Gene: ENSG00000164690 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000164690
Transcript Identifier
ENST00000297261
Gene Type
Coding gene
Location
7 : 155802900-155812122 : negative

Family Information

Homologous gene family
HOM03P007513
(11 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P067633
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
sonic hedgehog

Identifiers

Type Value
pidENSP00000297261
HGNC10848
UniprotQ15465

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001569
ISS
IEA
Genome Projectpatterning of blood vessels
GO:0001570
ISS
IEA
Genome Projectvasculogenesis
GO:0001656
ISS
IEA
Genome Projectmetanephros development
GO:0001658
ISS
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001708
ISS
IEA
Genome Projectcell fate specification
GO:0001755
ISS
IEA
Genome Projectneural crest cell migration
GO:0001822
IEA
Genome Projectkidney development
GO:0001942
IEA
Genome Projecthair follicle development
GO:0001944
IEA
Genome Projectvasculature development
GO:0001947
ISS
IEA
Genome Projectheart looping
GO:0002052
IEA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0002076
IEA
Genome Projectosteoblast development
GO:0002320
IMP
Genome Projectlymphoid progenitor cell differentiation
GO:0003140
ISS
IEA
Genome Projectdetermination of left/right asymmetry in lateral mesoderm
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006508
IEA
Genome Projectproteolysis
GO:0006897
IEA
Genome Projectendocytosis
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007154
IEA
Genome Projectcell communication
GO:0007224
IEP
ISS
IEA
Genome Projectsmoothened signaling pathway
GO:0007228
ISS
IEA
Genome Projectpositive regulation of hh target transcription factor activity
GO:0007267
ISS
IEA
Genome Projectcell-cell signaling
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IEA
Genome Projectdetermination of left/right symmetry
GO:0007389
ISS
IEA
Genome Projectpattern specification process
GO:0007398
IEA
Genome Projectectoderm development
GO:0007405
ISS
IEA
Genome Projectneuroblast proliferation
GO:0007411
ISS
IEA
Genome Projectaxon guidance
GO:0007417
ISS
IEA
Genome Projectcentral nervous system development
GO:0007418
TAS
Genome Projectventral midline development
GO:0007442
IEA
Genome Projecthindgut morphogenesis
GO:0007507
ISS
IEA
Genome Projectheart development
GO:0007596
IEA
Genome Projectblood coagulation
GO:0008209
ISS
IEA
Genome Projectandrogen metabolic process
GO:0008283
IEA
Genome Projectcell proliferation
GO:0008284
IDA
ISS
Genome Projectpositive regulation of cell proliferation
GO:0009790
ISS
Genome Projectembryo development
GO:0009880
TAS
Genome Projectembryonic pattern specification
GO:0009949
ISS
IEA
Genome Projectpolarity specification of anterior/posterior axis
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0009953
ISS
IEA
Genome Projectdorsal/ventral pattern formation
GO:0010463
IEA
Genome Projectmesenchymal cell proliferation
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010629
IEA
Genome Projectnegative regulation of gene expression
GO:0014003
IEA
Genome Projectoligodendrocyte development
GO:0014706
IEA
Genome Projectstriated muscle tissue development
GO:0014858
IEA
Genome Projectpositive regulation of skeletal muscle cell proliferation
GO:0014902
IEA
Genome Projectmyotube differentiation
GO:0016539
IEA
Genome Projectintein-mediated protein splicing
GO:0021522
IEA
Genome Projectspinal cord motor neuron differentiation
GO:0021794
IEA
Genome Projectthalamus development
GO:0021904
IEA
Genome Projectdorsal/ventral neural tube patterning
GO:0021930
ISS
IEA
Genome Projectcerebellar granule cell precursor proliferation
GO:0021938
IEA
Genome Projectsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021940
IEA
Genome Projectpositive regulation of cerebellar granule cell precursor proliferation
GO:0021978
IEA
Genome Projecttelencephalon regionalization
GO:0030010
IEA
Genome Projectestablishment of cell polarity
GO:0030162
ISS
IEA
Genome Projectregulation of proteolysis
GO:0030177
IEA
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030178
IEA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030323
IEA
Genome Projectrespiratory tube development
GO:0030324
ISS
IEA
Genome Projectlung development
GO:0030326
ISS
IEA
Genome Projectembryonic limb morphogenesis
