Gene: ENSG00000164305 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000164305
Transcript Identifier
ENST00000523916
Gene Type
Coding gene
Location
4 : 184629272-184638453 : negative

Family Information

Homologous gene family
HOM03P003300
(30 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P075426
(2 genes in 2 species)
specific family

Descriptions

gene_descr
caspase 3, apoptosis-related cysteine peptidase

Identifiers

Type Value
pidENSP00000428929
HGNC1504
UniprotP42574

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001782
IEA
Genome ProjectB cell homeostasis
GO:0006309
TAS
Genome Projectapoptotic DNA fragmentation
GO:0006508
IDA
IEA
Genome Projectproteolysis
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006921
TAS
Genome Projectcellular component disassembly involved in execution phase of apoptosis
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007507
IEA
Genome Projectheart development
GO:0007605
IEA
Genome Projectsensory perception of sound
GO:0007611
IEA
Genome Projectlearning or memory
GO:0008635
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411
IEA
Genome Projectresponse to UV
GO:0009611
IEA
Genome Projectresponse to wounding
GO:0009749
IEA
Genome Projectresponse to glucose
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010038
IEA
Genome Projectresponse to metal ion
GO:0010165
IEA
Genome Projectresponse to X-ray
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016485
IEA
Genome Projectprotein processing
GO:0021766
IEA
Genome Projecthippocampus development
GO:0022617
TAS
Genome Projectextracellular matrix disassembly
GO:0030182
IBA
IEA
Genome Projectneuron differentiation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030216
IBA
IEA
Genome Projectkeratinocyte differentiation
GO:0030218
IDA
TAS
Genome Projecterythrocyte differentiation
GO:0030220
TAS
Genome Projectplatelet formation
GO:0030889
IEA
Genome Projectnegative regulation of B cell proliferation
GO:0032025
IEA
Genome Projectresponse to cobalt ion
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0034349
IEA
Genome Projectglial cell apoptotic process
GO:0034612
TAS
Genome Projectresponse to tumor necrosis factor
GO:0035094
IEA
Genome Projectresponse to nicotine
GO:0035329
TAS
Genome Projecthippo signaling
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0042060
IEA
Genome Projectwound healing
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0043029
IEA
Genome ProjectT cell homeostasis
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IGI
Genome Projectnegative regulation of apoptotic process
GO:0043085
IEA
Genome Projectpositive regulation of catalytic activity
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043281
TAS
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0045165
IEA
Genome Projectcell fate commitment
GO:0045736
IEA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786
IEA
Genome Projectnegative regulation of cell cycle
GO:0046007
IEA
Genome Projectnegative regulation of activated T cell proliferation
GO:0046677
IEA
Genome Projectresponse to antibiotic
GO:0048011
IDA
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0071310
IEA
Genome Projectcellular response to organic substance
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:0097191
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097192
TAS
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:0097194
IDA, IMP
Genome Projectexecution phase of apoptosis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IEA
Genome Projectprotease binding
GO:0004190
EXP
Genome Projectaspartic-type endopeptidase activity
GO:0004197
IDA
TAS, IEA
Genome Projectcysteine-type endopeptidase activity
GO:0004861
IEA
Genome Projectcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005123
IEA
Genome Projectdeath receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IDA
IEA
Genome Projectpeptidase activity
GO:0008234
IEA
Genome Projectcysteine-type peptidase activity
GO:0016005
IEA
Genome Projectphospholipase A2 activator activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0097153
IDA, IMP
Genome Projectcysteine-type endopeptidase activity involved in apoptotic process
GO:0097200
IMP
Genome Projectcysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IBA
IEA
Genome Projectcytoplasm
GO:0005829
IDA
TAS, IEA
Genome Projectcytosol
GO:0005886
TAS
Genome Projectplasma membrane
GO:0031264
IEA
Genome Projectdeath-inducing signaling complex
GO:0045121
IEA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001309Peptidase C14, ICE, catalytic subunit p20
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011600Peptidase C14, caspase domain
IPR015470Caspase-3
IPR015917Peptidase C14A, caspase precursor p45, core
IPR016129Peptidase C14, ICE, catalytic subunit p20, active site
IPR029030Caspase-like domain

No MapMan annotations defined for this gene.