Gene: ENSG00000175899 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000175899
Transcript Identifier
ENST00000318602
Gene Type
Coding gene
Location
12 : 9067823-9115849 : negative

Family Information

Homologous gene family
HOM03P002669
(35 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P008834
(9 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
alpha-2-macroglobulin

Identifiers

Type Value
pidENSP00000323929
HGNC7
UniprotP01023

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001869
IDA
Genome Projectnegative regulation of complement activation, lectin pathway
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007597
TAS
Genome Projectblood coagulation, intrinsic pathway
GO:0010466
IEA
Genome Projectnegative regulation of peptidase activity
GO:0010951
IDA
IEA
Genome Projectnegative regulation of endopeptidase activity
GO:0022617
TAS
Genome Projectextracellular matrix disassembly
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0048863
IEA
Genome Projectstem cell differentiation
GO:0051056
TAS
Genome Projectregulation of small GTPase mediated signal transduction

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
Genome Projectprotease binding
GO:0004866
IEA
Genome Projectendopeptidase inhibitor activity
GO:0004867
IDA
IEA
Genome Projectserine-type endopeptidase inhibitor activity
GO:0005102
IMP
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019838
IDA
Genome Projectgrowth factor binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019959
IPI
Genome Projectinterleukin-8 binding
GO:0019966
IDA
Genome Projectinterleukin-1 binding
GO:0030414
IEA
Genome Projectpeptidase inhibitor activity
GO:0043120
IDA
Genome Projecttumor necrosis factor binding
GO:0048306
IPI
Genome Projectcalcium-dependent protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, NAS, IEA
Genome Projectextracellular region
GO:0005615
IEA
Genome Projectextracellular space
GO:0005829
TAS
Genome Projectcytosol
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0072562
IDA
Genome Projectblood microparticle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001599Alpha-2-macroglobulin
IPR002890Alpha-2-macroglobulin, N-terminal
IPR008930Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR009048Alpha-macroglobulin, receptor-binding
IPR010916TonB box, conserved site
IPR011625Alpha-2-macroglobulin, N-terminal 2
IPR011626Alpha-macroglobulin complement component
IPR014756Immunoglobulin E-set
IPR019565Alpha-2-macroglobulin, thiol-ester bond-forming
IPR019742Alpha-2-macroglobulin, conserved site

No MapMan annotations defined for this gene.