Gene: ENSG00000166225 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000166225
Transcript Identifier
ENST00000397997
Gene Type
Coding gene
Location
12 : 69569031-69574955 : positive

Family Information

Homologous gene family
HOM03P014966
(5 genes in 4 species)
specific family

Descriptions

gene_descr
fibroblast growth factor receptor substrate 2

Identifiers

Type Value
pidENSP00000381083
HGNC16971
UniprotQ8WU20
UniprotL7RTG7

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IEA
Genome Projectactivation of MAPK activity
GO:0001702
IEA
Genome Projectgastrulation with mouth forming second
GO:0001759
IEA
Genome Projectorgan induction
GO:0002088
IEA
Genome Projectlens development in camera-type eye
GO:0003281
IEA
Genome Projectventricular septum development
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007405
IEA
Genome Projectneuroblast proliferation
GO:0008595
IEA
Genome Projectanterior/posterior axis specification, embryo
GO:0030900
IEA
Genome Projectforebrain development
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0046619
IEA
Genome Projectoptic placode formation involved in camera-type eye formation
GO:0050678
IEA
Genome Projectregulation of epithelial cell proliferation
GO:0060527
IEA
Genome Projectprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0070307
IEA
Genome Projectlens fiber cell development
GO:0070372
IEA
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0000186
TAS
Genome Projectactivation of MAPKK activity
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007185
TAS
Genome Projecttransmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007186
TAS
Genome ProjectG-protein coupled receptor signaling pathway
GO:0008286
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
IGI
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005068
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158
IEA
Genome Projectinsulin receptor binding
GO:0005104
IPI
Genome Projectfibroblast growth factor receptor binding
GO:0005168
IPI
Genome Projectneurotrophin TRKA receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019211
TAS
Genome Projectphosphatase activator activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005911
IEA
Genome Projectcell-cell junction
GO:0005768
TAS
Genome Projectendosome
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0012505
IEA
Genome Projectendomembrane system
GO:0016020
TAS, IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002404IRS-type PTB domain
IPR011993PH domain-like

No MapMan annotations defined for this gene.