Gene: ENSG00000173039 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000173039
Transcript Identifier
ENST00000406246
Gene Type
Coding gene
Location
11 : 65654378-65662832 : negative

Family Information

Homologous gene family
HOM03P008110
(10 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P075128
(2 genes in 2 species)
specific family

Descriptions

gene_descr
v-rel avian reticuloendotheliosis viral oncogene homolog A

Identifiers

Type Value
pidENSP00000384273
HGNC9955
UniprotQ04206

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001889
IEA
Genome Projectliver development
GO:0001942
IEA
Genome Projecthair follicle development
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006117
IEA
Genome Projectacetaldehyde metabolic process
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IDA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006952
IEA
Genome Projectdefense response
GO:0006954
IDA
Genome Projectinflammatory response
GO:0006968
NAS
Genome Projectcellular defense response
GO:0007249
IBA
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007568
IEA
Genome Projectaging
GO:0008284
IDA
IEA
Genome Projectpositive regulation of cell proliferation
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0010033
IDA
IEA
Genome Projectresponse to organic substance
GO:0010035
IEA
Genome Projectresponse to inorganic substance
GO:0010224
IDA
Genome Projectresponse to UV-B
GO:0014040
IEA
Genome Projectpositive regulation of Schwann cell differentiation
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016032
IEA
Genome Projectviral process
GO:0019221
IDA
Genome Projectcytokine-mediated signaling pathway
GO:0031293
TAS
Genome Projectmembrane protein intracellular domain proteolysis
GO:0032332
IEA
Genome Projectpositive regulation of chondrocyte differentiation
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032495
IEA
Genome Projectresponse to muramyl dipeptide
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032570
IEA
Genome Projectresponse to progesterone
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0033590
IEA
Genome Projectresponse to cobalamin
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035994
IEA
Genome Projectresponse to muscle stretch
GO:0038061
IBA
Genome ProjectNIK/NF-kappaB signaling
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042177
IEA
Genome Projectnegative regulation of protein catabolic process
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0043066
IDA
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043123
IEP
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043278
IEA
Genome Projectresponse to morphine
GO:0045084
IEA
Genome Projectpositive regulation of interleukin-12 biosynthetic process
GO:0045087
IBA
TAS
Genome Projectinnate immune response
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046627
IEA
Genome Projectnegative regulation of insulin receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050727
ISS
IEA
Genome Projectregulation of inflammatory response
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway
GO:0051092
IDA
TAS, IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051591
IEA
Genome Projectresponse to cAMP
GO:0051607
NAS
Genome Projectdefense response to virus
GO:0070301
IDA
Genome Projectcellular response to hydrogen peroxide
GO:0070431
IDA
Genome Projectnucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070555
IGI
Genome Projectresponse to interleukin-1
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071316
IMP
Genome Projectcellular response to nicotine
GO:0071347
IDA
Genome Projectcellular response to interleukin-1
GO:0071354
IMP
Genome Projectcellular response to interleukin-6
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071375
IMP
Genome Projectcellular response to peptide hormone stimulus
GO:1901223
IMP
Genome Projectnegative regulation of NIK/NF-kappaB signaling
GO:2000630
IMP
Genome Projectpositive regulation of miRNA metabolic process
GO:2001237
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000977
IDA
IEA
Genome ProjectRNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978
IDA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980
IDA
Genome ProjectRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078
IDA
Genome Projecttranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001205
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003677
IDA, IMP
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003700
IDA
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003705
IDA
Genome Projecttranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
IEA
Genome Projecttranscription factor binding
GO:0019899
IEA
Genome Projectenzyme binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0031490
IDA
Genome Projectchromatin DNA binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0033613
IPI
Genome Projectactivating transcription factor binding
GO:0042301
IDA
Genome Projectphosphate ion binding
GO:0042802
IDA, IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042805
IPI
Genome Projectactinin binding
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0047485
IPI
Genome Projectprotein N-terminus binding
GO:0051059
IPI
Genome ProjectNF-kappaB binding
GO:0070491
IPI
Genome Projectrepressing transcription factor binding
GO:0071532
IEA
Genome Projectankyrin repeat binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IBA
TAS
Genome Projectnucleoplasm
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
IDA
TAS, IEA
Genome Projectcytosol
GO:0033256
IBA
Genome ProjectI-kappaB/NF-kappaB complex
GO:0043234
IEA
Genome Projectprotein complex
GO:0071159
IEA
Genome ProjectNF-kappaB complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000451NF-kappa-B/Dorsal
IPR002909IPT domain
IPR008967p53-like transcription factor, DNA-binding
IPR011539Rel homology domain (RHD), DNA-binding domain
IPR013783Immunoglobulin-like fold
IPR014756Immunoglobulin E-set
IPR030492Rel homology domain, conserved site
IPR030495Transcription factor RelA (p65)
IPR032397Rel homology dimerisation domain

No MapMan annotations defined for this gene.