Gene: ENSG00000168610 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000168610
Transcript Identifier
ENST00000588969
Gene Type
Coding gene
Location
17 : 42315745-42348516 : negative

Family Information

Homologous gene family
HOM03P007485
(11 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P018601
(5 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
signal transducer and activator of transcription 3 (acute-phase response factor)

Identifiers

Type Value
pidENSP00000467985
HGNC11364
UniprotP40763

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
TAS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001659
ISS
IEA
Genome Projecttemperature homeostasis
GO:0001754
ISS
IEA
Genome Projecteye photoreceptor cell differentiation
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IDA
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
ISS
TAS
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006606
IDA
Genome Projectprotein import into nucleus
GO:0006928
TAS
Genome Projectmovement of cell or subcellular component
GO:0006953
IEA
Genome Projectacute-phase response
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007259
TAS
Genome ProjectJAK-STAT cascade
GO:0007399
TAS
Genome Projectnervous system development
GO:0007568
IEA
Genome Projectaging
GO:0008283
IEA
Genome Projectcell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010730
IEA
Genome Projectnegative regulation of hydrogen peroxide biosynthetic process
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016032
IEA
Genome Projectviral process
GO:0016310
ISS
IEA
Genome Projectphosphorylation
GO:0019221
NAS
Genome Projectcytokine-mediated signaling pathway
GO:0019827
IEA
Genome Projectstem cell population maintenance
GO:0019953
ISS
IEA
Genome Projectsexual reproduction
GO:0030522
IDA
Genome Projectintracellular receptor signaling pathway
GO:0032355
IDA
IEA
Genome Projectresponse to estradiol
GO:0032870
IDA
Genome Projectcellular response to hormone stimulus
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0035019
TAS
Genome Projectsomatic stem cell population maintenance
GO:0040014
IEA
Genome Projectregulation of multicellular organism growth
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042593
ISS
IEA
Genome Projectglucose homeostasis
GO:0042755
ISS
IEA
Genome Projecteating behavior
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045747
ISS
IEA
Genome Projectpositive regulation of Notch signaling pathway
GO:0045820
IEA
Genome Projectnegative regulation of glycolytic process
GO:0045893
IMP
ISS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046902
IEA
Genome Projectregulation of mitochondrial membrane permeability
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048708
ISS
IEA
Genome Projectastrocyte differentiation
GO:0060019
ISS
IEA
Genome Projectradial glial cell differentiation
GO:0060396
IDA
Genome Projectgrowth hormone receptor signaling pathway
GO:0060397
IDA
ISS
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548
IEA
Genome Projectnegative regulation of cell death
GO:0070102
IDA, IMP
Genome Projectinterleukin-6-mediated signaling pathway
GO:1901215
IEA
Genome Projectnegative regulation of neuron death
GO:1902728
IEA
Genome Projectpositive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:2001171
IEA
Genome Projectpositive regulation of ATP biosynthetic process
GO:2001223
IEA
Genome Projectnegative regulation of neuron migration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
IDA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981
IEA
Genome ProjectRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077
IMP
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001103
IPI
Genome ProjectRNA polymerase II repressing transcription factor binding
GO:0001228
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677
ISS
IEA
Genome ProjectDNA binding
GO:0003700
TAS, IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0004871
TAS, IEA
Genome Projectsignal transducer activity
GO:0004879
IDA
Genome ProjectRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
IEA
Genome Projecttranscription factor binding
GO:0019901
ISS
IEA
Genome Projectprotein kinase binding
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0031730
IEA
Genome ProjectCCR5 chemokine receptor binding
GO:0035259
IEA
Genome Projectglucocorticoid receptor binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding
GO:0046983
ISS
IEA
Genome Projectprotein dimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005634
IDA
ISS
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
ISS
TAS, IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005743
IEA
Genome Projectmitochondrial inner membrane
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
ISS
IEA
Genome Projectplasma membrane
GO:0090575
IMP
IC
Genome ProjectRNA polymerase II transcription factor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000980SH2 domain
IPR001217Transcription factor STAT
IPR008967p53-like transcription factor, DNA-binding
IPR011992EF-hand domain pair
IPR012345STAT transcription factor, DNA-binding, subdomain
IPR013799STAT transcription factor, protein interaction
IPR013800STAT transcription factor, all-alpha domain
IPR013801STAT transcription factor, DNA-binding
IPR015988STAT transcription factor, coiled coil

No MapMan annotations defined for this gene.