Gene: ENSG00000162337 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000162337
Transcript Identifier
ENST00000294304
Gene Type
Coding gene
Location
11 : 68312715-68449070 : positive

Family Information

Homologous gene family
HOM03P001101
(58 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P005166
(16 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
low density lipoprotein receptor-related protein 5

Identifiers

Type Value
pidENSP00000294304
HGNC6697
UniprotO75197

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001702
IEA
Genome Projectgastrulation with mouth forming second
GO:0001944
IEA
Genome Projectvasculature development
GO:0002053
IMP
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0002076
IBA
IEA
Genome Projectosteoblast development
GO:0006007
IMP
Genome Projectglucose catabolic process
GO:0006897
IEA
Genome Projectendocytosis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008203
IEA
Genome Projectcholesterol metabolic process
GO:0008217
IMP
Genome Projectregulation of blood pressure
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0016055
IDA
IEA
Genome ProjectWnt signaling pathway
GO:0033690
IEA
Genome Projectpositive regulation of osteoblast proliferation
GO:0035019
IEA
Genome Projectsomatic stem cell population maintenance
GO:0035108
IEA
Genome Projectlimb morphogenesis
GO:0035426
IEA
Genome Projectextracellular matrix-cell signaling
GO:0042074
IEA
Genome Projectcell migration involved in gastrulation
GO:0042632
IMP
Genome Projectcholesterol homeostasis
GO:0042733
IEA
Genome Projectembryonic digit morphogenesis
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0044332
IDA
Genome ProjectWnt signaling pathway involved in dorsal/ventral axis specification
GO:0045600
IMP
Genome Projectpositive regulation of fat cell differentiation
GO:0045668
IMP
Genome Projectnegative regulation of osteoblast differentiation
GO:0045840
IDA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046849
IEA
Genome Projectbone remodeling
GO:0046850
IEA
Genome Projectregulation of bone remodeling
GO:0048539
IMP
Genome Projectbone marrow development
GO:0051091
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0060033
IEA
Genome Projectanatomical structure regression
GO:0060042
IMP
Genome Projectretina morphogenesis in camera-type eye
GO:0060070
IDA, IMP
Genome Projectcanonical Wnt signaling pathway
GO:0060348
IEA
Genome Projectbone development
GO:0060349
IMP
Genome Projectbone morphogenesis
GO:0060444
IEA
Genome Projectbranching involved in mammary gland duct morphogenesis
GO:0060603
IEA
Genome Projectmammary gland duct morphogenesis
GO:0060612
IMP
Genome Projectadipose tissue development
GO:0060764
IEA
Genome Projectcell-cell signaling involved in mammary gland development
GO:0060828
IMP
Genome Projectregulation of canonical Wnt signaling pathway
GO:0061178
IBA
IEA
Genome Projectregulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061299
IEA
Genome Projectretina vasculature morphogenesis in camera-type eye
GO:0061304
IMP
Genome Projectretinal blood vessel morphogenesis
GO:0071901
IMP
Genome Projectnegative regulation of protein serine/threonine kinase activity
GO:0090263
TAS
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1902262
IEA
Genome Projectapoptotic process involved in patterning of blood vessels

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0017147
IBA
IEA
Genome ProjectWnt-protein binding
GO:0042813
IBA
IEA
Genome ProjectWnt-activated receptor activity
GO:0019534
IMP
Genome Projecttoxin transporter activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043235
IDA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000033LDLR class B repeat
IPR000742EGF-like domain
IPR002172Low-density lipoprotein (LDL) receptor class A repeat
IPR011042Six-bladed beta-propeller, TolB-like
IPR017049Low density lipoprotein receptor-related protein 5/6
IPR023415Low-density lipoprotein (LDL) receptor class A, conserved site

No MapMan annotations defined for this gene.