Gene: ENSG00000169047 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000169047
Transcript Identifier
ENST00000305123
Gene Type
Coding gene
Location
2 : 226795010-226798738 : negative

Family Information

Homologous gene family
HOM03P009147
(9 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P076064
(2 genes in 2 species)
specific family

Descriptions

gene_descr
insulin receptor substrate 1

Identifiers

Type Value
pidENSP00000304895
HGNC6125
UniprotP35568
UniprotA0A024R499

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0016042
IEA
Genome Projectlipid catabolic process
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0030879
IEA
Genome Projectmammary gland development
GO:0034504
IEA
Genome Projectprotein localization to nucleus
GO:0043491
IEA
Genome Projectprotein kinase B signaling
GO:0043552
ISS
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0008284
NAS
Genome Projectpositive regulation of cell proliferation
GO:0008286
IDA, IPI, IMP
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010907
IMP
Genome Projectpositive regulation of glucose metabolic process
GO:0014065
IDA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0032000
IMP
Genome Projectpositive regulation of fatty acid beta-oxidation
GO:0032868
IDA
Genome Projectresponse to insulin
GO:0032869
IMP
Genome Projectcellular response to insulin stimulus
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0042593
TAS
Genome Projectglucose homeostasis
GO:0043434
ISS
Genome Projectresponse to peptide hormone
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045725
IMP
NAS
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0046326
IMP
Genome Projectpositive regulation of glucose import
GO:0046627
ISS
Genome Projectnegative regulation of insulin receptor signaling pathway
GO:0046628
ISS
Genome Projectpositive regulation of insulin receptor signaling pathway
GO:0046676
IDA
Genome Projectnegative regulation of insulin secretion
GO:0048009
IPI
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0060397
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:2001275
IDA
Genome Projectpositive regulation of glucose import in response to insulin stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005158
IPI
IEA
Genome Projectinsulin receptor binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0004871
TAS, IEA
Genome Projectsignal transducer activity
GO:0005068
ISS
TAS
Genome Projecttransmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080
ISS
Genome Projectprotein kinase C binding
GO:0005159
IPI
Genome Projectinsulin-like growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0042169
ISS
Genome ProjectSH2 domain binding
GO:0043548
IPI
ISS
Genome Projectphosphatidylinositol 3-kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISS
IEA
Genome Projectnucleus
GO:0005737
ISS
TAS, IEA
Genome Projectcytoplasm
GO:0005886
IBA
TAS, IEA
Genome Projectplasma membrane
GO:0036064
IEA
Genome Projectciliary basal body
GO:0005829
IBA
TAS
Genome Projectcytosol
GO:0005899
ISS
Genome Projectinsulin receptor complex
GO:0005901
IDA
Genome Projectcaveola
GO:0043231
ISS
Genome Projectintracellular membrane-bounded organelle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001849Pleckstrin homology domain
IPR002404IRS-type PTB domain
IPR011993PH domain-like

No MapMan annotations defined for this gene.