Gene: ENSG00000179593 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000179593
Transcript Identifier
ENST00000380183
Gene Type
Coding gene
Location
17 : 8039156-8048565 : positive

Family Information

Homologous gene family
HOM03P000704
(78 genes in 15 species)
specific family
Orthologous gene family
ORTHO03P000181
(65 genes in 15 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
arachidonate 15-lipoxygenase, type B

Identifiers

Type Value
pidENSP00000369530
HGNC434
UniprotO15296

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006629
TAS, IEA
Genome Projectlipid metabolic process
GO:0006915
TAS
Genome Projectapoptotic process
GO:0008285
IDA, IMP
Genome Projectnegative regulation of cell proliferation
GO:0010744
IMP
Genome Projectpositive regulation of macrophage derived foam cell differentiation
GO:0019369
IDA
TAS
Genome Projectarachidonic acid metabolic process
GO:0019372
TAS, IEA
Genome Projectlipoxygenase pathway
GO:0030336
TAS
Genome Projectnegative regulation of cell migration
GO:0030850
NAS
Genome Projectprostate gland development
GO:0030856
NAS
Genome Projectregulation of epithelial cell differentiation
GO:0035360
IEA
Genome Projectpositive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0043651
IEA
Genome Projectlinoleic acid metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045618
IEA
Genome Projectpositive regulation of keratinocyte differentiation
GO:0045786
IDA
Genome Projectnegative regulation of cell cycle
GO:0045926
IDA
Genome Projectnegative regulation of growth
GO:0051122
ISS
Genome Projecthepoxilin biosynthetic process
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0090197
IMP
Genome Projectpositive regulation of chemokine secretion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005506
IDA
IEA
Genome Projectiron ion binding
GO:0005509
IDA
Genome Projectcalcium ion binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0016165
IDA
Genome Projectlinoleate 13S-lipoxygenase activity
GO:0016491
IEA
Genome Projectoxidoreductase activity
GO:0016702
IEA
Genome Projectoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0036403
IEA
Genome Projectarachidonate 8(S)-lipoxygenase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050473
IDA
IEA
Genome Projectarachidonate 15-lipoxygenase activity
GO:0051213
IEA
Genome Projectdioxygenase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IDA
Genome Projectintracellular
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
IDA
TAS, IEA
Genome Projectcytosol
GO:0005856
IDA
IEA
Genome Projectcytoskeleton
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0019898
IDA
Genome Projectextrinsic component of membrane
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000907Lipoxygenase
IPR001024PLAT/LH2 domain
IPR001885Lipoxygenase, mammalian
IPR013819Lipoxygenase, C-terminal
IPR020833Lipoxygenase, iron binding site
IPR020834Lipoxygenase, conserved site

No MapMan annotations defined for this gene.