Gene: ENSG00000169760 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000169760
Transcript Identifier
ENST00000361589
Gene Type
Coding gene
Location
3 : 173604599-174281303 : positive

Family Information

Homologous gene family
HOM03P000191
(174 genes in 16 species)
specific family
Orthologous gene family
ORTHO03P008154
(10 genes in 4 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
neuroligin 1

Identifiers

Type Value
pidENSP00000354541
HGNC14291
UniprotQ8N2Q7

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002087
IEA
Genome Projectregulation of respiratory gaseous exchange by neurological system process
GO:0006605
ISS
IEA
Genome Projectprotein targeting
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007157
ISS
IEA
Genome Projectheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007158
ISS
TAS, IEA
Genome Projectneuron cell-cell adhesion
GO:0007399
ISS
IEA
Genome Projectnervous system development
GO:0007416
ISS
IEA
Genome Projectsynapse assembly
GO:0010841
ISS
IEA
Genome Projectpositive regulation of circadian sleep/wake cycle, wakefulness
GO:0016080
ISS
IEA
Genome Projectsynaptic vesicle targeting
GO:0016339
ISS
IEA
Genome Projectcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0023041
TAS
Genome Projectneuronal signal transduction
GO:0031175
IDA
Genome Projectneuron projection development
GO:0032230
ISS
IEA
Genome Projectpositive regulation of synaptic transmission, GABAergic
GO:0035418
ISS
IEA
Genome Projectprotein localization to synapse
GO:0045184
ISS
IEA
Genome Projectestablishment of protein localization
GO:0045664
ISS
IEA
Genome Projectregulation of neuron differentiation
GO:0048488
IBA
Genome Projectsynaptic vesicle endocytosis
GO:0048489
IEA
Genome Projectsynaptic vesicle transport
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048789
ISS
IEA
Genome Projectcytoskeletal matrix organization at active zone
GO:0050804
IBA
IEA
Genome Projectmodulation of synaptic transmission
GO:0050808
IEA
Genome Projectsynapse organization
GO:0051260
ISS
IEA
Genome Projectprotein homooligomerization
GO:0051290
IEA
Genome Projectprotein heterotetramerization
GO:0051491
ISS
IEA
Genome Projectpositive regulation of filopodium assembly
GO:0051965
IDA
ISS
IEA
Genome Projectpositive regulation of synapse assembly
GO:0051968
ISS
IEA
Genome Projectpositive regulation of synaptic transmission, glutamatergic
GO:0060291
IEA
Genome Projectlong-term synaptic potentiation
GO:0060999
IGI
ISS
IEA
Genome Projectpositive regulation of dendritic spine development
GO:0061002
IGI
IEA
Genome Projectnegative regulation of dendritic spine morphogenesis
GO:0072553
ISS
IEA
Genome Projectterminal button organization
GO:0097091
ISS
IEA
Genome Projectsynaptic vesicle clustering
GO:0097104
ISS, IBA
IEA
Genome Projectpostsynaptic membrane assembly
GO:0097105
ISS, IBA
IEA
Genome Projectpresynaptic membrane assembly
GO:0097113
ISS
IEA
Genome ProjectAMPA glutamate receptor clustering
GO:0097114
ISS
IEA
Genome ProjectNMDA glutamate receptor clustering
GO:0097115
ISS
IEA
Genome Projectneurexin clustering involved in presynaptic membrane assembly
GO:0097119
ISS
IEA
Genome Projectpostsynaptic density protein 95 clustering
GO:0097120
ISS
IEA
Genome Projectreceptor localization to synapse
GO:1900029
ISS
IEA
Genome Projectpositive regulation of ruffle assembly
GO:1900244
ISS
IEA
Genome Projectpositive regulation of synaptic vesicle endocytosis
GO:1902474
IEA
Genome Projectpositive regulation of protein localization to synapse
GO:1902533
ISS
IEA
Genome Projectpositive regulation of intracellular signal transduction
GO:2000302
ISS
IEA
Genome Projectpositive regulation of synaptic vesicle exocytosis
GO:2000310
IGI
ISS
IEA
Genome Projectregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311
ISS
IEA
Genome Projectregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463
IGI
ISS
IEA
Genome Projectpositive regulation of excitatory postsynaptic potential
GO:2000809
IEA
Genome Projectpositive regulation of synaptic vesicle clustering
GO:0006581
IBA
Genome Projectacetylcholine catabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004872
ISS, IBA
IEA
Genome Projectreceptor activity
GO:0030165
IDA
Genome ProjectPDZ domain binding
GO:0042043
ISS, IBA
IEA
Genome Projectneurexin family protein binding
GO:0046983
ISS
IEA
Genome Projectprotein dimerization activity
GO:0050839
ISS
IEA
Genome Projectcell adhesion molecule binding
GO:0097110
IDA
Genome Projectscaffold protein binding
GO:0004104
IBA
Genome Projectcholinesterase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005794
ISS
IEA
Genome ProjectGolgi apparatus
GO:0005886
ISS
IEA
Genome Projectplasma membrane
GO:0005887
ISS, IBA
IEA
Genome Projectintegral component of plasma membrane
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
ISS, IBA
IEA
Genome Projectcell surface
GO:0014069
ISS
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0017146
IEA
Genome ProjectNMDA selective glutamate receptor complex
GO:0030054
IEA
Genome Projectcell junction
GO:0030425
ISS
IEA
Genome Projectdendrite
GO:0032433
ISS
IEA
Genome Projectfilopodium tip
GO:0043197
ISS
IEA
Genome Projectdendritic spine
GO:0043198
IEA
Genome Projectdendritic shaft
GO:0045202
ISS
IEA
Genome Projectsynapse
GO:0045211
IEA
Genome Projectpostsynaptic membrane
GO:0060076
IEA
Genome Projectexcitatory synapse
GO:0097481
TAS
Genome Projectneuronal postsynaptic density
GO:0005615
IBA
Genome Projectextracellular space

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000460Neuroligin
IPR002018Carboxylesterase, type B
IPR019819Carboxylesterase type B, conserved site
IPR029058Alpha/Beta hydrolase fold
IPR030022Neuroligin-1

No MapMan annotations defined for this gene.