GO:0030336
ISS
IEA
Genome Projectnegative regulation of cell migration
GO:0030539
ISS
IEA
Genome Projectmale genitalia development
GO:0030850
ISS
IEA
Genome Projectprostate gland development
GO:0030878
IEA
Genome Projectthyroid gland development
GO:0030900
ISS
IEA
Genome Projectforebrain development
GO:0030901
ISS
IEA
Genome Projectmidbrain development
GO:0030902
ISS
IEA
Genome Projecthindbrain development
GO:0031016
IEA
Genome Projectpancreas development
GO:0031069
IEA
Genome Projecthair follicle morphogenesis
GO:0032435
IEA
Genome Projectnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033077
ISS
IEA
Genome ProjectT cell differentiation in thymus
GO:0033089
ISS
IEA
Genome Projectpositive regulation of T cell differentiation in thymus
GO:0033092
ISS
IEA
Genome Projectpositive regulation of immature T cell proliferation in thymus
GO:0034244
IEA
Genome Projectnegative regulation of transcription elongation from RNA polymerase II promoter
GO:0034504
IEA
Genome Projectprotein localization to nucleus
GO:0035115
IEA
Genome Projectembryonic forelimb morphogenesis
GO:0035116
IEA
Genome Projectembryonic hindlimb morphogenesis
GO:0042127
ISS
IEA
Genome Projectregulation of cell proliferation
GO:0042130
IEA
Genome Projectnegative regulation of T cell proliferation
GO:0042177
IEA
Genome Projectnegative regulation of protein catabolic process
GO:0042307
IEA
Genome Projectpositive regulation of protein import into nucleus
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042476
IEA
Genome Projectodontogenesis
GO:0042481
ISS
IEA
Genome Projectregulation of odontogenesis
GO:0042733
ISS
IEA
Genome Projectembryonic digit morphogenesis
GO:0043010
IEA
Genome Projectcamera-type eye development
GO:0043066
ISS
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043369
IDA
Genome ProjectCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043588
IEA
Genome Projectskin development
GO:0045059
ISS
IEA
Genome Projectpositive thymic T cell selection
GO:0045060
ISS
IEA
Genome Projectnegative thymic T cell selection
GO:0045109
IEA
Genome Projectintermediate filament organization
GO:0045165
IEA
Genome Projectcell fate commitment
GO:0045445
IEA
Genome Projectmyoblast differentiation
GO:0045596
ISS
IEA
Genome Projectnegative regulation of cell differentiation
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045880
IDA
ISS
Genome Projectpositive regulation of smoothened signaling pathway
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046638
ISS
IEA
Genome Projectpositive regulation of alpha-beta T cell differentiation
GO:0046639
IEA
Genome Projectnegative regulation of alpha-beta T cell differentiation
GO:0048468
ISS
IEA
Genome Projectcell development
GO:0048538
ISS
IEA
Genome Projectthymus development
GO:0048546
IEA
Genome Projectdigestive tract morphogenesis
GO:0048557
IEA
Genome Projectembryonic digestive tract morphogenesis
GO:0048568
IEA
Genome Projectembryonic organ development
GO:0048589
IEA
Genome Projectdevelopmental growth
GO:0048598
IEA
Genome Projectembryonic morphogenesis
GO:0048617
IEA
Genome Projectembryonic foregut morphogenesis
GO:0048643
IEA
Genome Projectpositive regulation of skeletal muscle tissue development
GO:0048645
IEA
Genome Projectorgan formation
GO:0048646
IEA
Genome Projectanatomical structure formation involved in morphogenesis
GO:0048663
ISS
IEA
Genome Projectneuron fate commitment
GO:0048706
IEA
Genome Projectembryonic skeletal system development
GO:0048709
IEA
Genome Projectoligodendrocyte differentiation
GO:0048714
IEA
Genome Projectpositive regulation of oligodendrocyte differentiation
GO:0048754
ISS
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048839
IEA
Genome Projectinner ear development
GO:0048856
IEA
Genome Projectanatomical structure development
GO:0048859
IEA
Genome Projectformation of anatomical boundary
GO:0048864
ISS
IEA
Genome Projectstem cell development
GO:0051146
IEA
Genome Projectstriated muscle cell differentiation
GO:0051155
IEA
Genome Projectpositive regulation of striated muscle cell differentiation
GO:0051781
IDA
Genome Projectpositive regulation of cell division
GO:0060020
IEA
Genome ProjectBergmann glial cell differentiation
GO:0060021
IEA
Genome Projectpalate development
GO:0060070
IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060173
IEA
