Gene: ENSG00000171862 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000171862
Transcript Identifier
ENST00000371953
Gene Type
Coding gene
Location
10 : 87864470-87965472 : positive

Family Information

Homologous gene family
HOM03P000816
(71 genes in 23 species)
specific family
Orthologous gene family
ORTHO03P005232
(16 genes in 7 species)
specific family

Descriptions

gene_descr
phosphatase and tensin homolog

Identifiers

Type Value
pidENSP00000361021
HGNC9588
UniprotP60484
UniprotF6KD01

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
IEA
Genome Projectangiogenesis
GO:0002902
IEA
Genome Projectregulation of B cell apoptotic process
GO:0006470
IDA
TAS, IEA
Genome Projectprotein dephosphorylation
GO:0007270
ISS
IEA
Genome Projectneuron-neuron synaptic transmission
GO:0007416
ISS
IEA
Genome Projectsynapse assembly
GO:0007417
ISS
IEA
Genome Projectcentral nervous system development
GO:0007507
ISS
IEA
Genome Projectheart development
GO:0007568
IEA
Genome Projectaging
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0007611
ISS
IEA
Genome Projectlearning or memory
GO:0007613
IEA
Genome Projectmemory
GO:0007626
ISS
IEA
Genome Projectlocomotory behavior
GO:0008284
ISS
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IDA, IMP
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009749
IEA
Genome Projectresponse to glucose
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010035
IEA
Genome Projectresponse to inorganic substance
GO:0010043
IEA
Genome Projectresponse to zinc ion
GO:0010975
ISS
IEA
Genome Projectregulation of neuron projection development
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016311
IEA
Genome Projectdephosphorylation
GO:0016477
ISS
IEA
Genome Projectcell migration
GO:0021542
ISS
IEA
Genome Projectdentate gyrus development
GO:0021955
ISS
IEA
Genome Projectcentral nervous system neuron axonogenesis
GO:0030336
IMP
IEA
Genome Projectnegative regulation of cell migration
GO:0030534
IEA
Genome Projectadult behavior
GO:0031175
IEA
Genome Projectneuron projection development
GO:0031642
IEA
Genome Projectnegative regulation of myelination
GO:0031647
IMP
IEA
Genome Projectregulation of protein stability
GO:0032228
IEA
Genome Projectregulation of synaptic transmission, GABAergic
GO:0032286
ISS
IEA
Genome Projectcentral nervous system myelin maintenance
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032535
ISS
IEA
Genome Projectregulation of cellular component size
GO:0033032
IEA
Genome Projectregulation of myeloid cell apoptotic process
GO:0033198
IEA
Genome Projectresponse to ATP
GO:0033555
ISS
IEA
Genome Projectmulticellular organismal response to stress
GO:0035176
ISS
IEA
Genome Projectsocial behavior
GO:0035335
IDA
IEA
Genome Projectpeptidyl-tyrosine dephosphorylation
GO:0036294
IEA
Genome Projectcellular response to decreased oxygen levels
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042711
IEA
Genome Projectmaternal behavior
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043491
ISS
IEA
Genome Projectprotein kinase B signaling
GO:0043542
IEA
Genome Projectendothelial cell migration
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045475
ISS
IEA
Genome Projectlocomotor rhythm
GO:0045792
ISS
IEA
Genome Projectnegative regulation of cell size
GO:0046621
ISS
IEA
Genome Projectnegative regulation of organ growth
GO:0046685
IEA
Genome Projectresponse to arsenic-containing substance
GO:0046855
IDA
IEA
Genome Projectinositol phosphate dephosphorylation
GO:0046856
IDA, IMP
IEA
Genome Projectphosphatidylinositol dephosphorylation
GO:0048008
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0048679
IEA
Genome Projectregulation of axon regeneration
GO:0048738
IEA
Genome Projectcardiac muscle tissue development
GO:0048853
ISS
IEA
Genome Projectforebrain morphogenesis
GO:0048854
ISS
IEA
Genome Projectbrain morphogenesis
GO:0050680
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050765
IEA
Genome Projectnegative regulation of phagocytosis
GO:0050771
ISS
IEA
Genome Projectnegative regulation of axonogenesis
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0051895
IMP
IEA
Genome Projectnegative regulation of focal adhesion assembly
GO:0051898
IMP
IEA
Genome Projectnegative regulation of protein kinase B signaling
GO:0060024
ISS
IEA
Genome Projectrhythmic synaptic transmission
GO:0060074
ISS
IEA
Genome Projectsynapse maturation
GO:0060134
ISS
IEA
Genome Projectprepulse inhibition
GO:0060179
IEA
Genome Projectmale mating behavior
GO:0060291
IEA
Genome Projectlong-term synaptic potentiation
GO:0060292
IEA
Genome Projectlong term synaptic depression
GO:0060341
IEA
Genome Projectregulation of cellular localization
GO:0060736
IEA
Genome Projectprostate gland growth
GO:0060997
ISS
IEA
Genome Projectdendritic spine morphogenesis
GO:0061002
ISS
IEA
Genome Projectnegative regulation of dendritic spine morphogenesis
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071456
IEA
Genome Projectcellular response to hypoxia
GO:0090071
IEA
Genome Projectnegative regulation of ribosome biogenesis
GO:0090344
IEA
Genome Projectnegative regulation of cell aging
GO:0090394
ISS
IEA
Genome Projectnegative regulation of excitatory postsynaptic potential
GO:0097105
ISS
IEA
Genome Projectpresynaptic membrane assembly
GO:0097107
ISS
IEA
Genome Projectpostsynaptic density assembly
GO:2000463
ISS
IEA
Genome Projectpositive regulation of excitatory postsynaptic potential
GO:2000808
ISS
IEA
Genome Projectnegative regulation of synaptic vesicle clustering
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:0000079
TAS
Genome Projectregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001933
IDA
Genome Projectnegative regulation of protein phosphorylation
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006644
TAS
Genome Projectphospholipid metabolic process
GO:0006661
TAS
Genome Projectphosphatidylinositol biosynthetic process
GO:0006915
ISS
IEA
Genome Projectapoptotic process
GO:0007092
IDA
Genome Projectactivation of APC-Cdc20 complex activity
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007399
IEA
Genome Projectnervous system development
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010467
TAS
Genome Projectgene expression
GO:0014067
TAS
Genome Projectnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0031658
IDA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0043647
TAS
Genome Projectinositol phosphate metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0060070
IDA
Genome Projectcanonical Wnt signaling pathway
GO:2000060
IDA
Genome Projectpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134
IDA
Genome Projectnegative regulation of G1/S transition of mitotic cell cycle

