Gene: ENSG00000171791 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000171791
Transcript Identifier
ENST00000333681
Gene Type
Coding gene
Location
18 : 63128625-63318666 : negative

Family Information

Homologous gene family
HOM03P011025
(7 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P065278
(2 genes in 2 species)
specific family

Descriptions

gene_descr
B-cell CLL/lymphoma 2

Identifiers

Type Value
pidENSP00000329623
HGNC990
UniprotP10415
UniprotA0A024R2B3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000902
IEA
Genome Projectcell morphogenesis
GO:0001503
IEA
Genome Projectossification
GO:0001541
IEA
Genome Projectovarian follicle development
GO:0001656
IEA
Genome Projectmetanephros development
GO:0001657
IEA
Genome Projectureteric bud development
GO:0001658
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001662
IEA
Genome Projectbehavioral fear response
GO:0001776
IEA
Genome Projectleukocyte homeostasis
GO:0001782
IEA
Genome ProjectB cell homeostasis
GO:0001822
IEA
Genome Projectkidney development
GO:0001836
ISS
NAS, IEA
Genome Projectrelease of cytochrome c from mitochondria
GO:0001952
IEA
Genome Projectregulation of cell-matrix adhesion
GO:0002260
IEA
Genome Projectlymphocyte homeostasis
GO:0002320
IEA
Genome Projectlymphoid progenitor cell differentiation
GO:0002326
IEA
Genome ProjectB cell lineage commitment
GO:0002360
IEA
Genome ProjectT cell lineage commitment
GO:0002520
IEA
Genome Projectimmune system development
GO:0002931
IEA
Genome Projectresponse to ischemia
GO:0003014
IEA
Genome Projectrenal system process
GO:0006470
IEA
Genome Projectprotein dephosphorylation
GO:0006582
IEA
Genome Projectmelanin metabolic process
GO:0006808
IEA
Genome Projectregulation of nitrogen utilization
GO:0006874
IEA
Genome Projectcellular calcium ion homeostasis
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007015
IEA
Genome Projectactin filament organization
GO:0007409
IEA
Genome Projectaxonogenesis
GO:0007569
IEA
Genome Projectcell aging
GO:0008283
IEA
Genome Projectcell proliferation
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008584
IEA
Genome Projectmale gonad development
GO:0008631
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637
IEA
Genome Projectapoptotic mitochondrial changes
GO:0009791
IEA
Genome Projectpost-embryonic development
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0010224
IEA
Genome Projectresponse to UV-B
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010506
IEA
Genome Projectregulation of autophagy
GO:0010507
TAS, IEA
Genome Projectnegative regulation of autophagy
GO:0010523
IEA
Genome Projectnegative regulation of calcium ion transport into cytosol
GO:0010559
IEA
Genome Projectregulation of glycoprotein biosynthetic process
GO:0014031
IEA
Genome Projectmesenchymal cell development
GO:0014042
IEA
Genome Projectpositive regulation of neuron maturation
GO:0014911
IEA
Genome Projectpositive regulation of smooth muscle cell migration
GO:0016049
IEA
Genome Projectcell growth
GO:0016337
IEA
Genome Projectsingle organismal cell-cell adhesion
GO:0018105
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
IEA
Genome Projectpeptidyl-threonine phosphorylation
GO:0021747
IEA
Genome Projectcochlear nucleus development
GO:0022612
IEA
Genome Projectgland morphogenesis
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0030183
IEA
Genome ProjectB cell differentiation
GO:0030217
IEA
Genome ProjectT cell differentiation
GO:0030279
IEA
Genome Projectnegative regulation of ossification
GO:0030308
IEA
Genome Projectnegative regulation of cell growth
GO:0030318
IEA
Genome Projectmelanocyte differentiation
GO:0030336
IEA
Genome Projectnegative regulation of cell migration
GO:0031069
IEA
Genome Projecthair follicle morphogenesis
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0031647
IEA
Genome Projectregulation of protein stability
GO:0032469
TAS, IEA
Genome Projectendoplasmic reticulum calcium ion homeostasis
GO:0032835
IEA
Genome Projectglomerulus development
GO:0032880
IEA
Genome Projectregulation of protein localization
GO:0033033
IEA
Genome Projectnegative regulation of myeloid cell apoptotic process
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0033138
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033689
IEA
Genome Projectnegative regulation of osteoblast proliferation
GO:0034097
IDA
IEA
Genome Projectresponse to cytokine
GO:0035265
IEA
Genome Projectorgan growth
GO:0040007
IEA
Genome Projectgrowth
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0042149
IEA
Genome Projectcellular response to glucose starvation
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043029
IEA
Genome ProjectT cell homeostasis
GO:0043066
IDA, IMP, IGI
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043067
IEA
Genome Projectregulation of programmed cell death
GO:0043085
IEA
Genome Projectpositive regulation of catalytic activity
GO:0043375
IEA
Genome ProjectCD8-positive, alpha-beta T cell lineage commitment
GO:0043473
IEA
Genome Projectpigmentation
GO:0043524
IDA
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043583
IEA
Genome Projectear development
GO:0045069
IEA
Genome Projectregulation of viral genome replication
GO:0045636
IEA
Genome Projectpositive regulation of melanocyte differentiation
