Gene: ENSG00000165025 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000165025
Transcript Identifier
ENST00000375746
Gene Type
Coding gene
Location
9 : 90843899-90895600 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P031657
(3 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
spleen tyrosine kinase

Identifiers

Type Value
pidENSP00000364898
HGNC11491
UniprotP43405
UniprotA0A024R244

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IEA
Genome Projectactivation of MAPK activity
GO:0001820
IEA
Genome Projectserotonin secretion
GO:0001945
ISS
IEA
Genome Projectlymph vessel development
GO:0002092
IEA
Genome Projectpositive regulation of receptor internalization
GO:0002281
ISS, IBA
IEA
Genome Projectmacrophage activation involved in immune response
GO:0002283
ISS, IBA
IEA
Genome Projectneutrophil activation involved in immune response
GO:0002366
ISS
IEA
Genome Projectleukocyte activation involved in immune response
GO:0002554
ISS
IEA
Genome Projectserotonin secretion by platelet
GO:0006468
IDA
ISS
IEA
Genome Projectprotein phosphorylation
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007167
IEA
Genome Projectenzyme linked receptor protein signaling pathway
GO:0007229
ISS
NAS, IEA
Genome Projectintegrin-mediated signaling pathway
GO:0007257
IEA
Genome Projectactivation of JUN kinase activity
GO:0010543
ISS
IEA
Genome Projectregulation of platelet activation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019370
IEA
Genome Projectleukotriene biosynthetic process
GO:0032481
IEA
Genome Projectpositive regulation of type I interferon production
GO:0032928
ISS
IEA
Genome Projectregulation of superoxide anion generation
GO:0033630
ISS, IBA
IEA
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0042742
ISS
IEA
Genome Projectdefense response to bacterium
GO:0043306
IBA
IEA
Genome Projectpositive regulation of mast cell degranulation
GO:0043313
ISS
IEA
Genome Projectregulation of neutrophil degranulation
GO:0043366
IEA
Genome Projectbeta selection
GO:0045087
ISS, IBA
TAS, IEA
Genome Projectinnate immune response
GO:0045401
IEA
Genome Projectpositive regulation of interleukin-3 biosynthetic process
GO:0045425
IEA
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045588
IEA
Genome Projectpositive regulation of gamma-delta T cell differentiation
GO:0045780
ISS
IEA
Genome Projectpositive regulation of bone resorption
GO:0046638
IEA
Genome Projectpositive regulation of alpha-beta T cell differentiation
GO:0046641
IBA
IEA
Genome Projectpositive regulation of alpha-beta T cell proliferation
GO:0046777
IEA
Genome Projectprotein autophosphorylation
GO:0048514
ISS
IEA
Genome Projectblood vessel morphogenesis
GO:0050715
IEA
Genome Projectpositive regulation of cytokine secretion
GO:0050731
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050764
ISS
IEA
Genome Projectregulation of phagocytosis
GO:0050850
IEA
Genome Projectpositive regulation of calcium-mediated signaling
GO:0050853
ISS, IBA
IEA
Genome ProjectB cell receptor signaling pathway
GO:0070372
ISS
IEA
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0071226
ISS
IEA
Genome Projectcellular response to molecule of fungal origin
GO:0090237
ISS
IEA
Genome Projectregulation of arachidonic acid secretion
GO:0090330
ISS, IBA
IEA
Genome Projectregulation of platelet aggregation
GO:0001525
IEA
Genome Projectangiogenesis
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002250
ISS, IBA
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0007159
IDA
Genome Projectleukocyte cell-cell adhesion
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008283
TAS
Genome Projectcell proliferation
GO:0009887
TAS
Genome Projectorgan morphogenesis
GO:0010803
IMP
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0016032
IEA
Genome Projectviral process
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030593
IDA
Genome Projectneutrophil chemotaxis
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0042991
IMP
Genome Projecttranscription factor import into nucleus
GO:0045579
IMP
Genome Projectpositive regulation of B cell differentiation
GO:0051090
IMP
Genome Projectregulation of sequence-specific DNA binding transcription factor activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
NAS, IEA
Genome Projectprotein kinase activity
GO:0004713
EXP
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IDA
TAS, IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0004716
IEA
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0004674
IDA
Genome Projectprotein serine/threonine kinase activity
GO:0005178
IPI
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0019815
IEA
Genome ProjectB cell receptor complex
GO:0032009
ISS
IEA
Genome Projectearly phagosome
GO:0043234
IDA
IEA
Genome Projectprotein complex
GO:0005634
IDA
Genome Projectnucleus
GO:0005829
TAS, IC, IEA
Genome Projectcytosol
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0042101
IDA
Genome ProjectT cell receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR012234Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR023420Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain

No MapMan annotations defined for this gene.