Gene: ENSG00000175104 (Homo sapiens)

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Gene Identifier
ENSG00000175104
Transcript Identifier
ENST00000348124
Gene Type
Coding gene
Location
11 : 36489838-36501515 : negative

Family Information

Homologous gene family
HOM03P005260
(17 genes in 6 species)
specific family

Descriptions

gene_descr
TNF receptor-associated factor 6, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000337853
HGNC12036
UniprotQ9Y4K3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0001503
IEA
Genome Projectossification
GO:0001843
IEA
Genome Projectneural tube closure
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002376
IEA
Genome Projectimmune system process
GO:0002726
IMP
Genome Projectpositive regulation of T cell cytokine production
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006461
IEA
Genome Projectprotein complex assembly
GO:0006955
IEA
Genome Projectimmune response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007249
TAS, IEA
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007250
IMP
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0007254
TAS, IEA
Genome ProjectJNK cascade
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0019221
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0019886
IEA
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030316
IEA
Genome Projectosteoclast differentiation
GO:0031293
TAS
Genome Projectmembrane protein intracellular domain proteolysis
GO:0031398
NAS
Genome Projectpositive regulation of protein ubiquitination
GO:0031666
IEA
Genome Projectpositive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032147
IDA
Genome Projectactivation of protein kinase activity
GO:0032743
IMP
Genome Projectpositive regulation of interleukin-2 production
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042088
IEA
Genome ProjectT-helper 1 type immune response
GO:0042102
IEA
Genome Projectpositive regulation of T cell proliferation
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043011
IEA
Genome Projectmyeloid dendritic cell differentiation
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043123
IDA
TAS
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507
IDA
NAS
Genome Projectpositive regulation of JUN kinase activity
GO:0045084
IEA
Genome Projectpositive regulation of interleukin-12 biosynthetic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045410
IEA
Genome Projectpositive regulation of interleukin-6 biosynthetic process
GO:0045453
IEA
Genome Projectbone resorption
GO:0045672
IDA
Genome Projectpositive regulation of osteoclast differentiation
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IDA
NAS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046849
IEA
Genome Projectbone remodeling
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048468
IEA
Genome Projectcell development
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050852
IMP
TAS
Genome ProjectT cell receptor signaling pathway
GO:0050870
IC
Genome Projectpositive regulation of T cell activation
GO:0051023
IEA
Genome Projectregulation of immunoglobulin secretion
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092
IDA, IMP
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0051865
IDA
TAS
Genome Projectprotein autoubiquitination
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070498
IEA
Genome Projectinterleukin-1-mediated signaling pathway
GO:0070534
IDA, IGI
Genome Projectprotein K63-linked ubiquitination
GO:0070555
IDA
Genome Projectresponse to interleukin-1
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:2000679
IDA
Genome Projectpositive regulation of transcription regulatory region DNA binding

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
EXP, IDA
TAS, IEA
Genome Projectubiquitin-protein transferase activity
GO:0005164
IPI
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0031435
IPI
Genome Projectmitogen-activated protein kinase kinase kinase binding
GO:0031624
IDA
Genome Projectubiquitin conjugating enzyme binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031996
IPI
Genome Projectthioesterase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0043422
IPI
Genome Projectprotein kinase B binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0047485
IPI
Genome Projectprotein N-terminus binding
GO:0061630
IEA
Genome Projectubiquitin protein ligase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005730
IDA
Genome Projectnucleolus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005811
ISS
IEA
Genome Projectlipid particle
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005938
IEA
Genome Projectcell cortex
GO:0009898
ISS
IEA
Genome Projectcytoplasmic side of plasma membrane
GO:0010008
TAS
Genome Projectendosome membrane
GO:0035631
ISS
IEA
Genome ProjectCD40 receptor complex
GO:0043234
IDA
IEA
Genome Projectprotein complex
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001293Zinc finger, TRAF-type
IPR001841Zinc finger, RING-type
IPR002083MATH/TRAF domain
IPR008974TRAF-like
IPR012227TNF receptor-associated factor TRAF
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR017907Zinc finger, RING-type, conserved site
IPR018957Zinc finger, C3HC4 RING-type
IPR027139TNF receptor-associated factor 6

No MapMan annotations defined for this gene.