Gene: ENSG00000168621 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000168621
Transcript Identifier
ENST00000427982
Gene Type
Coding gene
Location
5 : 37815651-37835658 : negative

Family Information

Homologous gene family
HOM03P021792
(4 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P067738
(2 genes in 2 species)
specific family

Descriptions

gene_descr
glial cell derived neurotrophic factor

Identifiers

Type Value
pidENSP00000409007
HGNC4232
UniprotP39905

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001656
ISS
IEA
Genome Projectmetanephros development
GO:0001657
IEA
Genome Projectureteric bud development
GO:0001658
ISS
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001755
IDA
Genome Projectneural crest cell migration
GO:0001759
IEA
Genome Projectorgan induction
GO:0001941
IEA
Genome Projectpostsynaptic membrane organization
GO:0003337
IEA
Genome Projectmesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007399
TAS, IEA
Genome Projectnervous system development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007422
IEA
Genome Projectperipheral nervous system development
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008344
TAS
Genome Projectadult locomotory behavior
GO:0010468
IGI
Genome Projectregulation of gene expression
GO:0021784
ISS
IEA
Genome Projectpostganglionic parasympathetic fiber development
GO:0030432
ISS
IEA
Genome Projectperistalsis
GO:0031175
IDA
Genome Projectneuron projection development
GO:0032770
IDA
Genome Projectpositive regulation of monooxygenase activity
GO:0033603
TAS
Genome Projectpositive regulation of dopamine secretion
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043524
IDA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045597
IGI
Genome Projectpositive regulation of cell differentiation
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048255
IDA
Genome ProjectmRNA stabilization
GO:0048484
ISS
IEA
Genome Projectenteric nervous system development
GO:0048485
ISS
IEA
Genome Projectsympathetic nervous system development
GO:0051584
IDA
Genome Projectregulation of dopamine uptake involved in synaptic transmission
GO:0060676
IEA
Genome Projectureteric bud formation
GO:0060688
ISS
IEA
Genome Projectregulation of morphogenesis of a branching structure
GO:0072107
IDA
Genome Projectpositive regulation of ureteric bud formation
GO:0072108
IEA
Genome Projectpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0090190
IDA
Genome Projectpositive regulation of branching involved in ureteric bud morphogenesis
GO:2000736
TAS
Genome Projectregulation of stem cell differentiation
GO:2001240
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
TAS
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0042803
IDA
Genome Projectprotein homodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
IEA
Genome Projectextracellular region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001839Transforming growth factor-beta, C-terminal
IPR016649Glial cell line-derived neurotrophic factor
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.