Gene: ENSG00000167207 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000167207
Transcript Identifier
ENST00000300589
Gene Type
Coding gene
Location
16 : 50697244-50731819 : positive

Family Information

Homologous gene family
HOM03P000077
(337 genes in 34 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
nucleotide-binding oligomerization domain containing 2

Identifiers

Type Value
pidENSP00000300589
HGNC5331
UniprotQ9HC29

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002227
IEA
Genome Projectinnate immune response in mucosa
GO:0002253
IEA
Genome Projectactivation of immune response
GO:0002367
IMP
Genome Projectcytokine production involved in immune response
GO:0002374
IMP
Genome Projectcytokine secretion involved in immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002381
IEA
Genome Projectimmunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606
ISS
Genome Projectpositive regulation of dendritic cell antigen processing and presentation
GO:0002710
IEA
Genome Projectnegative regulation of T cell mediated immunity
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0002830
IMP
Genome Projectpositive regulation of type 2 immune response
GO:0002862
IEA
Genome Projectnegative regulation of inflammatory response to antigenic stimulus
GO:0002925
IEA
Genome Projectpositive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006952
TAS
Genome Projectdefense response
GO:0006963
IEA
Genome Projectpositive regulation of antibacterial peptide biosynthetic process
GO:0006965
IEA
Genome Projectpositive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007254
TAS
Genome ProjectJNK cascade
GO:0009595
TAS
Genome Projectdetection of biotic stimulus
GO:0016045
IDA
Genome Projectdetection of bacterium
GO:0030277
IMP
Genome Projectmaintenance of gastrointestinal epithelium
GO:0032088
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032494
IEA
Genome Projectresponse to peptidoglycan
GO:0032495
IDA, IMP
Genome Projectresponse to muramyl dipeptide
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032498
IDA
Genome Projectdetection of muramyl dipeptide
GO:0032689
IEA
Genome Projectnegative regulation of interferon-gamma production
GO:0032695
IEA
Genome Projectnegative regulation of interleukin-12 production
GO:0032701
IEA
Genome Projectnegative regulation of interleukin-18 production
GO:0032703
IEA
Genome Projectnegative regulation of interleukin-2 production
GO:0032720
IEA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032731
IMP
Genome Projectpositive regulation of interleukin-1 beta production
GO:0032733
ISS
Genome Projectpositive regulation of interleukin-10 production
GO:0032735
IEA
Genome Projectpositive regulation of interleukin-12 production
GO:0032740
IMP
Genome Projectpositive regulation of interleukin-17 production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
IMP
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
IDA, IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032874
IDA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034136
IEA
Genome Projectnegative regulation of toll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035419
ISS
Genome Projectactivation of MAPK activity involved in innate immune response
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042742
IDA
Genome Projectdefense response to bacterium
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330
IEA
Genome Projectresponse to exogenous dsRNA
GO:0043410
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0043552
ISS
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0044130
IEA
Genome Projectnegative regulation of growth of symbiont in host
GO:0045087
IDA
TAS, NAS, IEA
Genome Projectinnate immune response
GO:0045089
IEA
Genome Projectpositive regulation of innate immune response
GO:0045747
ISS
Genome Projectpositive regulation of Notch signaling pathway
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IDA
Genome Projectpositive regulation of JNK cascade
GO:0046645
ISS
Genome Projectpositive regulation of gamma-delta T cell activation
GO:0050679
ISS
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050718
IDA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050727
IC, IEA
Genome Projectregulation of inflammatory response
GO:0050731
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050766
IEA
Genome Projectpositive regulation of phagocytosis
GO:0050830
IEA
Genome Projectdefense response to Gram-positive bacterium
GO:0050871
IDA
Genome Projectpositive regulation of B cell activation
GO:0051092
IDA, IMP
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051259
TAS
Genome Projectprotein oligomerization
GO:0051353
ISS
Genome Projectpositive regulation of oxidoreductase activity
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0051770
ISS
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0060585
ISS
Genome Projectpositive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374
ISS
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070431
IDA
Genome Projectnucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224
IEA
Genome Projectcellular response to peptidoglycan
GO:0071225
IDA, IMP
Genome Projectcellular response to muramyl dipeptide
GO:0071608
IEA
Genome Projectmacrophage inflammatory protein-1 alpha production
GO:0090022
IEA
Genome Projectregulation of neutrophil chemotaxis
GO:1900017
IDA
Genome Projectpositive regulation of cytokine production involved in inflammatory response
GO:1901224
IMP
Genome Projectpositive regulation of NIK/NF-kappaB signaling
GO:2000110
ISS
Genome Projectnegative regulation of macrophage apoptotic process
GO:2000363
ISS
Genome Projectpositive regulation of prostaglandin-E synthase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003779
IDA
Genome Projectactin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0030544
IPI
Genome ProjectHsp70 protein binding
GO:0032500
IDA
Genome Projectmuramyl dipeptide binding
GO:0042834
IDA
Genome Projectpeptidoglycan binding
GO:0050700
IPI
Genome ProjectCARD domain binding
GO:0051879
IDA
Genome ProjectHsp90 protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
TAS, IEA
Genome Projectcytoplasm
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005856
IDA
Genome Projectcytoskeleton
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016323
IDA
IEA
Genome Projectbasolateral plasma membrane
GO:0031982
IDA
Genome Projectvesicle
GO:0043234
IDA
Genome Projectprotein complex
GO:0008180
IDA
Genome ProjectCOP9 signalosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001315CARD domain
IPR001611Leucine-rich repeat
IPR007111NACHT nucleoside triphosphatase
IPR011029Death-like domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.