Gene: ENSG00000176697 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000176697
Transcript Identifier
ENST00000438929
Gene Type
Coding gene
Location
11 : 27657821-27674284 : negative

Family Information

Homologous gene family
HOM03P010566
(8 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P072317
(2 genes in 2 species)
specific family

Descriptions

gene_descr
brain-derived neurotrophic factor

Identifiers

Type Value
pidENSP00000414303
HGNC1033
UniprotP23560

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001657
IEA
Genome Projectureteric bud development
GO:0001662
IEA
Genome Projectbehavioral fear response
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0002544
IEA
Genome Projectchronic inflammatory response
GO:0006120
IEA
Genome Projectmitochondrial electron transport, NADH to ubiquinone
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007214
IEA
Genome Projectgamma-aminobutyric acid signaling pathway
GO:0007267
IBA
Genome Projectcell-cell signaling
GO:0007399
TAS, IEA
Genome Projectnervous system development
GO:0007406
IEA
Genome Projectnegative regulation of neuroblast proliferation
GO:0007411
IEA
Genome Projectaxon guidance
GO:0007412
IEA
Genome Projectaxon target recognition
GO:0007416
IDA
Genome Projectsynapse assembly
GO:0007611
IEA
Genome Projectlearning or memory
GO:0007612
IEA
Genome Projectlearning
GO:0007631
IEA
Genome Projectfeeding behavior
GO:0008038
IEA
Genome Projectneuron recognition
GO:0009416
IEA
Genome Projectresponse to light stimulus
GO:0009642
IEA
Genome Projectresponse to light intensity
GO:0009725
IEA
Genome Projectresponse to hormone
GO:0010996
IEA
Genome Projectresponse to auditory stimulus
GO:0014047
IEA
Genome Projectglutamate secretion
GO:0014076
IEA
Genome Projectresponse to fluoxetine
GO:0014823
IEA
Genome Projectresponse to activity
GO:0016358
IEA
Genome Projectdendrite development
GO:0019222
IEA
Genome Projectregulation of metabolic process
GO:0021675
IEA
Genome Projectnerve development
GO:0030516
IEA
Genome Projectregulation of axon extension
GO:0031667
IEA
Genome Projectresponse to nutrient levels
GO:0032094
IEA
Genome Projectresponse to food
GO:0032229
IEA
Genome Projectnegative regulation of synaptic transmission, GABAergic
GO:0033138
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033189
IEA
Genome Projectresponse to vitamin A
GO:0034612
IEA
Genome Projectresponse to tumor necrosis factor
GO:0035864
IEA
Genome Projectresponse to potassium ion
GO:0042490
IEA
Genome Projectmechanoreceptor differentiation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042596
IEA
Genome Projectfear response
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043523
IEA
Genome Projectregulation of neuron apoptotic process
GO:0043524
IBA
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045664
IBA
Genome Projectregulation of neuron differentiation
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045843
IEA
Genome Projectnegative regulation of striated muscle tissue development
GO:0046668
IEA
Genome Projectregulation of retinal cell programmed cell death
GO:0048167
IEA
Genome Projectregulation of synaptic plasticity
GO:0048169
IEA
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048170
IEA
Genome Projectpositive regulation of long-term neuronal synaptic plasticity
GO:0048172
IEA
Genome Projectregulation of short-term neuronal synaptic plasticity
GO:0048668
IDA
Genome Projectcollateral sprouting
GO:0048675
IEA
Genome Projectaxon extension
GO:0048812
IBA
Genome Projectneuron projection morphogenesis
GO:0048839
IEA
Genome Projectinner ear development
GO:0050890
IEA
Genome Projectcognition
GO:0051091
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051602
IEA
Genome Projectresponse to electrical stimulus
GO:0055093
IEA
Genome Projectresponse to hyperoxia
GO:0060079
IEA
Genome Projectexcitatory postsynaptic potential
GO:0060080
IEA
Genome Projectinhibitory postsynaptic potential
GO:0060548
IEA
Genome Projectnegative regulation of cell death
GO:0061193
IEA
Genome Projecttaste bud development
GO:0071356
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071874
IEA
Genome Projectcellular response to norepinephrine stimulus
GO:0072347
IEA
Genome Projectresponse to anesthetic
GO:0097484
IEA
Genome Projectdendrite extension
GO:1901215
IEA
Genome Projectnegative regulation of neuron death
GO:1902065
IEA
Genome Projectresponse to L-glutamate
GO:1990089
IEA
Genome Projectresponse to nerve growth factor
GO:1990090
IEA
Genome Projectcellular response to nerve growth factor stimulus
GO:1990138
IEA
Genome Projectneuron projection extension
GO:2000324
IEA
Genome Projectpositive regulation of glucocorticoid receptor signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005169
IBA
IEA
Genome Projectneurotrophin TRKB receptor binding
GO:0008083
TAS, IEA
Genome Projectgrowth factor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IEA
Genome Projectextracellular space
GO:0005737
ISS
Genome Projectcytoplasm
GO:0008021
IEA
Genome Projectsynaptic vesicle
GO:0016023
IBA
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0030061
IEA
Genome Projectmitochondrial crista
GO:0030424
IEA
Genome Projectaxon
GO:0030425
IEA
Genome Projectdendrite
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0043195
IEA
Genome Projectterminal bouton
GO:0043204
IEA
Genome Projectperikaryon
GO:0048471
ISS
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002072Nerve growth factor-related
IPR019846Nerve growth factor conserved site
IPR020408Nerve growth factor-like
IPR020430Brain-derived neurotrophic factor
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.