Gene: ENSG00000162733 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000162733
Transcript Identifier
ENST00000367921
Gene Type
Coding gene
Location
1 : 162719064-162780246 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P008919
(9 genes in 4 species)
specific family

Descriptions

gene_descr
discoidin domain receptor tyrosine kinase 2

Identifiers

Type Value
pidENSP00000356898
HGNC2731
UniprotQ16832
UniprotA0A024R906

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003416
ISS
IEA
Genome Projectendochondral bone growth
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010763
ISS
TAS, IEA
Genome Projectpositive regulation of fibroblast migration
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030199
ISS
IEA
Genome Projectcollagen fibril organization
GO:0031214
ISS
IEA
Genome Projectbiomineral tissue development
GO:0035988
ISS
TAS, IEA
Genome Projectchondrocyte proliferation
GO:0038063
IDA
IEA
Genome Projectcollagen-activated tyrosine kinase receptor signaling pathway
GO:0048146
ISS
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0090091
ISS
IEA
Genome Projectpositive regulation of extracellular matrix disassembly
GO:0001503
IEA
Genome Projectossification
GO:0007155
TAS
Genome Projectcell adhesion
GO:0007165
TAS
Genome Projectsignal transduction
GO:0010715
TAS
Genome Projectregulation of extracellular matrix disassembly
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030500
IMP
Genome Projectregulation of bone mineralization
GO:0045669
IMP
Genome Projectpositive regulation of osteoblast differentiation
GO:0045860
IMP
Genome Projectpositive regulation of protein kinase activity
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IDA
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005518
IDA
IEA
Genome Projectcollagen binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0038062
IDA
IEA
Genome Projectprotein tyrosine kinase collagen receptor activity
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005887
TAS, IEA
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000421Coagulation factor 5/8 C-terminal domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002011Tyrosine-protein kinase, receptor class II, conserved site
IPR008266Tyrosine-protein kinase, active site
IPR008979Galactose-binding domain-like
IPR011009Protein kinase-like domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR029553Discoidin domain-containing receptor

No MapMan annotations defined for this gene.