Gene: ENSG00000173757 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000173757
Transcript Identifier
ENST00000293328
Gene Type
Coding gene
Location
17 : 42201738-42232127 : negative

Family Information

Homologous gene family
HOM03P007485
(11 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P038094
(3 genes in 3 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
signal transducer and activator of transcription 5B

Identifiers

Type Value
pidENSP00000293328
HGNC11367
UniprotP51692

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000255
ISS
IEA
Genome Projectallantoin metabolic process
GO:0001553
IEA
Genome Projectluteinization
GO:0001779
IEA
Genome Projectnatural killer cell differentiation
GO:0006101
ISS
IEA
Genome Projectcitrate metabolic process
GO:0006103
ISS
IEA
Genome Project2-oxoglutarate metabolic process
GO:0006105
ISS
IEA
Genome Projectsuccinate metabolic process
GO:0006107
ISS
IEA
Genome Projectoxaloacetate metabolic process
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
TAS, IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006549
ISS
IEA
Genome Projectisoleucine metabolic process
GO:0006573
ISS
IEA
Genome Projectvaline metabolic process
GO:0006600
ISS
IEA
Genome Projectcreatine metabolic process
GO:0006631
ISS
IEA
Genome Projectfatty acid metabolic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007259
TAS, IEA
Genome ProjectJAK-STAT cascade
GO:0007548
IEA
Genome Projectsex differentiation
GO:0007565
IEA
Genome Projectfemale pregnancy
GO:0007595
IEA
Genome Projectlactation
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0019218
IEA
Genome Projectregulation of steroid metabolic process
GO:0019221
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0019530
ISS
IEA
Genome Projecttaurine metabolic process
GO:0019915
IEA
Genome Projectlipid storage
GO:0030155
IEA
Genome Projectregulation of cell adhesion
GO:0030856
IEA
Genome Projectregulation of epithelial cell differentiation
GO:0032355
IDA
Genome Projectresponse to estradiol
GO:0032819
IEA
Genome Projectpositive regulation of natural killer cell proliferation
GO:0032825
IEA
Genome Projectpositive regulation of natural killer cell differentiation
GO:0032870
IDA
Genome Projectcellular response to hormone stimulus
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0038161
ISS
IEA
Genome Projectprolactin signaling pathway
GO:0040014
ISS
IEA
Genome Projectregulation of multicellular organism growth
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0042104
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042448
IEA
Genome Projectprogesterone metabolic process
GO:0043029
IEA
Genome ProjectT cell homeostasis
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0045086
IEA
Genome Projectpositive regulation of interleukin-2 biosynthetic process
GO:0045579
IEA
Genome Projectpositive regulation of B cell differentiation
GO:0045588
IEA
Genome Projectpositive regulation of gamma-delta T cell differentiation
GO:0045621
IEA
Genome Projectpositive regulation of lymphocyte differentiation
GO:0045647
IEA
Genome Projectnegative regulation of erythrocyte differentiation
GO:0045931
IEA
Genome Projectpositive regulation of mitotic cell cycle
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0045954
IEA
Genome Projectpositive regulation of natural killer cell mediated cytotoxicity
GO:0046449
ISS
IEA
Genome Projectcreatinine metabolic process
GO:0046543
IEA
Genome Projectdevelopment of secondary female sexual characteristics
GO:0046544
IEA
Genome Projectdevelopment of secondary male sexual characteristics
GO:0048541
IEA
Genome ProjectPeyer's patch development
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0060397
IDA
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:0070669
IEA
Genome Projectresponse to interleukin-2
GO:0070670
IEA
Genome Projectresponse to interleukin-4
GO:0070672
IEA
Genome Projectresponse to interleukin-15
GO:0071363
ISS
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071364
ISS
Genome Projectcellular response to epidermal growth factor stimulus
GO:0097531
IEA
Genome Projectmast cell migration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000979
IEA
Genome ProjectRNA polymerase II core promoter sequence-specific DNA binding
GO:0001077
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003682
ISS
Genome Projectchromatin binding
GO:0003700
TAS, IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0035259
IPI
Genome Projectglucocorticoid receptor binding
GO:0046983
ISS
IEA
Genome Projectprotein dimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISS
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
ISS
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000980SH2 domain
IPR001217Transcription factor STAT
IPR008967p53-like transcription factor, DNA-binding
IPR011992EF-hand domain pair
IPR012345STAT transcription factor, DNA-binding, subdomain
IPR013799STAT transcription factor, protein interaction
IPR013800STAT transcription factor, all-alpha domain
IPR013801STAT transcription factor, DNA-binding
IPR015988STAT transcription factor, coiled coil

No MapMan annotations defined for this gene.