

gene_descr
hematopoietic cell-specific Lyn substrate 1

Identifiers

Type Value
pidENSP00000320176
HGNC4844
UniprotP14317

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0006355
TAS
Genome Projectregulation of transcription, DNA-templated
GO:0008284
ISS
IEA
Genome Projectpositive regulation of cell proliferation
GO:0009725
ISS
IEA
Genome Projectresponse to hormone
GO:0014068
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0030041
IEA
Genome Projectactin filament polymerization
GO:0030218
ISS
IEA
Genome Projecterythrocyte differentiation
GO:0030833
IMP
Genome Projectregulation of actin filament polymerization
GO:0030854
IMP
Genome Projectpositive regulation of granulocyte differentiation
GO:0033138
IMP
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0042531
ISS
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of STAT protein
GO:0042993
IMP
Genome Projectpositive regulation of transcription factor import into nucleus
GO:0045651
IEA
Genome Projectpositive regulation of macrophage differentiation
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050731
IMP
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051897
IMP
Genome Projectpositive regulation of protein kinase B signaling
GO:0071345
IMP
Genome Projectcellular response to cytokine stimulus
GO:2000107
IMP
Genome Projectnegative regulation of leukocyte apoptotic process
GO:2000251
IC
Genome Projectpositive regulation of actin cytoskeleton reorganization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001085
IPI
Genome ProjectRNA polymerase II transcription factor binding
GO:0003779
IEA
Genome Projectactin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0017124
IEA
Genome ProjectSH3 domain binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0032403
IEA
Genome Projectprotein complex binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISS
Genome Projectnucleus
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005737
IDA
ISS
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0016020
IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001452SH3 domain
IPR003134Hs1/Cortactin
IPR028534Hematopoietic lineage cell-specific protein

No MapMan annotations defined for this gene.