Genome Projectlimb development
GO:0060174
IEA
Genome Projectlimb bud formation
GO:0060425
IEA
Genome Projectlung morphogenesis
GO:0060428
IEA
Genome Projectlung epithelium development
GO:0060438
IEA
Genome Projecttrachea development
GO:0060439
IEA
Genome Projecttrachea morphogenesis
GO:0060441
IEA
Genome Projectepithelial tube branching involved in lung morphogenesis
GO:0060442
IEA
Genome Projectbranching involved in prostate gland morphogenesis
GO:0060445
IEA
Genome Projectbranching involved in salivary gland morphogenesis
GO:0060447
IEA
Genome Projectbud outgrowth involved in lung branching
GO:0060458
IEA
Genome Projectright lung development
GO:0060459
IEA
Genome Projectleft lung development
GO:0060463
IEA
Genome Projectlung lobe morphogenesis
GO:0060484
IEA
Genome Projectlung-associated mesenchyme development
GO:0060516
IEA
Genome Projectprimary prostatic bud elongation
GO:0060523
IEA
Genome Projectprostate epithelial cord elongation
GO:0060662
IEA
Genome Projectsalivary gland cavitation
GO:0060664
IEA
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0060684
IEA
Genome Projectepithelial-mesenchymal cell signaling
GO:0060685
IEA
Genome Projectregulation of prostatic bud formation
GO:0060738
IDA
Genome Projectepithelial-mesenchymal signaling involved in prostate gland development
GO:0060768
IEA
Genome Projectregulation of epithelial cell proliferation involved in prostate gland development
GO:0060769
IEA
Genome Projectpositive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060782
IEA
Genome Projectregulation of mesenchymal cell proliferation involved in prostate gland development
GO:0060783
IEA
Genome Projectmesenchymal smoothened signaling pathway involved in prostate gland development
GO:0060840
IEA
Genome Projectartery development
GO:0060916
IEA
Genome Projectmesenchymal cell proliferation involved in lung development
GO:0061053
ISS
IEA
Genome Projectsomite development
GO:0061189
IDA
Genome Projectpositive regulation of sclerotome development
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0072001
IEP
Genome Projectrenal system development
GO:0072136
ISS
IEA
Genome Projectmetanephric mesenchymal cell proliferation involved in metanephros development
GO:0080125
IEA
Genome Projectmulticellular structure septum development
GO:0090090
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090370
ISS
IEA
Genome Projectnegative regulation of cholesterol efflux
GO:0097190
ISS
IEA
Genome Projectapoptotic signaling pathway
GO:1900175
NAS
Genome Projectregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900180
IDA
Genome Projectregulation of protein localization to nucleus
GO:2000062
ISS
IEA
Genome Projectnegative regulation of ureter smooth muscle cell differentiation
GO:2000063
ISS
IEA
Genome Projectpositive regulation of ureter smooth muscle cell differentiation
GO:2000357
ISS
IEA
Genome Projectnegative regulation of kidney smooth muscle cell differentiation
GO:2000358
ISS
IEA
Genome Projectpositive regulation of kidney smooth muscle cell differentiation
GO:2000729
ISS
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001054
IEA
Genome Projectnegative regulation of mesenchymal cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001948
IEA
Genome Projectglycoprotein binding
GO:0005113
IDA
Genome Projectpatched binding
GO:0005509
IDA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005539
IEA
Genome Projectglycosaminoglycan binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0016015
NAS
Genome Projectmorphogen activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0043237
ISS
IEA
Genome Projectlaminin-1 binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
ISS
IEA
Genome Projectextracellular space
GO:0005634
IEA
Genome Projectnucleus
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0009986
ISS
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0045121
ISS
IEA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000320Hedgehog, N-terminal signalling domain
IPR001657Hedgehog protein
IPR001767Hedgehog protein, Hint domain
IPR003586Hint domain C-terminal
IPR003587Hint domain N-terminal
IPR006141Intein N-terminal splicing region
IPR009045Hedgehog signalling/DD-peptidase zinc-binding domain
IPR028992Hedgehog/Intein (Hint) domain

No MapMan annotations defined for this gene.