Gene: ENSG00000158828 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000158828
Transcript Identifier
ENST00000321556
Gene Type
Coding gene
Location
1 : 20633549-20650691 : positive

Family Information

Homologous gene family
HOM03P025570
(3 genes in 3 species)
specific family

Descriptions

gene_descr
PTEN induced putative kinase 1

Identifiers

Type Value
pidENSP00000364204
HGNC14581
UniprotQ9BXM7

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000422
IMP
Genome Projectmitophagy
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0002082
IDA
Genome Projectregulation of oxidative phosphorylation
GO:0006468
IDA, IMP
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006511
TAS
Genome Projectubiquitin-dependent protein catabolic process
GO:0006914
IEA
Genome Projectautophagy
GO:0006950
IDA
Genome Projectresponse to stress
GO:0006979
IGI
Genome Projectresponse to oxidative stress
GO:0007005
IMP
Genome Projectmitochondrion organization
GO:0010310
IEA
Genome Projectregulation of hydrogen peroxide metabolic process
GO:0010629
ISS
IEA
Genome Projectnegative regulation of gene expression
GO:0010821
IMP
Genome Projectregulation of mitochondrion organization
GO:0010952
TAS
Genome Projectpositive regulation of peptidase activity
GO:0016239
IMP
Genome Projectpositive regulation of macroautophagy
GO:0016242
IMP
Genome Projectnegative regulation of macroautophagy
GO:0016310
NAS, IEA
Genome Projectphosphorylation
GO:0016567
IMP
Genome Projectprotein ubiquitination
GO:0018105
IDA
TAS
Genome Projectpeptidyl-serine phosphorylation
GO:0022904
IEA
Genome Projectrespiratory electron transport chain
GO:0031396
IDA, IMP
Genome Projectregulation of protein ubiquitination
GO:0032148
IC
Genome Projectactivation of protein kinase B activity
GO:0032226
IEA
Genome Projectpositive regulation of synaptic transmission, dopaminergic
GO:0033138
IDA, IMP
TAS
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033603
IEA
Genome Projectpositive regulation of dopamine secretion
GO:0033605
IEA
Genome Projectpositive regulation of catecholamine secretion
GO:0034599
IMP
IEA
Genome Projectcellular response to oxidative stress
GO:0035307
IEA
Genome Projectpositive regulation of protein dephosphorylation
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0036289
IMP
TAS
Genome Projectpeptidyl-serine autophosphorylation
GO:0038203
IC
Genome ProjectTORC2 signaling
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254
IDA
Genome Projectregulation of protein complex assembly
GO:0043523
IEA
Genome Projectregulation of neuron apoptotic process
GO:0043524
IMP
Genome Projectnegative regulation of neuron apoptotic process
GO:0045727
IEA
Genome Projectpositive regulation of translation
GO:0046329
TAS
Genome Projectnegative regulation of JNK cascade
GO:0050821
IMP
Genome Projectprotein stabilization
GO:0051091
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051443
TAS
Genome Projectpositive regulation of ubiquitin-protein transferase activity
GO:0051881
IMP, IGI
Genome Projectregulation of mitochondrial membrane potential
GO:0051897
IC
Genome Projectpositive regulation of protein kinase B signaling
GO:0061136
NAS
Genome Projectregulation of proteasomal protein catabolic process
GO:0071456
IMP
Genome Projectcellular response to hypoxia
GO:0090141
IBA
Genome Projectpositive regulation of mitochondrial fission
GO:0090200
IMP
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090258
IMP
Genome Projectnegative regulation of mitochondrial fission
GO:0097237
TAS, IEA
Genome Projectcellular response to toxic substance
GO:0098779
IMP
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1902176
IDA
Genome Projectnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902803
TAS
Genome Projectregulation of synaptic vesicle transport
GO:1902902
IMP
Genome Projectnegative regulation of autophagosome assembly
GO:1902958
TAS
Genome Projectpositive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903146
TAS
Genome Projectregulation of mitophagy
GO:1903147
IMP
Genome Projectnegative regulation of mitophagy
GO:1903202
IDA
Genome Projectnegative regulation of oxidative stress-induced cell death
GO:1903204
TAS
Genome Projectnegative regulation of oxidative stress-induced neuron death
GO:1903214
IDA, IMP, IGI
Genome Projectregulation of protein targeting to mitochondrion
GO:1903298
IEA
Genome Projectnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903384
IDA, IMP
Genome Projectnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903852
IMP
Genome Projectpositive regulation of cristae formation
GO:1903955
IMP
Genome Projectpositive regulation of protein targeting to mitochondrion
GO:2000377
IMP, IGI
Genome Projectregulation of reactive oxygen species metabolic process
GO:2000378
IMP
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:2001171
TAS
Genome Projectpositive regulation of ATP biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
IDA
Genome Projectmagnesium ion binding
GO:0002020
IPI
TAS
Genome Projectprotease binding
GO:0004672
IMP
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0010857
IDA
Genome Projectcalcium-dependent protein kinase activity
GO:0016301
IDA
NAS, IEA
Genome Projectkinase activity
GO:0016504
TAS
Genome Projectpeptidase activator activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0043422
IDA
Genome Projectprotein kinase B binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0055131
IPI
Genome ProjectC3HC4-type RING finger domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000785
IDA
Genome Projectchromatin
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA, IGI
IEA
Genome Projectmitochondrion
GO:0005741
IDA, IMP
IEA
Genome Projectmitochondrial outer membrane
GO:0005743
IDA
Genome Projectmitochondrial inner membrane
GO:0005758
IDA
Genome Projectmitochondrial intermembrane space
GO:0005829
IDA
IEA
Genome Projectcytosol
GO:0005856
IDA
Genome Projectcytoskeleton
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030424
IDA
Genome Projectaxon
GO:0031307
IDA
Genome Projectintegral component of mitochondrial outer membrane
GO:0044297
IDA
Genome Projectcell body
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0097413
TAS
Genome ProjectLewy body
GO:0097449
IDA
Genome Projectastrocyte projection
GO:0005742
IMP
Genome Projectmitochondrial outer membrane translocase complex
GO:0031932
IPI
Genome ProjectTORC2 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain

No MapMan annotations defined for this gene.