Gene: ENSG00000166851 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000166851
Transcript Identifier
ENST00000300093
Gene Type
Coding gene
Location
16 : 23678933-23690063 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
polo-like kinase 1

Identifiers

Type Value
pidENSP00000300093
HGNC9077
UniprotP53350

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000070
IMP
Genome Projectmitotic sister chromatid segregation
GO:0000086
IDA
TAS
Genome ProjectG2/M transition of mitotic cell cycle
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0000281
IDA
Genome Projectmitotic cytokinesis
GO:0000910
IDA, IMP
Genome Projectcytokinesis
GO:0001578
IDA
Genome Projectmicrotubule bundle formation
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0006996
TAS
Genome Projectorganelle organization
GO:0007049
IEA
Genome Projectcell cycle
GO:0007067
IDA, IMP
TAS, IEA
Genome Projectmitotic nuclear division
GO:0007077
TAS
Genome Projectmitotic nuclear envelope disassembly
GO:0007091
TAS
Genome Projectmetaphase/anaphase transition of mitotic cell cycle
GO:0007092
IDA
Genome Projectactivation of APC-Cdc20 complex activity
GO:0007094
IMP
Genome Projectmitotic spindle assembly checkpoint
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007346
IMP
Genome Projectregulation of mitotic cell cycle
GO:0008283
TAS
Genome Projectcell proliferation
GO:0010800
IMP
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016321
IEA
Genome Projectfemale meiosis chromosome segregation
GO:0016567
IDA
Genome Projectprotein ubiquitination
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0030071
IMP
Genome Projectregulation of mitotic metaphase/anaphase transition
GO:0031145
TAS
Genome Projectanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572
IDA
Genome ProjectG2 DNA damage checkpoint
GO:0031648
IDA
Genome Projectprotein destabilization
GO:0032436
IMP
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043393
IMP
Genome Projectregulation of protein binding
GO:0045143
IEA
Genome Projecthomologous chromosome segregation
GO:0045184
IMP
Genome Projectestablishment of protein localization
GO:0045736
IMP
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862
IDA
Genome Projectpositive regulation of proteolysis
GO:0051297
IMP
Genome Projectcentrosome organization
GO:0051301
IEA
Genome Projectcell division
GO:0051437
TAS
Genome Projectpositive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0051439
TAS
Genome Projectregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443
IMP
Genome Projectpositive regulation of ubiquitin-protein transferase activity
GO:0051726
TAS
Genome Projectregulation of cell cycle
GO:0070194
IEA
Genome Projectsynaptonemal complex disassembly
GO:0071168
IDA
Genome Projectprotein localization to chromatin
GO:1901673
IDA
Genome Projectregulation of mitotic spindle assembly

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
NAS, IEA
Genome Projectprotein kinase activity
GO:0004674
EXP, IDA, IMP
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008017
IDA
Genome Projectmicrotubule binding
GO:0010997
IPI
Genome Projectanaphase-promoting complex binding
GO:0016301
TAS, IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IPI
Genome Projectprotein kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000775
IEA
Genome Projectchromosome, centromeric region
GO:0000776
IDA
IEA
Genome Projectkinetochore
GO:0000777
IEA
Genome Projectcondensed chromosome kinetochore
GO:0000780
IEA
Genome Projectcondensed nuclear chromosome, centromeric region
GO:0000785
IEA
Genome Projectchromatin
GO:0000795
IEA
Genome Projectsynaptonemal complex
GO:0000922
IDA
Genome Projectspindle pole
GO:0000942
IDA
Genome Projectcondensed nuclear chromosome outer kinetochore
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005694
IEA
Genome Projectchromosome
GO:0005730
IDA
Genome Projectnucleolus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005813
IDA
Genome Projectcentrosome
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005819
IDA
IEA
Genome Projectspindle
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0015630
IDA
Genome Projectmicrotubule cytoskeleton
GO:0030496
IDA
IEA
Genome Projectmidbody
GO:0051233
IDA
Genome Projectspindle midzone
GO:0005876
IDA
Genome Projectspindle microtubule

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000959POLO box duplicated domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.