Gene: ENSG00000160712 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000160712
Transcript Identifier
ENST00000368485
Gene Type
Coding gene
Location
1 : 154405630-154465380 : positive

Family Information

Homologous gene family
HOM03P007870
(11 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P071255
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 6 receptor

Identifiers

Type Value
pidENSP00000357470
HGNC6019
UniprotP08887
UniprotA0N0L5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008284
IDA, IMP
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0016049
IEA
Genome Projectcell growth
GO:0019221
IDA
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0042517
IMP
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0046427
IEA
Genome Projectpositive regulation of JAK-STAT cascade
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051591
IEA
Genome Projectresponse to cAMP
GO:0070102
IMP
IEA
Genome Projectinterleukin-6-mediated signaling pathway
GO:0002384
TAS
Genome Projecthepatic immune response
GO:0002446
TAS
Genome Projectneutrophil mediated immunity
GO:0002548
IC
Genome Projectmonocyte chemotaxis
GO:0002690
TAS
Genome Projectpositive regulation of leukocyte chemotaxis
GO:0006953
TAS
Genome Projectacute-phase response
GO:0010536
IDA
Genome Projectpositive regulation of activation of Janus kinase activity
GO:0031018
IMP
IC
Genome Projectendocrine pancreas development
GO:0032717
NAS
Genome Projectnegative regulation of interleukin-8 production
GO:0032722
IDA
Genome Projectpositive regulation of chemokine production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032966
IDA
Genome Projectnegative regulation of collagen biosynthetic process
GO:0034097
IDA
Genome Projectresponse to cytokine
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0045669
TAS
Genome Projectpositive regulation of osteoblast differentiation
GO:0048661
IDA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050829
TAS
Genome Projectdefense response to Gram-negative bacterium
GO:0050830
NAS
Genome Projectdefense response to Gram-positive bacterium
GO:0070120
IMP
Genome Projectciliary neurotrophic factor-mediated signaling pathway
GO:0097191
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004896
IEA
Genome Projectcytokine receptor activity
GO:0004915
IDA
IEA
Genome Projectinterleukin-6 receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019981
IPI
Genome Projectinterleukin-6 binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0070119
IPI
Genome Projectciliary neurotrophic factor binding
GO:0004897
IMP
Genome Projectciliary neurotrophic factor receptor activity
GO:0005138
IPI
Genome Projectinterleukin-6 receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0032809
IEA
Genome Projectneuronal cell body membrane
GO:0005576
IDA
TAS, IEA
Genome Projectextracellular region
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005896
IDA
Genome Projectinterleukin-6 receptor complex
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
IEA
Genome Projectbasolateral plasma membrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0070110
IDA
Genome Projectciliary neurotrophic factor receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003530Long hematopoietin receptor, soluble alpha chain, conserved site
IPR003598Immunoglobulin subtype 2
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR015321Type I cytokine receptor, cytokine-binding domain

No MapMan annotations defined for this gene.