Gene: ENSG00000169245 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000169245
Transcript Identifier
ENST00000306602
Gene Type
Coding gene
Location
4 : 76021930-76023431 : negative

Family Information

Homologous gene family
HOM03P006025
(15 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P031011
(3 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
chemokine (C-X-C motif) ligand 10

Identifiers

Type Value
pidENSP00000305651
HGNC10637
UniprotP02778
UniprotA0A024RDA4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002690
IEA
Genome Projectpositive regulation of leukocyte chemotaxis
GO:0006935
IDA
TAS, IEA
Genome Projectchemotaxis
GO:0006955
IBA
IEA
Genome Projectimmune response
GO:0008284
TAS, IEA
Genome Projectpositive regulation of cell proliferation
GO:0009409
IEA
Genome Projectresponse to cold
GO:0009615
IEA
Genome Projectresponse to virus
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010996
IEA
Genome Projectresponse to auditory stimulus
GO:0016525
IEA
Genome Projectnegative regulation of angiogenesis
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0033280
IEA
Genome Projectresponse to vitamin D
GO:0034605
IEA
Genome Projectcellular response to heat
GO:0045662
IEA
Genome Projectnegative regulation of myoblast differentiation
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0060326
IEA
Genome Projectcell chemotaxis
GO:1901740
IEA
Genome Projectnegative regulation of myoblast fusion
GO:0006954
TAS, IEA
Genome Projectinflammatory response
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007186
IMP
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007517
TAS
Genome Projectmuscle organ development
GO:0008015
TAS
Genome Projectblood circulation
GO:0010818
IMP
Genome ProjectT cell chemotaxis
GO:0010819
IDA
Genome Projectregulation of T cell chemotaxis
GO:0030816
IDA
Genome Projectpositive regulation of cAMP metabolic process
GO:0042118
IGI
Genome Projectendothelial cell activation
GO:0042127
IDA
Genome Projectregulation of cell proliferation
GO:0043950
IDA
Genome Projectpositive regulation of cAMP-mediated signaling
GO:0045859
TAS
Genome Projectregulation of protein kinase activity
GO:0045944
TAS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0051281
IDA
Genome Projectpositive regulation of release of sequestered calcium ion into cytosol
GO:0070098
IMP
Genome Projectchemokine-mediated signaling pathway
GO:0071222
IMP
Genome Projectcellular response to lipopolysaccharide
GO:0090026
IDA
Genome Projectpositive regulation of monocyte chemotaxis
GO:1901509
IDA
Genome Projectregulation of endothelial tube morphogenesis
GO:2000406
IDA
Genome Projectpositive regulation of T cell migration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IEA
Genome Projectcytokine activity
GO:0008009
IDA
TAS, IEA
Genome Projectchemokine activity
GO:0005102
TAS
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008201
IMP
Genome Projectheparin binding
GO:0008603
TAS
Genome ProjectcAMP-dependent protein kinase regulator activity
GO:0048248
IDA
Genome ProjectCXCR3 chemokine receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
TAS, IEA
Genome Projectextracellular region
GO:0005615
IBA
IEA
Genome Projectextracellular space
GO:0009897
IEA
Genome Projectexternal side of plasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001089CXC chemokine
IPR001811Chemokine interleukin-8-like domain
IPR018048CXC chemokine, conserved site
IPR027220CXC chemokine 10

No MapMan annotations defined for this gene.