Gene: ENSG00000165731 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000165731
Transcript Identifier
ENST00000355710
Gene Type
Coding gene
Location
10 : 43077259-43128269 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P040742
(3 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
ret proto-oncogene

Identifiers

Type Value
pidENSP00000347942
HGNC9967
UniprotP07949
UniprotA0A024R7T2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0001657
IEA
Genome Projectureteric bud development
GO:0001755
IEA
Genome Projectneural crest cell migration
GO:0001838
IEA
Genome Projectembryonic epithelial tube formation
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0007156
IEA
Genome Projecthomophilic cell adhesion via plasma membrane adhesion molecules
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399
IEA
Genome Projectnervous system development
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0014042
IEA
Genome Projectpositive regulation of neuron maturation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
TAS, IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030182
IEA
Genome Projectneuron differentiation
GO:0035799
IEA
Genome Projectureter maturation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042551
IEA
Genome Projectneuron maturation
GO:0045793
IEA
Genome Projectpositive regulation of cell size
GO:0045893
ISS
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048265
ISS
IEA
Genome Projectresponse to pain
GO:0048484
IEA
Genome Projectenteric nervous system development
GO:0050770
IEA
Genome Projectregulation of axonogenesis
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060384
IEA
Genome Projectinnervation
GO:0061146
ISS
IEA
Genome ProjectPeyer's patch morphogenesis
GO:0072300
ISS
IEA
Genome Projectpositive regulation of metanephric glomerulus development
GO:0006919
IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007158
IMP
Genome Projectneuron cell-cell adhesion
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007497
TAS
Genome Projectposterior midgut development
GO:0010976
IMP
Genome Projectpositive regulation of neuron projection development
GO:0030155
IDA
Genome Projectregulation of cell adhesion
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0033619
IDA
Genome Projectmembrane protein proteolysis
GO:0033630
IDA
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0071300
IMP
Genome Projectcellular response to retinoic acid
GO:0097021
ISS
Genome Projectlymphocyte migration into lymphoid organs
GO:2001241
IMP
TAS
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0005509
IDA
IEA
Genome Projectcalcium ion binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004872
TAS
Genome Projectreceptor activity
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005769
IEA
Genome Projectearly endosome
GO:0016020
IEA
Genome Projectmembrane
GO:0030424
IEA
Genome Projectaxon
GO:0030425
IEA
Genome Projectdendrite
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0045121
IEA
Genome Projectmembrane raft
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005768
IEA
Genome Projectendosome
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0010008
IDA
IEA
Genome Projectendosome membrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043235
IDA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002126Cadherin
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR015919Cadherin-like
IPR016249Tyrosine-protein kinase, Ret receptor
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.