Gene: ENSG00000168040 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000168040
Transcript Identifier
ENST00000301838
Gene Type
Coding gene
Location
11 : 70203460-70206473 : positive

Family Information

Homologous gene family
HOM03P037259
(2 genes in 2 species)
specific family

Descriptions

gene_descr
Fas (TNFRSF6)-associated via death domain

Identifiers

Type Value
pidENSP00000301838
HGNC3573
UniprotQ13158

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001916
ISS
IEA
Genome Projectpositive regulation of T cell mediated cytotoxicity
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002376
IEA
Genome Projectimmune system process
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0002821
ISS
IEA
Genome Projectpositive regulation of adaptive immune response
GO:0006915
IMP
TAS, IEA
Genome Projectapoptotic process
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0008625
TAS
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0010939
TAS
Genome Projectregulation of necrotic cell death
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016032
IEA
Genome Projectviral process
GO:0032729
ISS
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033077
ISS
IEA
Genome ProjectT cell differentiation in thymus
GO:0033209
TAS
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0036462
IDA
Genome ProjectTRAIL-activated apoptotic signaling pathway
GO:0042104
ISS
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043029
ISS
IEA
Genome ProjectT cell homeostasis
GO:0043065
IMP
Genome Projectpositive regulation of apoptotic process
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0045651
IMP
Genome Projectpositive regulation of macrophage differentiation
GO:0045862
IDA
Genome Projectpositive regulation of proteolysis
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048535
ISS
IEA
Genome Projectlymph node development
GO:0048536
ISS
IEA
Genome Projectspleen development
GO:0048538
ISS
IEA
Genome Projectthymus development
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051607
IMP
Genome Projectdefense response to virus
GO:0060340
IMP
Genome Projectpositive regulation of type I interferon-mediated signaling pathway
GO:0060546
IEA
Genome Projectnegative regulation of necroptotic process
GO:0070236
ISS
IEA
Genome Projectnegative regulation of activation-induced cell death of T cells
GO:0070266
TAS
Genome Projectnecroptotic process
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0097049
IEA
Genome Projectmotor neuron apoptotic process
GO:0097190
IDA
TAS
Genome Projectapoptotic signaling pathway
GO:0097191
IDA, IMP
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097202
IDA
Genome Projectactivation of cysteine-type endopeptidase activity
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300
TAS
Genome Projectprogrammed necrotic cell death
GO:0097527
IMP
Genome Projectnecroptotic signaling pathway
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454
ISS
IEA
Genome Projectpositive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
IEA
Genome Projectprotease binding
GO:0005123
TAS, IEA
Genome Projectdeath receptor binding
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0032813
IPI
Genome Projecttumor necrosis factor receptor superfamily binding
GO:0035877
IPI
Genome Projectdeath effector domain binding
GO:0042802
IPI
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0031264
IDA
TAS, IEA
Genome Projectdeath-inducing signaling complex
GO:0031265
IDA
IEA
Genome ProjectCD95 death-inducing signaling complex
GO:0043005
IEA
Genome Projectneuron projection
GO:0043234
IEA
Genome Projectprotein complex
GO:0044297
IEA
Genome Projectcell body
GO:0045121
IEA
Genome Projectmembrane raft
GO:0097342
IDA
Genome Projectripoptosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR001875Death effector domain
IPR011029Death-like domain
IPR016729FADD

No MapMan annotations defined for this gene.