Gene: ENSG00000177885 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000177885
Transcript Identifier
ENST00000316804
Gene Type
Coding gene
Location
17 : 75320368-75393628 : negative

Family Information

Homologous gene family
HOM03P006490
(13 genes in 4 species)
specific family

Descriptions

gene_descr
growth factor receptor-bound protein 2

Identifiers

Type Value
pidENSP00000339007
HGNC4566
UniprotP62993
UniprotB0LPF3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007265
TAS, IEA
Genome ProjectRas protein signal transduction
GO:0007568
IEA
Genome Projectaging
GO:0009967
TAS, IEA
Genome Projectpositive regulation of signal transduction
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030838
IEA
Genome Projectpositive regulation of actin filament polymerization
GO:0043408
IEA
Genome Projectregulation of MAPK cascade
GO:0048646
IEA
Genome Projectanatomical structure formation involved in morphogenesis
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0060670
IEA
Genome Projectbranching involved in labyrinthine layer morphogenesis
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008286
IPI
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0016032
IEA
Genome Projectviral process
GO:0030168
TAS
Genome Projectplatelet activation
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0031623
IMP
Genome Projectreceptor internalization
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0042059
TAS
Genome Projectnegative regulation of epidermal growth factor receptor signaling pathway
GO:0042770
IMP
Genome Projectsignal transduction in response to DNA damage
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0071479
IMP
Genome Projectcellular response to ionizing radiation
GO:2000379
IMP
Genome Projectpositive regulation of reactive oxygen species metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001784
IEA
Genome Projectphosphotyrosine binding
GO:0005070
TAS, IEA
Genome ProjectSH3/SH2 adaptor activity
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0043560
IPI
IEA
Genome Projectinsulin receptor substrate binding
GO:0051219
IEA
Genome Projectphosphoprotein binding
GO:0005154
IPI
Genome Projectepidermal growth factor receptor binding
GO:0005168
IPI
Genome Projectneurotrophin TRKA receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0017124
IDA
Genome ProjectSH3 domain binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0046875
IPI
Genome Projectephrin receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005730
IDA
Genome Projectnucleolus
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005911
IEA
Genome Projectcell-cell junction
GO:0012506
IEA
Genome Projectvesicle membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0043234
IEA
Genome Projectprotein complex
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005768
IDA
IEA
Genome Projectendosome
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
TAS
Genome Projectcytosol
GO:0008180
IDA
Genome ProjectCOP9 signalosome
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070436
IDA
Genome ProjectGrb2-EGFR complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000980SH2 domain
IPR001452SH3 domain

No MapMan annotations defined for this gene.