Gene: ENSG00000162434 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000162434
Transcript Identifier
ENST00000342505
Gene Type
Coding gene
Location
1 : 64834562-64886264 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P011898
(7 genes in 4 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
Janus kinase 1

Identifiers

Type Value
pidENSP00000343204
HGNC6190
UniprotP23458

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0007167
IEA
Genome Projectenzyme linked receptor protein signaling pathway
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019221
TAS, IEA
Genome Projectcytokine-mediated signaling pathway
GO:0030154
IBA
Genome Projectcell differentiation
GO:0035556
TAS, IEA
Genome Projectintracellular signal transduction
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0038110
IDA
Genome Projectinterleukin-2-mediated signaling pathway
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0045087
IBA
Genome Projectinnate immune response
GO:0046677
IDA
Genome Projectresponse to antibiotic
GO:0046777
IEA
Genome Projectprotein autophosphorylation
GO:0060333
TAS
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060334
TAS
Genome Projectregulation of interferon-gamma-mediated signaling pathway
GO:0060337
TAS
Genome Projecttype I interferon signaling pathway
GO:0060338
TAS
Genome Projectregulation of type I interferon-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
EXP
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005131
ISS, IBA
IEA
Genome Projectgrowth hormone receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031730
IEA
Genome ProjectCCR5 chemokine receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0012505
IEA
Genome Projectendomembrane system
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000299FERM domain
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR017441Protein kinase, ATP binding site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR020776Tyrosine-protein kinase, non-receptor Jak1

No MapMan annotations defined for this gene.