Gene: ENSG00000174405 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000174405
Transcript Identifier
ENST00000356922
Gene Type
Coding gene
Location
13 : 108208533-108211268 : negative

Family Information

Homologous gene family
HOM03P000359
(120 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001946
(34 genes in 32 species)
specific family

Descriptions

gene_descr
ligase IV, DNA, ATP-dependent

Identifiers

Type Value
pidENSP00000349393
HGNC6601
UniprotP49917
UniprotA0A024RE06

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001701
ISS
IEA
Genome Projectin utero embryonic development
GO:0002328
ISS
IEA
Genome Projectpro-B cell differentiation
GO:0006260
IEA
Genome ProjectDNA replication
GO:0006266
IDA
IEA
Genome ProjectDNA ligation
GO:0006281
TAS, IEA
Genome ProjectDNA repair
GO:0006310
IEA
Genome ProjectDNA recombination
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007417
ISS
IEA
Genome Projectcentral nervous system development
GO:0008283
ISS
IEA
Genome Projectcell proliferation
GO:0010212
IEA
Genome Projectresponse to ionizing radiation
GO:0010332
ISS
IEA
Genome Projectresponse to gamma radiation
GO:0033077
ISS
IEA
Genome ProjectT cell differentiation in thymus
GO:0033152
IBA
IEA
Genome Projectimmunoglobulin V(D)J recombination
GO:0033153
ISS
IEA
Genome ProjectT cell receptor V(D)J recombination
GO:0035019
ISS
IEA
Genome Projectsomatic stem cell population maintenance
GO:0043524
ISS
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045190
ISS
IEA
Genome Projectisotype switching
GO:0048146
ISS
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0050769
ISS
IEA
Genome Projectpositive regulation of neurogenesis
GO:0051102
ISS
IEA
Genome ProjectDNA ligation involved in DNA recombination
GO:0051103
IDA
ISS
IEA
Genome ProjectDNA ligation involved in DNA repair
GO:0051276
ISS
IEA
Genome Projectchromosome organization
GO:0051402
ISS
IEA
Genome Projectneuron apoptotic process
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0071897
IEA
Genome ProjectDNA biosynthetic process
GO:0000012
IDA
Genome Projectsingle strand break repair
GO:0006297
IDA
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006302
IDA
ISS
TAS
Genome Projectdouble-strand break repair
GO:0006303
IDA, IMP
TAS
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0007049
IEA
Genome Projectcell cycle
GO:0010165
IMP
Genome Projectresponse to X-ray
GO:0016032
TAS
Genome Projectviral process
GO:0033151
IDA
Genome ProjectV(D)J recombination
GO:0051301
IEA
Genome Projectcell division
GO:0075713
TAS
Genome Projectestablishment of integrated proviral latency
GO:0097680
IMP
Genome Projectdouble-strand break repair via classical nonhomologous end joining
GO:0006273
IBA
Genome Projectlagging strand elongation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003909
IDA
TAS, IEA
Genome ProjectDNA ligase activity
GO:0003910
IDA
IEA
Genome ProjectDNA ligase (ATP) activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016874
IDA
IEA
Genome Projectligase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0000793
IDA
Genome Projectcondensed chromosome
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005958
IDA
ISS
Genome ProjectDNA-dependent protein kinase-DNA ligase 4 complex
GO:0032807
IMP
Genome ProjectDNA ligase IV complex
GO:0070419
IDA
Genome Projectnonhomologous end joining complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000977DNA ligase, ATP-dependent
IPR001357BRCT domain
IPR012308DNA ligase, ATP-dependent, N-terminal
IPR012309DNA ligase, ATP-dependent, C-terminal
IPR012310DNA ligase, ATP-dependent, central
IPR012340Nucleic acid-binding, OB-fold
IPR016059DNA ligase, ATP-dependent, conserved site
IPR021536DNA ligase IV domain
IPR029710DNA ligase 4

No MapMan annotations defined for this gene.