Gene: ENSG00000178562 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000178562
Transcript Identifier
ENST00000458610
Gene Type
Coding gene
Location
2 : 203706524-203734912 : positive

Family Information

Homologous gene family
HOM03P027517
(3 genes in 2 species)
specific family

Descriptions

gene_descr
CD28 molecule

Identifiers

Type Value
pidENSP00000393648
HGNC1653
UniprotP10747

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002863
IEA
Genome Projectpositive regulation of inflammatory response to antigenic stimulus
GO:0006955
IEA
Genome Projectimmune response
GO:0006959
TAS
Genome Projecthumoral immune response
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0014068
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032
TAS
Genome Projectviral process
GO:0031295
TAS, IEA
Genome ProjectT cell costimulation
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0042089
TAS
Genome Projectcytokine biosynthetic process
GO:0042102
IDA
ISS
TAS
Genome Projectpositive regulation of T cell proliferation
GO:0045060
IEA
Genome Projectnegative thymic T cell selection
GO:0045066
IDA
Genome Projectregulatory T cell differentiation
GO:0045070
NAS
Genome Projectpositive regulation of viral genome replication
GO:0045086
IDA
ISS
Genome Projectpositive regulation of interleukin-2 biosynthetic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045727
NAS
Genome Projectpositive regulation of translation
GO:0045840
IDA
ISS
Genome Projectpositive regulation of mitotic nuclear division
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046641
IEA
Genome Projectpositive regulation of alpha-beta T cell proliferation
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0048304
IEA
Genome Projectpositive regulation of isotype switching to IgG isotypes
GO:0050690
TAS
Genome Projectregulation of defense response to virus by virus
GO:0050852
IEA
Genome ProjectT cell receptor signaling pathway
GO:0051897
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0097190
IEA
Genome Projectapoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
Genome Projectprotease binding
GO:0005070
IDA
Genome ProjectSH3/SH2 adaptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0015026
TAS
Genome Projectcoreceptor activity
GO:0042802
NAS
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001772
IEA
Genome Projectimmunological synapse
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007110Immunoglobulin-like domain
IPR008093T cell antigen CD28
IPR013106Immunoglobulin V-set domain
IPR013783Immunoglobulin-like fold

No MapMan annotations defined for this gene.