Gene: ENSG00000179218 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000179218
Transcript Identifier
ENST00000316448
Gene Type
Coding gene
Location
19 : 12938680-12943913 : positive

Family Information

Homologous gene family
HOM03P000640
(83 genes in 38 species)
specific family
Orthologous gene family
ORTHO03P002948
(27 genes in 23 species)
specific family

Descriptions

gene_descr
calreticulin

Identifiers

Type Value
pidENSP00000320866
HGNC1455
UniprotP27797
UniprotV9HW88

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0002474
TAS
Genome Projectantigen processing and presentation of peptide antigen via MHC class I
GO:0002479
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002502
ISS
IEA
Genome Projectpeptide antigen assembly with MHC class I protein complex
GO:0006355
TAS
Genome Projectregulation of transcription, DNA-templated
GO:0006457
TAS, IEA
Genome Projectprotein folding
GO:0006611
IDA
Genome Projectprotein export from nucleus
GO:0006874
TAS
Genome Projectcellular calcium ion homeostasis
GO:0006898
TAS
Genome Projectreceptor-mediated endocytosis
GO:0007050
IGI
Genome Projectcell cycle arrest
GO:0007283
IEA
Genome Projectspermatogenesis
GO:0008284
IGI
Genome Projectpositive regulation of cell proliferation
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0017148
ISS
TAS, IEA
Genome Projectnegative regulation of translation
GO:0018279
TAS
Genome Projectprotein N-linked glycosylation via asparagine
GO:0022417
TAS
Genome Projectprotein maturation by protein folding
GO:0030866
IEA
Genome Projectcortical actin cytoskeleton organization
GO:0030968
TAS
Genome Projectendoplasmic reticulum unfolded protein response
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0033144
IDA
Genome Projectnegative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033574
IEA
Genome Projectresponse to testosterone
GO:0034504
IDA
Genome Projectprotein localization to nucleus
GO:0034975
TAS
Genome Projectprotein folding in endoplasmic reticulum
GO:0036500
TAS
Genome ProjectATF6-mediated unfolded protein response
GO:0040020
IEA
Genome Projectregulation of meiotic nuclear division
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042590
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042921
TAS
Genome Projectglucocorticoid receptor signaling pathway
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0043687
TAS
Genome Projectpost-translational protein modification
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0045665
IDA
Genome Projectnegative regulation of neuron differentiation
GO:0045740
IGI
Genome Projectpositive regulation of DNA replication
GO:0045787
IGI
Genome Projectpositive regulation of cell cycle
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0048387
IDA
Genome Projectnegative regulation of retinoic acid receptor signaling pathway
GO:0050766
ISS
IEA
Genome Projectpositive regulation of phagocytosis
GO:0050821
ISS
TAS, IEA
Genome Projectprotein stabilization
GO:0051208
TAS
Genome Projectsequestering of calcium ion
GO:0055007
IEA
Genome Projectcardiac muscle cell differentiation
GO:0061077
IEA
Genome Projectchaperone-mediated protein folding
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0071310
IEA
Genome Projectcellular response to organic substance
GO:0090398
IGI
Genome Projectcellular senescence
GO:1900026
IMP
Genome Projectpositive regulation of substrate adhesion-dependent cell spreading
GO:2000510
IMP
Genome Projectpositive regulation of dendritic cell chemotaxis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001849
TAS
Genome Projectcomplement component C1q binding
GO:0001948
IPI
IEA
Genome Projectglycoprotein binding
GO:0003677
NAS
Genome ProjectDNA binding
GO:0003729
IDA
IEA
Genome ProjectmRNA binding
GO:0005178
IPI
Genome Projectintegrin binding
GO:0005506
IEA
Genome Projectiron ion binding
GO:0005509
ISS
TAS, IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
TAS
Genome Projectzinc ion binding
GO:0030246
TAS, IEA
Genome Projectcarbohydrate binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0042277
IEA
Genome Projectpeptide binding
GO:0042562
IEA
Genome Projecthormone binding
GO:0044183
TAS
Genome Projectprotein binding involved in protein folding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050681
IDA
Genome Projectandrogen receptor binding
GO:0051082
TAS, IEA
Genome Projectunfolded protein binding
GO:0051087
TAS
Genome Projectchaperone binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005622
TAS
Genome Projectintracellular
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005783
IDA
TAS, IEA
Genome Projectendoplasmic reticulum
GO:0005788
IDA
TAS, IEA
Genome Projectendoplasmic reticulum lumen
GO:0005790
IEA
Genome Projectsmooth endoplasmic reticulum
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
IDA
IEA
Genome Projectcytosol
GO:0005844
ISS
IEA
Genome Projectpolysome
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
TAS, IEA
Genome Projectcell surface
GO:0016020
IDA
Genome Projectmembrane
GO:0016529
IEA
Genome Projectsarcoplasmic reticulum
GO:0031012
IEA
Genome Projectextracellular matrix
GO:0033018
IEA
Genome Projectsarcoplasmic reticulum lumen
GO:0042824
ISS
IEA
Genome ProjectMHC class I peptide loading complex
GO:0043231
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043234
IEA
Genome Projectprotein complex
GO:0048471
IDA
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071556
TAS
Genome Projectintegral component of lumenal side of endoplasmic reticulum membrane
GO:0071682
TAS
Genome Projectendocytic vesicle lumen

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001580Calreticulin/calnexin
IPR009033Calreticulin/calnexin, P domain
IPR009169Calreticulin
IPR013320Concanavalin A-like lectin/glucanase domain
IPR018124Calreticulin/calnexin, conserved site

No MapMan annotations defined for this gene.