GO:0045930
IEA
Genome Projectnegative regulation of mitotic cell cycle
GO:0046671
IEA
Genome Projectnegative regulation of retinal cell programmed cell death
GO:0046902
ISS
IEA
Genome Projectregulation of mitochondrial membrane permeability
GO:0048041
IEA
Genome Projectfocal adhesion assembly
GO:0048066
IEA
Genome Projectdevelopmental pigmentation
GO:0048070
IEA
Genome Projectregulation of developmental pigmentation
GO:0048087
IEA
Genome Projectpositive regulation of developmental pigmentation
GO:0048536
IEA
Genome Projectspleen development
GO:0048538
IEA
Genome Projectthymus development
GO:0048545
IEA
Genome Projectresponse to steroid hormone
GO:0048546
IEA
Genome Projectdigestive tract morphogenesis
GO:0048589
IEA
Genome Projectdevelopmental growth
GO:0048599
IEA
Genome Projectoocyte development
GO:0048743
IEA
Genome Projectpositive regulation of skeletal muscle fiber development
GO:0048753
IEA
Genome Projectpigment granule organization
GO:0048873
IEA
Genome Projecthomeostasis of number of cells within a tissue
GO:0050790
IEA
Genome Projectregulation of catalytic activity
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051402
TAS, IEA
Genome Projectneuron apoptotic process
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0051881
ISS
IEA
Genome Projectregulation of mitochondrial membrane potential
GO:0071310
IEA
Genome Projectcellular response to organic substance
GO:0071456
IEA
Genome Projectcellular response to hypoxia
GO:0072593
IEA
Genome Projectreactive oxygen species metabolic process
GO:0097192
IBA
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:2000134
IEA
Genome Projectnegative regulation of G1/S transition of mitotic cell cycle
GO:2000378
IEA
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0006915
IDA
TAS, IEA
Genome Projectapoptotic process
GO:0006959
TAS
Genome Projecthumoral immune response
GO:0006974
IMP
Genome Projectcellular response to DNA damage stimulus
GO:0007565
NAS
Genome Projectfemale pregnancy
GO:0008625
IDA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008630
IBA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314
NAS
Genome Projectresponse to radiation
GO:0009636
IDA
Genome Projectresponse to toxic substance
GO:0010039
IDA
Genome Projectresponse to iron ion
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0022898
IDA
Genome Projectregulation of transmembrane transporter activity
GO:0030307
IDA
Genome Projectpositive regulation of cell growth
GO:0030890
IMP
Genome Projectpositive regulation of B cell proliferation
GO:0032848
IDA
Genome Projectnegative regulation of cellular pH reduction
GO:0035094
IDA
Genome Projectresponse to nicotine
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042100
IDA
Genome ProjectB cell proliferation
GO:0042493
IDA, IMP
Genome Projectresponse to drug
GO:0043496
IDA
Genome Projectregulation of protein homodimerization activity
GO:0043497
IDA
Genome Projectregulation of protein heterodimerization activity
GO:0045087
TAS
Genome Projectinnate immune response
GO:0050853
IMP
Genome ProjectB cell receptor signaling pathway
GO:0051607
IDA
Genome Projectdefense response to virus
GO:0051902
TAS
Genome Projectnegative regulation of mitochondrial depolarization
GO:0051924
IDA
Genome Projectregulation of calcium ion transport
GO:0055085
IDA
Genome Projecttransmembrane transport
GO:0070059
IDA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000811
IMP
Genome Projectnegative regulation of anoikis
GO:2001234
IMP
Genome Projectnegative regulation of apoptotic signaling pathway
GO:2001240
IGI
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243
IDA
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway
GO:2001244
TAS
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008134
IEA
Genome Projecttranscription factor binding
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0051721
IEA
Genome Projectprotein phosphatase 2A binding
GO:0002020
IDA
Genome Projectprotease binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0015267
IDA
Genome Projectchannel activity
GO:0016248
IDA
Genome Projectchannel inhibitor activity
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0043565
IDA
Genome Projectsequence-specific DNA binding
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0051434
IPI
Genome ProjectBH3 domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005829
IEA
Genome Projectcytosol
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0031966
IEA
Genome Projectmitochondrial membrane
GO:0043209
IEA
Genome Projectmyelin sheath
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005741
IDA
TAS, IEA
Genome Projectmitochondrial outer membrane
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031965
IDA
IEA
Genome Projectnuclear membrane
GO:0046930
IDA
Genome Projectpore complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002475Bcl2-like
IPR003093Apoptosis regulator, Bcl-2 protein, BH4
IPR004725Apoptosis regulator, Bcl-2/ BclX
IPR013278Apoptosis regulator, Bcl-2
IPR020717Apoptosis regulator, Bcl-2, BH1 motif, conserved site
IPR020726Apoptosis regulator, Bcl-2, BH2 motif, conserved site
IPR020728Apoptosis regulator, Bcl-2, BH3 motif, conserved site
IPR020731Apoptosis regulator, Bcl-2, BH4 motif, conserved site
IPR026298Blc2 family

No MapMan annotations defined for this gene.