Gene: ENSG00000157404 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000157404
Transcript Identifier
ENST00000288135
Gene Type
Coding gene
Location
4 : 54658015-54738557 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P024299
(4 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Identifiers

Type Value
pidENSP00000288135
HGNC6342
UniprotP10721
UniprotA0A024RDA0

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001541
ISS
IEA
Genome Projectovarian follicle development
GO:0002318
IEA
Genome Projectmyeloid progenitor cell differentiation
GO:0002320
IEA
Genome Projectlymphoid progenitor cell differentiation
GO:0002327
ISS
IEA
Genome Projectimmature B cell differentiation
GO:0002371
ISS
IEA
Genome Projectdendritic cell cytokine production
GO:0002573
IEA
Genome Projectmyeloid leukocyte differentiation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006687
IEA
Genome Projectglycosphingolipid metabolic process
GO:0006954
ISS
IEA
Genome Projectinflammatory response
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007283
ISS
TAS, IEA
Genome Projectspermatogenesis
GO:0007286
IEA
Genome Projectspermatid development
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008354
IEA
Genome Projectgerm cell migration
GO:0008360
ISS
IEA
Genome Projectregulation of cell shape
GO:0008542
IEA
Genome Projectvisual learning
GO:0009314
IEA
Genome Projectresponse to radiation
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0023014
TAS, IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030032
ISS
IEA
Genome Projectlamellipodium assembly
GO:0030097
TAS, IEA
Genome Projecthemopoiesis
GO:0030217
ISS
IEA
Genome ProjectT cell differentiation
GO:0030218
ISS
IEA
Genome Projecterythrocyte differentiation
GO:0030318
ISS
TAS, IEA
Genome Projectmelanocyte differentiation
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0031274
IEA
Genome Projectpositive regulation of pseudopodium assembly
GO:0035019
IEA
Genome Projectsomatic stem cell population maintenance
GO:0035162
ISS
IEA
Genome Projectembryonic hemopoiesis
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0035855
ISS
IEA
Genome Projectmegakaryocyte development
GO:0038093
IDA
IEA
Genome ProjectFc receptor signaling pathway
GO:0038109
IDA
IEA
Genome ProjectKit signaling pathway
GO:0038162
ISS
IEA
Genome Projecterythropoietin-mediated signaling pathway
GO:0043069
IEA
Genome Projectnegative regulation of programmed cell death
GO:0043406
IEA
Genome Projectpositive regulation of MAP kinase activity
GO:0043473
ISS
IEA
Genome Projectpigmentation
GO:0045747
IEA
Genome Projectpositive regulation of Notch signaling pathway
GO:0046777
IDA
IEA
Genome Projectprotein autophosphorylation
GO:0048066
IEA
Genome Projectdevelopmental pigmentation
GO:0048070
IEA
Genome Projectregulation of developmental pigmentation
GO:0048103
IEA
Genome Projectsomatic stem cell division
GO:0048170
IEA
Genome Projectpositive regulation of long-term neuronal synaptic plasticity
GO:0048565
ISS
IEA
Genome Projectdigestive tract development
GO:0048863
ISS
IEA
Genome Projectstem cell differentiation
GO:0050673
IEA
Genome Projectepithelial cell proliferation
GO:0050910
ISS
IEA
Genome Projectdetection of mechanical stimulus involved in sensory perception of sound
GO:0060374
ISS
TAS, IEA
Genome Projectmast cell differentiation
GO:0097067
IEA
Genome Projectcellular response to thyroid hormone stimulus
GO:0097324
ISS
IEA
Genome Projectmelanocyte migration
GO:0097326
ISS
IEA
Genome Projectmelanocyte adhesion
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0002551
IDA
Genome Projectmast cell chemotaxis
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0008584
IEP
Genome Projectmale gonad development
GO:0010863
TAS
Genome Projectpositive regulation of phospholipase C activity
GO:0014068
TAS
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0019221
IDA
Genome Projectcytokine-mediated signaling pathway
GO:0019827
TAS
Genome Projectstem cell population maintenance
GO:0031532
IDA
Genome Projectactin cytoskeleton reorganization
GO:0032762
IDA
Genome Projectmast cell cytokine production
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0042127
TAS
Genome Projectregulation of cell proliferation
GO:0042511
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043303
IMP
Genome Projectmast cell degranulation
GO:0043410
IMP
Genome Projectpositive regulation of MAPK cascade
GO:0043552
TAS
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045087
TAS
Genome Projectinnate immune response
GO:0046427
IMP
Genome Projectpositive regulation of JAK-STAT cascade
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0060326
IDA
Genome Projectcell chemotaxis
GO:0070662
TAS
Genome Projectmast cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0002020
IEA
Genome Projectprotease binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IDA
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004716
TAS, IEA
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0005020
IEA
Genome Projectstem cell factor receptor activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019955
IDA
IEA
Genome Projectcytokine binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005911
IEA
Genome Projectcell-cell junction
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0009898
IEA
Genome Projectcytoplasmic side of plasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005615
IDA
Genome Projectextracellular space
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0042629
IMP
Genome Projectmast cell granule

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001824Tyrosine-protein kinase, receptor class III, conserved site
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR016243Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR027263Mast/stem cell growth factor receptor

No MapMan annotations defined for this gene.