Gene: ENSG00000170558 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000170558
Transcript Identifier
ENST00000269141
Gene Type
Coding gene
Location
18 : 27952153-28177022 : negative

Family Information

Homologous gene family
HOM03P000124
(235 genes in 5 species)
specific family
Orthologous gene family
ORTHO03P009190
(9 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
cadherin 2, type 1, N-cadherin (neuronal)

Identifiers

Type Value
pidENSP00000269141
HGNC1759
UniprotP19022
UniprotA0A024RC42

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007155
TAS, IEA
Genome Projectcell adhesion
GO:0007156
IEA
Genome Projecthomophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157
IEA
Genome Projectheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007416
IEA
Genome Projectsynapse assembly
GO:0009966
IEA
Genome Projectregulation of signal transduction
GO:0010001
ISS
IEA
Genome Projectglial cell differentiation
GO:0016337
IEA
Genome Projectsingle organismal cell-cell adhesion
GO:0016339
IEA
Genome Projectcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016477
IEA
Genome Projectcell migration
GO:0031641
IEA
Genome Projectregulation of myelination
GO:0032880
IEA
Genome Projectregulation of protein localization
GO:0035023
IEA
Genome Projectregulation of Rho protein signal transduction
GO:0043410
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0044331
ISS
IEA
Genome Projectcell-cell adhesion mediated by cadherin
GO:0048514
IEA
Genome Projectblood vessel morphogenesis
GO:0050770
IEA
Genome Projectregulation of axonogenesis
GO:0051146
IEA
Genome Projectstriated muscle cell differentiation
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0090090
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0097118
IEA
Genome Projectneuroligin clustering involved in postsynaptic membrane assembly
GO:0097150
ISS
IEA
Genome Projectneuronal stem cell population maintenance
GO:1902897
IEA
Genome Projectregulation of postsynaptic density protein 95 clustering
GO:2000809
IEA
Genome Projectpositive regulation of synaptic vesicle clustering
GO:0034329
TAS
Genome Projectcell junction assembly
GO:0034332
TAS
Genome Projectadherens junction organization
GO:0042692
TAS
Genome Projectmuscle cell differentiation
GO:0045216
TAS
Genome Projectcell-cell junction organization
GO:0051149
TAS
Genome Projectpositive regulation of muscle cell differentiation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0008013
TAS, IEA
Genome Projectbeta-catenin binding
GO:0019899
IEA
Genome Projectenzyme binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0050998
IEA
Genome Projectnitric-oxide synthase binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0045294
IPI
Genome Projectalpha-catenin binding
GO:0045295
IPI
Genome Projectgamma-catenin binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005912
IEA
Genome Projectadherens junction
GO:0005913
IDA
IEA
Genome Projectcell-cell adherens junction
GO:0005916
IEA
Genome Projectfascia adherens
GO:0014704
ISS
IEA
Genome Projectintercalated disc
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
IEA
Genome Projectbasolateral plasma membrane
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0030027
IDA
IEA
Genome Projectlamellipodium
GO:0043234
IEA
Genome Projectprotein complex
GO:0045202
IEA
Genome Projectsynapse
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0016342
IDA
Genome Projectcatenin complex
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0030864
IDA
Genome Projectcortical actin cytoskeleton

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000233Cadherin, cytoplasmic domain
IPR002126Cadherin
IPR014868Cadherin prodomain
IPR015919Cadherin-like
IPR020894Cadherin conserved site
IPR027397Catenin binding domain
IPR030051N-cadherin

No MapMan annotations defined for this gene.