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000287
IEA
Genome Projectmagnesium ion binding
GO:0004725
IDA
IEA
Genome Projectprotein tyrosine phosphatase activity
GO:0005161
IEA
Genome Projectplatelet-derived growth factor receptor binding
GO:0008138
IEA
Genome Projectprotein tyrosine/serine/threonine phosphatase activity
GO:0016314
IDA
TAS, IEA
Genome Projectphosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016791
IEA
Genome Projectphosphatase activity
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0030165
IPI
IEA
Genome ProjectPDZ domain binding
GO:0051800
IDA
TAS, IEA
Genome Projectphosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438
IDA
Genome Projectphosphatidylinositol-3-phosphatase activity
GO:0004721
IDA
IEA
Genome Projectphosphoprotein phosphatase activity
GO:0004722
IDA
Genome Projectprotein serine/threonine phosphatase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0010997
IPI
Genome Projectanaphase-promoting complex binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0051717
IDA
TAS
Genome Projectinositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
TAS, IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0035749
ISS
IEA
Genome Projectmyelin sheath adaxonal region
GO:0043005
ISS
IEA
Genome Projectneuron projection
GO:0043197
IEA
Genome Projectdendritic spine
GO:0043220
ISS
IEA
Genome ProjectSchmidt-Lanterman incisure
GO:0045211
IEA
Genome Projectpostsynaptic membrane
GO:0005576
IEA
Genome Projectextracellular region
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IDA
Genome Projectplasma membrane
GO:0009898
IDA
Genome Projectcytoplasmic side of plasma membrane
GO:0016324
IMP
Genome Projectapical plasma membrane
GO:0016605
IEA
Genome ProjectPML body
GO:0042995
IDA
Genome Projectcell projection

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000008C2 domain
IPR000340Dual specificity phosphatase, catalytic domain
IPR014020Tensin phosphatase, C2 domain
IPR016130Protein-tyrosine phosphatase, active site
IPR017361Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR029021Protein-tyrosine phosphatase-like
IPR029023Tensin phosphatase, lipid phosphatase domain

No MapMan annotations defined for this gene.